The next seminar of the CoE for Genomics and Translational Medicine will be held on November 10, 2017, at 14:15, in room 105 (Omicum)
Prof. Tõnis Timmusk from the Tallinn Technical University will give a talk: “The intellectual disability and schizophrenia associated transcription factor TCF4 is regulated by neuronal activity”
Transcription factor TCF4 (alias ITF2, SEF2 or E2-2) is a broadly expressed basic helix-loop-helix protein that binds to E-box DNA sequences (CANNTG) as a homo- or heterodimer. While involved in the development and functioning of many different cell types, recent studies point to important roles for TCF4 in the nervous system. Specifically, human TCF4 gene is implicated in susceptibility to schizophrenia and mutations in one of the TCF4 alleles cause Pitt-Hopkins syndrome (PTHS), a rare developmental disorder characterized by severe motor and mental retardation. Our novel data showing that synaptic activation of nerve cells, that is the basis of brain function, regulates TCF4 transcriptional activity and function in neurons, will be presented.
The seminar will be held in English.
The Centre of Excellence for Genomics and Translational Medicine is funded by EU European Regional Development Fund ((project No. 2014-2020.4.01.15-0012).
For further information, please contact:
Project Manager / Estonian Genome Center, University of Tartu
Riia 23b Tartu 51010 Estonia
Tel: +372 7374 055 / Mob: +372 56621301
email: maris.vali-taht [ät] ut.ee / www.biobank.ee