2012 (1)

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways (PDF)
Stolk L, Perry JR, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, Esko T, Franceschini N, Gudbjartsson DF, Hottenga JJ, Kraft P, McArdle PF, Porcu E, Shin SY, Smith AV, van Wingerden S, Zhai G, Zhuang WV, Albrecht E, Alizadeh BZ, Aspelund T, Bandinelli S, Lauc LB, Beckmann JS, Boban M, Boerwinkle E, Broekmans FJ, Burri A, Campbell H, Chanock SJ, Chen C, Cornelis MC, Corre T, Coviello AD, d''Adamo P, Davies G, de Faire U, de Geus EJ, Deary IJ, Dedoussis GV, Deloukas P, Ebrahim S, Eiriksdottir G, Emilsson V, Eriksson JG, Fauser BC, Ferreli L, Ferrucci L, Fischer K, Folsom AR, Garcia ME, Gasparini P, Gieger C, Glazer N, Grobbee DE, Hall P, Haller T, Hankinson SE, Hass M, Hayward C, Heath AC, Hofman A, Ingelsson E, Janssens AC, Johnson AD, Karasik D, Kardia SL, Keyzer J, Kiel DP, Kolcic I, Kutalik Z, Lahti J, Lai S, Laisk T, Laven JS, Lawlor DA, Liu J, Lopez LM, Louwers YV, Magnusson PK, Marongiu M, Martin NG, Klaric IM, Masciullo C, McKnight B, Medland SE, Melzer D, Mooser V, Navarro P, Newman AB, Nyholt DR, Onland-Moret NC, Palotie A, Paré G, Parker AN, Pedersen NL, Peeters PH, Pistis G, Plump AS, Polasek O, Pop VJ, Psaty BM, Räikkönen K, Rehnberg E, Rotter JI, Rudan I, Sala C, Salumets A, Scuteri A, Singleton A, Smith JA, Snieder H, Soranzo N, Stacey SN, Starr JM, Stathopoulou MG, Stirrups K, Stolk RP, Styrkarsdottir U, Sun YV, Tenesa A, Thorand B, Toniolo D, Tryggvadottir L, Tsui K, Ulivi S, van Dam RM, van der Schouw YT, van Gils CH, van Nierop P, Vink JM, Visscher PM, Voorhuis M, Waeber G, Wallaschofski H, Wichmann HE, Widen E, Wijnands-van Gent CJ, Willemsen G, Wilson JF, Wolffenbuttel BH, Wright AF, Yerges-Armstrong LM, Zemunik T, Zgaga L, Zillikens MC, Zygmunt M, Study TL, Arnold AM, Boomsma DI, Buring JE, Crisponi L, Demerath EW, Gudnason V, Harris TB, Hu FB, Hunter DJ, Launer LJ, Metspalu A, Montgomery GW, Oostra BA, Ridker PM, Sanna S, Schlessinger D, Spector TD, Stefansson K, Streeten EA, Thorsteinsdottir U, Uda M, Uitterlinden AG, van Duijn CM, Völzke H, Murray A, Murabito JM, Visser JA, Lunetta KL.
Published in: Nat Genet. 2012 Jan 22;44(3):260-8
DOI: 10.1038/ng.1051

2011 (14)

The role of a Bioresource Research Impact Factor as an incentive to share human bioresources.
Cambon-Thomsen, A., Thorisson, G. a, Mabile, L., Andrieu, S., Bertier, G., Boeckhout, M., Carpenter, J., Dagher, G., Dalgleish, R., Deschênes, M., di Donato, J.H., Filocamo, M., Goldberg, M., Hewitt, R., Hofman, P., Kauffmann, F., Leitsalu, L., Lomba, I., Melegh, B., Metspalu, A., Miranda, L., Napolitani, F., Oestergaard, M.Z., Parodi, B., Pasterk, M., Reiche, A., Rial-Sebbag, E., Rivalle, G., Rochaix, P., Susbielle, G., Tarasova, L., Thomsen, M., Zawati, M.H. & Zins, M.
Published in: Nature genetics 43, 503-4

A Variant in MCF2L Is Associated with Osteoarthritis.
Day-Williams, A.G., Southam, L., Panoutsopoulou, K., Rayner, N.W., Esko, T., Estrada, K., Helgadottir, H.T., Hofman, A., Ingvarsson, T., Jonsson, H., Keis, A., Kerkhof, H.J.M., Thorleifsson, G., Arden, N.K., Carr, A., Chapman, K., Deloukas, P., Loughlin, J., McCaskie, A., Ollier, W.E.R., Ralston, S.H., Spector, T.D., Wallis, G.A., Wilkinson, J.M., Aslam, N., Birell, F., Carluke, I., Joseph, J., Rai, A., Reed, M., Walker, K., Doherty, S.A., Jonsdottir, I., Maciewicz, R.A., Muir, K.R., Metspalu, A., Rivadeneira, F., Stefansson, K., Styrkarsdottir, U., Uitterlinden, A.G., van Meurs, J.B.J., Zhang, W., Valdes, A.M., Doherty, M. & Zeggini, E.
Published in: American journal of human genetics 89, 446-50

New gene functions in megakaryopoiesis and platelet formation.
Gieger, C., Radhakrishnan, A., Cvejic, A., Tang, W., Porcu, E., Pistis, G., Serbanovic-Canic, J., Elling, U., Goodall, A.H., Labrune, Y., Lopez, L.M., Mägi, R., Meacham, S., Okada, Y., Pirastu, N., Sorice, R., Teumer, A., Voss, K., Zhang, W., Ramirez-Solis, R., Bis, J.C., Ellinghaus, D., Gögele, M., Hottenga, J.-J., Langenberg, C., Kovacs, P., O’Reilly, P.F., Shin, S.-Y., Esko, T., Hartiala, J., Kanoni, S., Murgia, F., Parsa, A., Stephens, J., van der Harst, P., Ellen van der Schoot, C., Allayee, H., Attwood, A., Balkau, B., Bastardot, F., Basu, S., Baumeister, S.E., Biino, G., Bomba, L., Bonnefond, A., Cambien, F., Chambers, J.C., Cucca, F., D’Adamo, P., Davies, G., de Boer, R.A., de Geus, E.J.C., Döring, A., Elliott, P., Erdmann, J., Evans, D.M., Falchi, M., Feng, W., Folsom, A.R., Frazer, I.H., Gibson, Q.D., Glazer, N.L., Hammond, C., Hartikainen, A.-L., Heckbert, S.R., Hengstenberg, C., Hersch, M., Illig, T., Loos, R.J.F., Jolley, J., Tee Khaw, K., Kühnel, B., Kyrtsonis, M.-C., Lagou, V., Lloyd-Jones, H., Lumley, T., Mangino, M., Maschio, A., Mateo Leach, I., McKnight, B., Memari, Y., Mitchell, B.D., Montgomery, G.W., Nakamura, Y., Nauck, M., Navis, G., Nöthlings, U., Nolte, I.M., Porteous, D.J., Pouta, A., Pramstaller, P.P., Pullat, J., Ring, S.M., Rotter, J.I., Ruggiero, D., Ruokonen, A., Sala, C., Samani, N.J., Sambrook, J., Schlessinger, D., Schreiber, S., Schunkert, H., Scott, J., Smith, N.L., Snieder, H., Starr, J.M., Stumvoll, M., Takahashi, A., Wilson Tang, W.H., Taylor, K., Tenesa, A., Lay Thein, S., Tönjes, A., Uda, M., Ulivi, S., van Veldhuisen, D.J., Visscher, P.M., Völker, U., Wichmann, H.-E., Wiggins, K.L., Willemsen, G., Yang, T.-P., Hua Zhao, J., Zitting, P., Bradley, J.R., Dedoussis, G.V., Gasparini, P., Hazen, S.L., Metspalu, A., Pirastu, M., Shuldiner, A.R., Joost van Pelt, L., Zwaginga, J.-J., Boomsma, D.I., Deary, I.J., Franke, A., Froguel, P., Ganesh, S.K., Jarvelin, M.-R., Martin, N.G., Meisinger, C., Psaty, B.M., Spector, T.D., Wareham, N.J., Akkerman, J.-W.N., Ciullo, M., Deloukas, P., Greinacher, A., Jupe, S., Kamatani, N., Khadake, J., Kooner, J.S., Penninger, J., Prokopenko, I., Stemple, D., Toniolo, D., Wernisch, L., Sanna, S., Hicks, A.A., Rendon, A., Ferreira, M.A., Ouwehand, W.H. & Soranzo, N.
Published in: Nature

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.
Jacquemont, S., Reymond, A., Zufferey, F., Harewood, L., Walters, R.G., Kutalik, Z., Martinet, D., Shen, Y., Valsesia, A., Beckmann, N.D., Thorleifsson, G., Belfiore, M., Bouquillon, S., Campion, D., de Leeuw, N., de Vries, B.B.A., Esko, T., Fernandez, B.A., Fernández-Aranda, F., Fernández-Real, J.M., Gratacòs, M., Guilmatre, A., Hoyer, J., Jarvelin, M.-R., Frank Kooy, R., Kurg, A., Le Caignec, C., Männik, K., Platt, O.S., Sanlaville, D., Van Haelst, M.M., Villatoro Gomez, S., Walha, F., Wu, B.-lin, Yu, Y., Aboura, A., Addor, M.-C., Alembik, Y., Antonarakis, S.E., Arveiler, B., Barth, M., Bednarek, N., Béna, F., Bergmann, S., Beri, M., Bernardini, L., Blaumeiser, B., Bonneau, D., Bottani, A., Boute, O., Brunner, H.G., Cailley, D., Callier, P., Chiesa, J., Chrast, J., Coin, L., Coutton, C., Cuisset, J.-M., Cuvellier, J.-C., David, A., de Freminville, B., Delobel, B., Delrue, M.-A., Demeer, B., Descamps, D., Didelot, G., Dieterich, K., Disciglio, V., Doco-Fenzy, M., Drunat, S., Duban-Bedu, B., Dubourg, C., El-Sayed Moustafa, J.S., Elliott, P., Faas, B.H.W., Faivre, L., Faudet, A., Fellmann, F., Ferrarini, A., Fisher, R., Flori, E., Forer, L., Gaillard, D., Gerard, M., Gieger, C., Gimelli, S., Gimelli, G., Grabe, H.J., Guichet, A., Guillin, O., Hartikainen, A.-L., Heron, D., Hippolyte, L., Holder, M., Homuth, G., Isidor, B., Jaillard, S., Jaros, Z., Jiménez-Murcia, S., Joly Helas, G., Jonveaux, P., Kaksonen, S., Keren, B., Kloss-Brandstätter, A., Knoers, N.V.A.M., Koolen, D.A., Kroisel, P.M., Kronenberg, F., Labalme, A., Landais, E., Lapi, E., Layet, V., Legallic, S., Leheup, B., Leube, B., Lewis, S., Lucas, J., MacDermot, K.D., Magnusson, P., Marshall, C., Mathieu-Dramard, M., McCarthy, M.I., Meitinger, T., Antonietta Mencarelli, M., Merla, G., Moerman, A., Mooser, V., Morice-Picard, F., Mucciolo, M., Nauck, M., Coumba Ndiaye, N., Nordgren, A., Pasquier, L., Petit, F., Pfundt, R., Plessis, G., Rajcan-Separovic, E., Paolo Ramelli, G., Rauch, A., Ravazzolo, R., Reis, A., Renieri, A., Richart, C., Ried, J.S., Rieubland, C., Roberts, W., Roetzer, K.M., Rooryck, C., Rossi, M., Saemundsen, E., Satre, V., Schurmann, C., Sigurdsson, E., Stavropoulos, D.J., Stefansson, H., Tengström, C., Thorsteinsdóttir, U., Tinahones, F.J., Touraine, R., Vallée, L., van Binsbergen, E., Van der Aa, N., Vincent-Delorme, C., Visvikis-Siest, S., Vollenweider, P., Völzke, H., Vulto-van Silfhout, A.T., Waeber, G., Wallgren-Pettersson, C., Witwicki, R.M., Zwolinksi, S., Andrieux, J., Estivill, X., Gusella, J.F., Gustafsson, O., Metspalu, A., Scherer, S.W., Stefansson, K., Blakemore, A.I.F., Beckmann, J.S. & Froguel, P.
Published in: Nature 478, 97-102

The role of COX-2 and Nrf2/ARE in anti-inflammation and antioxidative stress: Aging and anti-aging.
Luo, C., Urgard, E., Vooder, T. & Metspalu, A.
Published in: Medical hypotheses 77, 174-8

Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways.
Muiños-Gimeno, M., Espinosa-Parrilla, Y., Guidi, M., Kagerbauer, B., Sipilä, T., Maron, E., Pettai, K., Kananen, L., Navinés, R., Martín-Santos, R., Gratacòs, M., Metspalu, A., Hovatta, I. & Estivill, X.
Published in: Biological psychiatry 69, 526-33

Variation in FGF1, FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate.
Nikopensius, T., Kempa, I., Ambrozaitytė, L., Jagomägi, T., Saag, M., Matulevičienė, A., Utkus, A., Krjutškov, K., Tammekivi, V., Piekuse, L., Akota, I., Barkane, B., Krumina, A., Klovins, J., Lace, B., Kučinskas, V. & Metspalu, A.
Published in: Birth defects research. Part A, Clinical and molecular teratology 91, 218-25

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study.
Panoutsopoulou, K., Southam, L., Elliott, K.S., Wrayner, N., Zhai, G., Beazley, C., Thorleifsson, G., Arden, N.K., Carr, A., Chapman, K., Deloukas, P., Doherty, M., McCaskie, A., Ollier, W.E.R., Ralston, S.H., Spector, T.D., Valdes, A.M., Wallis, G.A., Wilkinson, J.M., Arden, E., Battley, K., Blackburn, H., Blanco, F.J., Bumpstead, S., Cupples, L.A., Day-Williams, A.G., Dixon, K., Doherty, S.A., Esko, T., Evangelou, E., Felson, D., Gomez-Reino, J.J., Gonzalez, A., Gordon, A., Gwilliam, R., Halldorsson, B.V., Hauksson, V.B., Hofman, A., Hunt, S.E., Ioannidis, J.P.A., Ingvarsson, T., Jonsdottir, I., Jonsson, H., Keen, R., Kerkhof, H.J.M., Kloppenburg, M.G., Koller, N., Lakenberg, N., Lane, N.E., Lee, A.T., Metspalu, A., Meulenbelt, I., Nevitt, M.C., O’Neill, F., Parimi, N., Potter, S.C., Rego-Perez, I., Riancho, J.A., Sherburn, K., Slagboom, P.E., Stefansson, K., Styrkarsdottir, U., Sumillera, M., Swift, D., Thorsteinsdottir, U., Tsezou, A., Uitterlinden, A.G., van Meurs, J.B.J., Watkins, B., Wheeler, M., Mitchell, S., Zhu, Y., Zmuda, J.M., Zeggini, E. & Loughlin, J.
Published in: Annals of the rheumatic diseases 70, 864-7

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.
Schumann, G., Coin, L.J., Lourdusamy, A., Charoen, P., Berger, K.H., Stacey, D., Desrivières, S., Aliev, F.A., Khan, A.A., Amin, N., Aulchenko, Y.S., Bakalkin, G., Bakker, S.J., Balkau, B., Beulens, J.W., Bilbao, A., de Boer, R.A., Beury, D., Bots, M.L., Breetvelt, E.J., Cauchi, S., Cavalcanti-Proença, C., Chambers, J.C., Clarke, T.-K., Dahmen, N., de Geus, E.J., Dick, D., Ducci, F., Easton, A., Edenberg, H.J., Esko, T., Esk, T., Fernández-Medarde, A., Foroud, T., Freimer, N.B., Girault, J.-A., Grobbee, D.E., Guarrera, S., Gudbjartsson, D.F., Hartikainen, A.-L., Heath, A.C., Hesselbrock, V., Hofman, A., Hottenga, J.-J., Isohanni, M.K., Kaprio, J., Khaw, K.-T., Kuehnel, B., Laitinen, J., Lobbens, S., Luan, J., Mangino, M., Maroteaux, M., Matullo, G., McCarthy, M.I., Mueller, C., Navis, G., Numans, M.E., Núñez, A., Nyholt, D.R., Onland-Moret, C.N., Oostra, B.A., O’Reilly, P.F., Palkovits, M., Penninx, B.W., Polidoro, S., Pouta, A., Prokopenko, I., Ricceri, F., Santos, E., Smit, J.H., Soranzo, N., Song, K., Sovio, U., Stumvoll, M., Surakk, I., Thorgeirsson, T.E., Thorsteinsdottir, U., Troakes, C., Tyrfingsson, T., Tönjes, A., Uiterwaal, C.S., Uitterlinden, A.G., van der Harst, P., van der Schouw, Y.T., Staehlin, O., Vogelzangs, N., Vollenweider, P., Waeber, G., Wareham, N.J., Waterworth, D.M., Whitfield, J.B., Wichmann, E.H., Willemsen, G., Witteman, J.C., Yuan, X., Zhai, G., Zhao, J.H., Zhang, W., Martin, N.G., Metspalu, A., Doering, A., Scott, J., Spector, T.D., Loos, R.J., Boomsma, D.I., Mooser, V., Peltonen, L., Stefansson, K., van Duijn, C.M., Vineis, P., Sommer, W.H., Kooner, J.S., Spanagel, R., Heberlein, U.A., Jarvelin, M.-R. & Elliott, P.
Published in: Proceedings of the National Academy of Sciences of the United States of America 108, 7119-24

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
Speliotes, E.K., Yerges-Armstrong, L.M., Wu, J., Hernaez, R., Kim, L.J., Palmer, C.D., Gudnason, V., Eiriksdottir, G., Garcia, M.E., Launer, L.J., Nalls, M.A., Clark, J.M., Mitchell, B.D., Shuldiner, A.R., Butler, J.L., Tomas, M., Hoffmann, U., Hwang, S.-J., Massaro, J.M., O’Donnell, C.J., Sahani, D.V., Salomaa, V., Schadt, E.E., Schwartz, S.M., Siscovick, D.S., Voight, B.F., Carr, J.J., Feitosa, M.F., Harris, T.B., Fox, C.S., Smith, A.V., Kao, W.H.L., Hirschhorn, J.N. & Borecki, I.B.
Published in: PLoS genetics 7, e1001324

Identification of miR-374a as a prognostic marker for survival in patients with early-stage nonsmall cell lung cancer.
Võsa, U., Vooder, T., Kolde, R., Fischer, K., Välk, K., Tõnisson, N., Roosipuu, R., Vilo, J., Metspalu, A. & Annilo, T.
Published in: Genes, chromosomes & cancer 50, 812-22

Investigating gene expression profile of non-small cell lung cancer.
Vooder, T. & Metspalu, A.
Published in: Cent. Eur. J. Med.

Metagenes associated with survival in NSCLC.
Urgard, E., Vooder, T., Võsa, U., Välk, K., Liu, M., Luo, C., Hoti, F., Roosipuu, R., Annilo, T., Laine, J., Frenz, C.M., Zhang, L. & Metspalu, A.
Published in: Cancer Informatics, 10, 175-183

The Estonian Biobank – the gateway for the stratified medicine.,
Metspalu, A., Leitsalu L., Milani M., Esko T., Allik A., Lilienthal K., Tammesoo M-L., Haller T., Kaasik A-T., Nelis M., Hass M., Fischer K., Krjutskov K., Leego E., Alavere H., Perola M.
Published in: Research in Estonia Present and Future, 283-301

2010 (29)

CLOCK gene variants associate with sleep duration in two independent populations.
Allebrandt, K.V., Teder-Laving, M., Akyol, M., Pichler, I., Müller-Myhsok, B., Pramstaller, P., Merrow, M., Meitinger, T., Metspalu, A. & Roenneberg, T.
Published in: Biological psychiatry 67, 1040-7

Manifesto for a European anxiety disorders research network.
Baldwin, D.S., Allgulander, C., Altamura, A.C., Angst, J., Bandelow, B., den Boer, J., Boyer, P., Davies, S., Dell’osso, B., Eriksson, E., Fineberg, N., Fredrikson, M., Herran, A., Maron, E., Metspalu, A., Nutt, D., van der Wee, N., Vázquez-Barquero, J.L. & Zohar, J.
Published in: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20, 426-32

Unique spectrum of SPAST variants in Estonian HSP patients: presence of benign missense changes but lack of exonic rearrangements.
Braschinsky, M., Tamm, R., Beetz, C., Sachez-Ferrero, E., Raukas, E., Lüüs, S.-M., Gross-Paju, K., Boillot, C., Canzian, F., Metspalu, A. & Haldre, S.
Published in: BMC neurology 10, 17

Meta-analysis of genome-wide association studies for personality.
de Moor, M.H.M., Costa, P.T., Terracciano, A., Krueger, R.F., de Geus, E.J.C., Toshiko, T., Penninx, B.W.J.H., Esko, T., Madden, P.A.F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J.-J., Distel, M.A., Uda, M., Sanna, S., Spinhoven, P., Hartman, C.A., Sullivan, P., Realo, A., Allik, J., Heath, A.C., Pergadia, M.L., Agrawal, A., Lin, P., Grucza, R., Nutile, T., Ciullo, M., Rujescu, D., Giegling, I., Konte, B., Widen, E., Cousminer, D.L., Eriksson, J.G., Palotie, A., Peltonen, L., Luciano, M., Tenesa, A., Davies, G., Lopez, L.M., Hansell, N.K., Medland, S.E., Ferrucci, L., Schlessinger, D., Montgomery, G.W., Wright, M.J., Aulchenko, Y.S., Janssens, A.C.J.W., Oostra, B.A., Metspalu, A., Abecasis, G.R., Deary, I.J., Räikkönen, K., Bierut, L.J., Martin, N.G., van Duijn, C.M. & Boomsma, D.I.
Published in: Molecular psychiatry

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
Elks, C.E., Perry, J.R.B., Sulem, P., Chasman, D.I., Franceschini, N., He, C., Lunetta, K.L., Visser, J.A., Byrne, E.M., Cousminer, D.L., Gudbjartsson, D.F., Esko, T., Feenstra, B., Hottenga, J.-J., Koller, D.L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M., McArdle, P.F., Smith, A.V., Stolk, L., van Wingerden, S.H., Zhao, J.H., Albrecht, E., Corre, T., Ingelsson, E., Hayward, C., Magnusson, P.K.E., Smith, E.N., Ulivi, S., Warrington, N.M., Zgaga, L., Alavere, H., Amin, N., Aspelund, T., Bandinelli, S., Barroso, I., Berenson, G.S., Bergmann, S., Blackburn, H., Boerwinkle, E., Buring, J.E., Busonero, F., Campbell, H., Chanock, S.J., Chen, W., Cornelis, M.C., Couper, D., Coviello, A.D., d’ Adamo, P., de Faire, U., de Geus, E.J.C., Deloukas, P., Döring, A., Smith, G.D., Easton, D.F., Eiriksdottir, G., Emilsson, V., Eriksson, J., Ferrucci, L., Folsom, A.R., Foroud, T., Garcia, M., Gasparini, P., Geller, F., Gieger, C., Gudnason, V., Hall, P., Hankinson, S.E., Ferreli, L., Heath, A.C., Hernandez, D.G., Hofman, A., Hu, F.B., Illig, T., Järvelin, M.-R., Johnson, A.D., Karasik, D., Khaw, K.-T., Kiel, D.P., Kilpeläinen, T.O., Kolcic, I., Kraft, P., Launer, L.J., Laven, J.S.E., Li, S., Liu, J., Levy, D., Martin, N.G., McArdle, W.L., Melbye, M., Mooser, V., Murray, J.C., Murray, S.S., Nalls, M.A., Navarro, P., Nelis, M., Ness, A.R., Northstone, K., Oostra, B.A., Peacock, M., Palmer, L.J., Palotie, A., Paré, G., Parker, A.N., Pedersen, N.L., Peltonen, L., Pennell, C.E., Pharoah, P., Polasek, O., Plump, A.S., Pouta, A., Porcu, E., Rafnar, T., Rice, J.P., Ring, S.M., Rivadeneira, F., Rudan, I., Sala, C., Salomaa, V., Sanna, S., Schlessinger, D., Schork, N.J., Scuteri, A., Segrè, A.V., Shuldiner, A.R., Soranzo, N., Sovio, U., Srinivasan, S.R., Strachan, D.P., Tammesoo, M.-L., Tikkanen, E., Toniolo, D., Tsui, K., Tryggvadottir, L., Tyrer, J., Uda, M., van Dam, R.M., van Meurs, J.B.J., Vollenweider, P., Waeber, G., Wareham, N.J., Waterworth, D.M., Weedon, M.N., Wichmann, H.E., Willemsen, G., Wilson, J.F., Wright, A.F., Young, L., Zhai, G., Zhuang, W.V., Bierut, L.J., Boomsma, D.I., Boyd, H.A., Crisponi, L., Demerath, E.W., van Duijn, C.M., Econs, M.J., Harris, T.B., Hunter, D.J., Loos, R.J.F., Metspalu, A., Montgomery, G.W., Ridker, P.M., Spector, T.D., Streeten, E.A., Stefansson, K., Thorsteinsdottir, U., Uitterlinden, A.G., Widen, E., Murabito, J.M., Ong, K.K. & Murray, A.
Published in: Nature genetics 42, 1077-85

Common variants in KCNN3 are associated with lone atrial fibrillation.
Ellinor, P.T., Lunetta, K.L., Glazer, N.L., Pfeufer, A., Alonso, A., Chung, M.K., Sinner, M.F., de Bakker, P.I.W., Mueller, M., Lubitz, S.A., Fox, E., Darbar, D., Smith, N.L., Smith, J.D., Schnabel, R.B., Soliman, E.Z., Rice, K.M., Van Wagoner, D.R., Beckmann, B.-M., van Noord, C., Wang, K., Ehret, G.B., Rotter, J.I., Hazen, S.L., Steinbeck, G., Smith, A.V., Launer, L.J., Harris, T.B., Makino, S., Nelis, M., Milan, D.J., Perz, S., Esko, T., Köttgen, A., Moebus, S., Newton-Cheh, C., Li, M., Möhlenkamp, S., Wang, T.J., Kao, W.H.L., Vasan, R.S., Nöthen, M.M., MacRae, C.A., Stricker, B.H.C., Hofman, A., Uitterlinden, A.G., Levy, D., Boerwinkle, E., Metspalu, A., Topol, E.J., Chakravarti, A., Gudnason, V., Psaty, B.M., Roden, D.M., Meitinger, T., Wichmann, H.-E., Witteman, J.C.M., Barnard, J., Arking, D.E., Benjamin, E.J., Heckbert, S.R. & Kääb, S.
Published in: Nature genetics 42, 240-4

Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies.
Fortier, I., Burton, P.R., Robson, P.J., Ferretti, V., Little, J., L’Heureux, F., Deschênes, M., Knoppers, B.M., Doiron, D., Keers, J.C., Linksted, P., Harris, J.R., Lachance, G., Boileau, C., Pedersen, N.L., Hamilton, C.M., Hveem, K., Borugian, M.J., Gallagher, R.P., McLaughlin, J., Parker, L., Potter, J.D., Gallacher, J., Kaaks, R., Liu, B., Sprosen, T., Vilain, A., Atkinson, S.A., Rengifo, A., Morton, R., Metspalu, A., Wichmann, H.E., Tremblay, M., Chisholm, R.L., Garcia-Montero, A., Hillege, H., Litton, J.-E., Palmer, L.J., Perola, M., Wolffenbuttel, B.H.R., Peltonen, L. & Hudson, T.J.
Published in: International journal of epidemiology 39, 1383-93

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Mägi, R., Workalemahu, T., White, C.C., Bouatia-Naji, N., Harris, T.B., Berndt, S.I., Ingelsson, E., Willer, C.J., Weedon, M.N., Luan, J., Vedantam, S., Esko, T., Kilpeläinen, T.O., Kutalik, Z., Li, S., Monda, K.L., Dixon, A.L., Holmes, C.C., Kaplan, L.M., Liang, L., Min, J.L., Moffatt, M.F., Molony, C., Nicholson, G., Schadt, E.E., Zondervan, K.T., Feitosa, M.F., Ferreira, T., Allen, H.L., Weyant, R.J., Wheeler, E., Wood, A.R., Estrada, K., Goddard, M.E., Lettre, G., Mangino, M., Nyholt, D.R., Purcell, S., Smith, A.V., Visscher, P.M., Yang, J., McCarroll, S.A., Nemesh, J., Voight, B.F., Absher, D., Amin, N., Aspelund, T., Coin, L., Glazer, N.L., Hayward, C., Heard-Costa, N.L., Hottenga, J.-J., Johansson, A., Johnson, T., Kaakinen, M., Kapur, K., Ketkar, S., Knowles, J.W., Kraft, P., Kraja, A.T., Lamina, C., Leitzmann, M.F., McKnight, B., Morris, A.P., Ong, K.K., Perry, J.R.B., Peters, M.J., Polasek, O., Prokopenko, I., Rayner, N.W., Ripatti, S., Rivadeneira, F., Robertson, N.R., Sanna, S., Sovio, U., Surakka, I., Teumer, A., van Wingerden, S., Vitart, V., Zhao, J.H., Cavalcanti-Proença, C., Chines, P.S., Fisher, E., Kulzer, J.R., Lecoeur, C., Narisu, N., Sandholt, C., Scott, L.J., Silander, K., Stark, K., Tammesoo, M.-L., Teslovich, T.M., Timpson, N.J., Watanabe, R.M., Welch, R., Chasman, D.I., Cooper, M.N., Jansson, J.-O., Kettunen, J., Lawrence, R.W., Pellikka, N., Perola, M., Vandenput, L., Alavere, H., Almgren, P., Atwood, L.D., Bennett, A.J., Biffar, R., Bonnycastle, L.L., Bornstein, S.R., Buchanan, T.A., Campbell, H., Day, I.N.M., Dei, M., Dörr, M., Elliott, P., Erdos, M.R., Eriksson, J.G., Freimer, N.B., Fu, M., Gaget, S., Geus, E.J.C., Gjesing, A.P., Grallert, H., Grässler, J., Groves, C.J., Guiducci, C., Hartikainen, A.-L., Hassanali, N., Havulinna, A.S., Herzig, K.-H., Hicks, A.A., Hui, J., Igl, W., Jousilahti, P., Jula, A., Kajantie, E., Kinnunen, L., Kolcic, I., Koskinen, S., Kovacs, P., Kroemer, H.K., Krzelj, V., Kuusisto, J., Kvaloy, K., Laitinen, J., Lantieri, O., Lathrop, G.M., Lokki, M.-L., Luben, R.N., Ludwig, B., McArdle, W.L., McCarthy, A., Morken, M.A., Nelis, M., Neville, M.J., Paré, G., Parker, A.N., Peden, J.F., Pichler, I., Pietiläinen, K.H., Platou, C.G.P., Pouta, A., Ridderstråle, M., Samani, N.J., Saramies, J., Sinisalo, J., Smit, J.H., Strawbridge, R.J., Stringham, H.M., Swift, A.J., Teder-Laving, M., Thomson, B., Usala, G., van Meurs, J.B.J., van Ommen, G.-J., Vatin, V., Volpato, C.B., Wallaschofski, H., Walters, G.B., Widen, E., Wild, S.H., Willemsen, G., Witte, D.R., Zgaga, L., Zitting, P., Beilby, J.P., James, A.L., Kähönen, M., Lehtimäki, T., Nieminen, M.S., Ohlsson, C., Palmer, L.J., Raitakari, O., Ridker, P.M., Stumvoll, M., Tönjes, A., Viikari, J., Balkau, B., Ben-Shlomo, Y., Bergman, R.N., Boeing, H., Smith, G.D., Ebrahim, S., Froguel, P., Hansen, T., Hengstenberg, C., Hveem, K., Isomaa, B., Jørgensen, T., Karpe, F., Khaw, K.-T., Laakso, M., Lawlor, D.A., Marre, M., Meitinger, T., Metspalu, A., Midthjell, K., Pedersen, O., Salomaa, V., Schwarz, P.E.H., Tuomi, T., Tuomilehto, J., Valle, T.T., Wareham, N.J., Arnold, A.M., Beckmann, J.S., Bergmann, S., Boerwinkle, E., Boomsma, D.I., Caulfield, M.J., Collins, F.S., Eiriksdottir, G., Gudnason, V., Gyllensten, U., Hamsten, A., Hattersley, A.T., Hofman, A., Hu, F.B., Illig, T., Iribarren, C., Jarvelin, M.-R., Kao, W.H.L., Kaprio, J., Launer, L.J., Munroe, P.B., Oostra, B., Penninx, B.W., Pramstaller, P.P., Psaty, B.M., Quertermous, T., Rissanen, A., Rudan, I., Shuldiner, A.R., Soranzo, N., Spector, T.D., Syvanen, A.-C., Uda, M., Uitterlinden, A., Völzke, H., Vollenweider, P., Wilson, J.F., Witteman, J.C., Wright, A.F., Abecasis, G.R., Boehnke, M., Borecki, I.B., Deloukas, P., Frayling, T.M., Groop, L.C., Haritunians, T., Hunter, D.J., Kaplan, R.C., North, K.E., O’Connell, J.R., Peltonen, L., Schlessinger, D., Strachan, D.P., Hirschhorn, J.N., Assimes, T.L., Wichmann, H.-E., Thorsteinsdottir, U., van Duijn, C.M., Stefansson, K., Cupples, L.A., Loos, R.J.F., Barroso, I., McCarthy, M.I., Fox, C.S., Mohlke, K.L. & Lindgren, C.M.
Published in: Nature genetics 42, 949-60

MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.
Jagomägi, T., Nikopensius, T., Krjutskov, K., Tammekivi, V., Viltrop, T., Saag, M. & Metspalu, A.
Published in: European journal of oral sciences 118, 213-20

Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with cardiovascular traits.
Kepp, K., Org, E., Sõber, S., Kelgo, P., Viigimaa, M., Veldre, G., Tõnisson, N., Juhanson, P., Putku, M., Kindmark, A., Kozich, V. & Laan, M.
Published in: BMC medical genetics 11, 15

Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Lango Allen, H., Estrada, K., Lettre, G., Berndt, S.I., Weedon, M.N., Rivadeneira, F., Willer, C.J., Jackson, A.U., Vedantam, S., Raychaudhuri, S., Ferreira, T., Wood, A.R., Weyant, R.J., Segrè, A.V., Speliotes, E.K., Wheeler, E., Soranzo, N., Park, J.-H., Yang, J., Gudbjartsson, D., Heard-Costa, N.L., Randall, J.C., Qi, L., Vernon Smith, A., Mägi, R., Pastinen, T., Liang, L., Heid, I.M., Luan, J., Thorleifsson, G., Winkler, T.W., Goddard, M.E., Sin Lo, K., Palmer, C., Workalemahu, T., Aulchenko, Y.S., Johansson, A., Zillikens, M.C., Feitosa, M.F., Esko, T., Johnson, T., Ketkar, S., Kraft, P., Mangino, M., Prokopenko, I., Absher, D., Albrecht, E., Ernst, F., Glazer, N.L., Hayward, C., Hottenga, J.-J., Jacobs, K.B., Knowles, J.W., Kutalik, Z., Monda, K.L., Polasek, O., Preuss, M., Rayner, N.W., Robertson, N.R., Steinthorsdottir, V., Tyrer, J.P., Voight, B.F., Wiklund, F., Xu, J., Zhao, J.H., Nyholt, D.R., Pellikka, N., Perola, M., Perry, J.R.B., Surakka, I., Tammesoo, M.-L., Altmaier, E.L., Amin, N., Aspelund, T., Bhangale, T., Boucher, G., Chasman, D.I., Chen, C., Coin, L., Cooper, M.N., Dixon, A.L., Gibson, Q., Grundberg, E., Hao, K., Juhani Junttila, M., Kaplan, L.M., Kettunen, J., König, I.R., Kwan, T., Lawrence, R.W., Levinson, D.F., Lorentzon, M., McKnight, B., Morris, A.P., Müller, M., Suh Ngwa, J., Purcell, S., Rafelt, S., Salem, R.M., Salvi, E., Sanna, S., Shi, J., Sovio, U., Thompson, J.R., Turchin, M.C., Vandenput, L., Verlaan, D.J., Vitart, V., White, C.C., Ziegler, A., Almgren, P., Balmforth, A.J., Campbell, H., Citterio, L., De Grandi, A., Dominiczak, A., Duan, J., Elliott, P., Elosua, R., Eriksson, J.G., Freimer, N.B., Geus, E.J.C., Glorioso, N., Haiqing, S., Hartikainen, A.-L., Havulinna, A.S., Hicks, A.A., Hui, J., Igl, W., Illig, T., Jula, A., Kajantie, E., Kilpeläinen, T.O., Koiranen, M., Kolcic, I., Koskinen, S., Kovacs, P., Laitinen, J., Liu, J., Lokki, M.-L., Marusic, A., Maschio, A., Meitinger, T., Mulas, A., Paré, G., Parker, A.N., Peden, J.F., Petersmann, A., Pichler, I., Pietiläinen, K.H., Pouta, A., Ridderstråle, M., Rotter, J.I., Sambrook, J.G., Sanders, A.R., Schmidt, C.O., Sinisalo, J., Smit, J.H., Stringham, H.M., Bragi Walters, G., Widen, E., Wild, S.H., Willemsen, G., Zagato, L., Zgaga, L., Zitting, P., Alavere, H., Farrall, M., McArdle, W.L., Nelis, M., Peters, M.J., Ripatti, S., van Meurs, J.B.J., Aben, K.K., Ardlie, K.G., Beckmann, J.S., Beilby, J.P., Bergman, R.N., Bergmann, S., Collins, F.S., Cusi, D., den Heijer, M., Eiriksdottir, G., Gejman, P.V., Hall, A.S., Hamsten, A., Huikuri, H.V., Iribarren, C., Kähönen, M., Kaprio, J., Kathiresan, S., Kiemeney, L., Kocher, T., Launer, L.J., Lehtimäki, T., Melander, O., Mosley, T.H., Musk, A.W., Nieminen, M.S., O’Donnell, C.J., Ohlsson, C., Oostra, B., Palmer, L.J., Raitakari, O., Ridker, P.M., Rioux, J.D., Rissanen, A., Rivolta, C., Schunkert, H., Shuldiner, A.R., Siscovick, D.S., Stumvoll, M., Tönjes, A., Tuomilehto, J., van Ommen, G.-J., Viikari, J., Heath, A.C., Martin, N.G., Montgomery, G.W., Province, M.A., Kayser, M., Arnold, A.M., Atwood, L.D., Boerwinkle, E., Chanock, S.J., Deloukas, P., Gieger, C., Grönberg, H., Hall, P., Hattersley, A.T., Hengstenberg, C., Hoffman, W., Lathrop, G.M., Salomaa, V., Schreiber, S., Uda, M., Waterworth, D., Wright, A.F., Assimes, T.L., Barroso, I., Hofman, A., Mohlke, K.L., Boomsma, D.I., Caulfield, M.J., Cupples, L.A., Erdmann, J., Fox, C.S., Gudnason, V., Gyllensten, U., Harris, T.B., Hayes, R.B., Jarvelin, M.-R., Mooser, V., Munroe, P.B., Ouwehand, W.H., Penninx, B.W., Pramstaller, P.P., Quertermous, T., Rudan, I., Samani, N.J., Spector, T.D., Völzke, H., Watkins, H., Wilson, J.F., Groop, L.C., Haritunians, T., Hu, F.B., Kaplan, R.C., Metspalu, A., North, K.E., Schlessinger, D., Wareham, N.J., Hunter, D.J., O’Connell, J.R., Strachan, D.P., Wichmann, H.-E., Borecki, I.B., van Duijn, C.M., Schadt, E.E., Thorsteinsdottir, U., Peltonen, L., Uitterlinden, A.G., Visscher, P.M., Chatterjee, N., Loos, R.J.F., Boehnke, M., McCarthy, M.I., Ingelsson, E., Lindgren, C.M., Abecasis, G.R., Stefansson, K., Frayling, T.M. & Hirschhorn, J.N.
Published in: Nature 467, 832-8

Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals.
Lips, E.H., Gaborieau, V., McKay, J.D., Chabrier, A., Hung, R.J., Boffetta, P., Hashibe, M., Zaridze, D., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Field, J.K., Liloglou, T., Xinarianos, G., McLaughlin, J., Liu, G., Skorpen, F., Elvestad, M.B., Hveem, K., Vatten, L., Study, E., Benhamou, S., Lagiou, P., Holcátová, I., Merletti, F., Kjaerheim, K., Agudo, A., Castellsagué, X., Macfarlane, T.V., Barzan, L., Canova, C., Lowry, R., Conway, D.I., Znaor, A., Healy, C., Curado, M.P., Koifman, S., Eluf-Neto, J., Matos, E., Menezes, A., Fernandez, L., Metspalu, A., Heath, S., Lathrop, M. & Brennan, P.
Published in: International journal of epidemiology 39, 563-77

A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia.
Männik, K., Parkel, S., Palta, P., Zilina, O., Puusepp, H., Esko, T., Mägi, R., Nõukas, M., Veidenberg, A., Nelis, M., Metspalu, A., Remm, M., Ounap, K. & Kurg, A.
Published in: European journal of medical genetics 54, 136-43

Advances in molecular genetics of panic disorder.
Maron, E., Hettema, J.M. & Shlik, J.
Published in: Molecular psychiatry 15, 681-701

Peripheral gene expression profiling of CCK-4-induced panic in healthy subjects.
Maron, E., Kallassalu, K., Tammiste, A., Kolde, R., Vilo, J., Tõru, I., Vasar, V., Shlik, J. & Metspalu, A.
Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 153B, 269-74

Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patients.
Nikopensius, T., Birnbaum, S., Ludwig, K.U., Jagomägi, T., Saag, M., Herms, S., Knapp, M., Hoffmann, P., Nöthen, M.M., Metspalu, A. & Mangold, E.
Published in: European journal of oral sciences 118, 317-9

Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.
Nikopensius, T., Jagomägi, T., Krjutskov, K., Tammekivi, V., Saag, M., Prane, I., Piekuse, L., Akota, I., Barkane, B., Krumina, A., Ambrozaityte, L., Matuleviciene, A., Kucinskiene, Z.A., Lace, B., Kucinskas, V. & Metspalu, A.
Published in: Birth defects research. Part A, Clinical and molecular teratology 88, 748-56

HGV2009 meeting: bigger and better studies provide more answers and more questions.
Reekie, K., Metspalu, A., Chanock, S.J., Liu, E.T., Mardis, E.R., Scherer, S.W., Kwok, P.-Y. & Brookes, A.J.
Published in: Human mutation 31, 886-8

Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis.
Saare, M., Lamp, M., Kaart, T., Karro, H., Kadastik, U., Metspalu, A., Peters, M. & Salumets, A.
Published in: Fertility and sterility 94, 1560-3

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Allen, H.L., Lindgren, C.M., Luan, J., Mägi, R., Randall, J.C., Vedantam, S., Winkler, T.W., Qi, L., Workalemahu, T., Heid, I.M., Steinthorsdottir, V., Stringham, H.M., Weedon, M.N., Wheeler, E., Wood, A.R., Ferreira, T., Weyant, R.J., Segrè, A.V., Estrada, K., Liang, L., Nemesh, J., Park, J.-H., Gustafsson, S., Kilpeläinen, T.O., Yang, J., Bouatia-Naji, N., Esko, T., Feitosa, M.F., Kutalik, Z., Mangino, M., Raychaudhuri, S., Scherag, A., Smith, A.V., Welch, R., Zhao, J.H., Aben, K.K., Absher, D.M., Amin, N., Dixon, A.L., Fisher, E., Glazer, N.L., Goddard, M.E., Heard-Costa, N.L., Hoesel, V., Hottenga, J.-J., Johansson, A., Johnson, T., Ketkar, S., Lamina, C., Li, S., Moffatt, M.F., Myers, R.H., Narisu, N., Perry, J.R.B., Peters, M.J., Preuss, M., Ripatti, S., Rivadeneira, F., Sandholt, C., Scott, L.J., Timpson, N.J., Tyrer, J.P., van Wingerden, S., Watanabe, R.M., White, C.C., Wiklund, F., Barlassina, C., Chasman, D.I., Cooper, M.N., Jansson, J.-O., Lawrence, R.W., Pellikka, N., Prokopenko, I., Shi, J., Thiering, E., Alavere, H., Alibrandi, M.T.S., Almgren, P., Arnold, A.M., Aspelund, T., Atwood, L.D., Balkau, B., Balmforth, A.J., Bennett, A.J., Ben-Shlomo, Y., Bergman, R.N., Bergmann, S., Biebermann, H., Blakemore, A.I.F., Boes, T., Bonnycastle, L.L., Bornstein, S.R., Brown, M.J., Buchanan, T.A., Busonero, F., Campbell, H., Cappuccio, F.P., Cavalcanti-Proença, C., Chen, Y.-D.I., Chen, C.-M., Chines, P.S., Clarke, R., Coin, L., Connell, J., Day, I.N.M., Heijer, M. den, Duan, J., Ebrahim, S., Elliott, P., Elosua, R., Eiriksdottir, G., Erdos, M.R., Eriksson, J.G., Facheris, M.F., Felix, S.B., Fischer-Posovszky, P., Folsom, A.R., Friedrich, N., Freimer, N.B., Fu, M., Gaget, S., Gejman, P.V., Geus, E.J.C., Gieger, C., Gjesing, A.P., Goel, A., Goyette, P., Grallert, H., Grässler, J., Greenawalt, D.M., Groves, C.J., Gudnason, V., Guiducci, C., Hartikainen, A.-L., Hassanali, N., Hall, A.S., Havulinna, A.S., Hayward, C., Heath, A.C., Hengstenberg, C., Hicks, A.A., Hinney, A., Hofman, A., Homuth, G., Hui, J., Igl, W., Iribarren, C., Isomaa, B., Jacobs, K.B., Jarick, I., Jewell, E., John, U., Jørgensen, T., Jousilahti, P., Jula, A., Kaakinen, M., Kajantie, E., Kaplan, L.M., Kathiresan, S., Kettunen, J., Kinnunen, L., Knowles, J.W., Kolcic, I., König, I.R., Koskinen, S., Kovacs, P., Kuusisto, J., Kraft, P., Kvaløy, K., Laitinen, J., Lantieri, O., Lanzani, C., Launer, L.J., Lecoeur, C., Lehtimäki, T., Lettre, G., Liu, J., Lokki, M.-L., Lorentzon, M., Luben, R.N., Ludwig, B., Manunta, P., Marek, D., Marre, M., Martin, N.G., McArdle, W.L., McCarthy, A., McKnight, B., Meitinger, T., Melander, O., Meyre, D., Midthjell, K., Montgomery, G.W., Morken, M.A., Morris, A.P., Mulic, R., Ngwa, J.S., Nelis, M., Neville, M.J., Nyholt, D.R., O’Donnell, C.J., O’Rahilly, S., Ong, K.K., Oostra, B., Paré, G., Parker, A.N., Perola, M., Pichler, I., Pietiläinen, K.H., Platou, C.G.P., Polasek, O., Pouta, A., Rafelt, S., Raitakari, O., Rayner, N.W., Ridderstråle, M., Rief, W., Ruokonen, A., Robertson, N.R., Rzehak, P., Salomaa, V., Sanders, A.R., Sandhu, M.S., Sanna, S., Saramies, J., Savolainen, M.J., Scherag, S., Schipf, S., Schreiber, S., Schunkert, H., Silander, K., Sinisalo, J., Siscovick, D.S., Smit, J.H., Soranzo, N., Sovio, U., Stephens, J., Surakka, I., Swift, A.J., Tammesoo, M.-L., Tardif, J.-C., Teder-Laving, M., Teslovich, T.M., Thompson, J.R., Thomson, B., Tönjes, A., Tuomi, T., van Meurs, J.B.J., van Ommen, G.-J., Vatin, V., Viikari, J., Visvikis-Siest, S., Vitart, V., Vogel, C.I.G., Voight, B.F., Waite, L.L., Wallaschofski, H., Walters, G.B., Widen, E., Wiegand, S., Wild, S.H., Willemsen, G., Witte, D.R., Witteman, J.C., Xu, J., Zhang, Q., Zgaga, L., Ziegler, A., Zitting, P., Beilby, J.P., Farooqi, I.S., Hebebrand, J., Huikuri, H.V., James, A.L., Kähönen, M., Levinson, D.F., Macciardi, F., Nieminen, M.S., Ohlsson, C., Palmer, L.J., Ridker, P.M., Stumvoll, M., Beckmann, J.S., Boeing, H., Boerwinkle, E., Boomsma, D.I., Caulfield, M.J., Chanock, S.J., Collins, F.S., Cupples, L.A., Smith, G.D., Erdmann, J., Froguel, P., Grönberg, H., Gyllensten, U., Hall, P., Hansen, T., Harris, T.B., Hattersley, A.T., Hayes, R.B., Heinrich, J., Hu, F.B., Hveem, K., Illig, T., Jarvelin, M.-R., Kaprio, J., Karpe, F., Khaw, K.-T., Kiemeney, L.A., Krude, H., Laakso, M., Lawlor, D.A., Metspalu, A., Munroe, P.B., Ouwehand, W.H., Pedersen, O., Penninx, B.W., Peters, A., Pramstaller, P.P., Quertermous, T., Reinehr, T., Rissanen, A., Rudan, I., Samani, N.J., Schwarz, P.E.H., Shuldiner, A.R., Spector, T.D., Tuomilehto, J., Uda, M., Uitterlinden, A., Valle, T.T., Wabitsch, M., Waeber, G., Wareham, N.J., Watkins, H., Wilson, J.F., Wright, A.F., Zillikens, M.C., Chatterjee, N., McCarroll, S.A., Purcell, S., Schadt, E.E., Visscher, P.M., Assimes, T.L., Borecki, I.B., Deloukas, P., Fox, C.S., Groop, L.C., Haritunians, T., Hunter, D.J., Kaplan, R.C., Mohlke, K.L., O’Connell, J.R., Peltonen, L., Schlessinger, D., Strachan, D.P., van Duijn, C.M., Wichmann, H.-E., Frayling, T.M., Thorsteinsdottir, U., Abecasis, G.R., Barroso, I., Boehnke, M., Stefansson, K., North, K.E., McCarthy, M.I., Hirschhorn, J.N., Ingelsson, E. & Loos, R.J.F.
Published in: Nature genetics 42, 937-48

Novel human pathological mutations. Gene symbol: SPAST. Disease: Hereditary spastic paraplegia.
Tamm, R.
Published in: Human genetics 127, 112

Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study.
Theodoraki, E.V., Nikopensius, T., Suhorutsenko, J., Peppes, V., Fili, P., Kolovou, G., Papamikos, V., Richter, D., Zakopoulos, N., Krjutskov, K., Metspalu, A. & Dedoussis, G.V.
Published in: BMC medical genetics 11, 28

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
Thorgeirsson, T.E., Gudbjartsson, D.F., Surakka, I., Vink, J.M., Amin, N., Geller, F., Sulem, P., Rafnar, T., Esko, T., Walter, S., Gieger, C., Rawal, R., Mangino, M., Prokopenko, I., Mägi, R., Keskitalo, K., Gudjonsdottir, I.H., Gretarsdottir, S., Stefansson, H., Thompson, J.R., Aulchenko, Y.S., Nelis, M., Aben, K.K., den Heijer, M., Dirksen, A., Ashraf, H., Soranzo, N., Valdes, A.M., Steves, C., Uitterlinden, A.G., Hofman, A., Tönjes, A., Kovacs, P., Hottenga, J.J., Willemsen, G., Vogelzangs, N., Döring, A., Dahmen, N., Nitz, B., Pergadia, M.L., Saez, B., De Diego, V., Lezcano, V., Garcia-Prats, M.D., Ripatti, S., Perola, M., Kettunen, J., Hartikainen, A.-L., Pouta, A., Laitinen, J., Isohanni, M., Huei-Yi, S., Allen, M., Krestyaninova, M., Hall, A.S., Jones, G.T., van Rij, A.M., Mueller, T., Dieplinger, B., Haltmayer, M., Jonsson, S., Matthiasson, S.E., Oskarsson, H., Tyrfingsson, T., Kiemeney, L.A., Mayordomo, J.I., Lindholt, J.S., Pedersen, J.H., Franklin, W.A., Wolf, H., Montgomery, G.W., Heath, A.C., Martin, N.G., Madden, P.A.F., Giegling, I., Rujescu, D., Järvelin, M.-R., Salomaa, V., Stumvoll, M., Spector, T.D., Wichmann, H.-E., Metspalu, A., Samani, N.J., Penninx, B.W., Oostra, B.A., Boomsma, D.I., Tiemeier, H., van Duijn, C.M., Kaprio, J., Gulcher, J.R., McCarthy, M.I., Peltonen, L., Thorsteinsdottir, U. & Stefansson, K.
Published in: Nature genetics 42, 448-53

Gene expression profiles of non-small cell lung cancer: survival prediction and new biomarkers.
Välk, K., Vooder, T., Kolde, R., Reintam, M.-A., Petzold, C., Vilo, J. & Metspalu, A.
Published in: Oncology 79, 283-92

Comparison of DNA extraction methods for multiplex polymerase chain reaction.
Viltrop, T., Krjutskov, K., Palta, P. & Metspalu, A.
Published in: Analytical biochemistry 398, 260-2

Gene Expression-Based Approaches in Differentiation of Metastases and Second Primary Tumour.
Vooder, T., Välk, K., Kolde, R., Roosipuu, R., Vilo, J. & Metspalu, A.
Published in: Case reports in oncology 3, 255-261

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.
Walters, R.G., Jacquemont, S., Valsesia, A., de Smith, A.J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., Delobel, B., Stutzmann, F., El-Sayed Moustafa, J.S., Chèvre, J.-C., Lecoeur, C., Vatin, V., Bouquillon, S., Buxton, J.L., Boute, O., Holder-Espinasse, M., Cuisset, J.-M., Lemaitre, M.-P., Ambresin, A.-E., Brioschi, A., Gaillard, M., Giusti, V., Fellmann, F., Ferrarini, A., Hadjikhani, N., Campion, D., Guilmatre, A., Goldenberg, A., Calmels, N., Mandel, J.-L., Le Caignec, C., David, A., Isidor, B., Cordier, M.-P., Dupuis-Girod, S., Labalme, A., Sanlaville, D., Béri-Dexheimer, M., Jonveaux, P., Leheup, B., Ounap, K., Bochukova, E.G., Henning, E., Keogh, J., Ellis, R.J., Macdermot, K.D., van Haelst, M.M., Vincent-Delorme, C., Plessis, G., Touraine, R., Philippe, A., Malan, V., Mathieu-Dramard, M., Chiesa, J., Blaumeiser, B., Kooy, R.F., Caiazzo, R., Pigeyre, M., Balkau, B., Sladek, R., Bergmann, S., Mooser, V., Waterworth, D., Reymond, A., Vollenweider, P., Waeber, G., Kurg, A., Palta, P., Esko, T., Metspalu, A., Nelis, M., Elliott, P., Hartikainen, A.-L., McCarthy, M.I., Peltonen, L., Carlsson, L., Jacobson, P., Sjöström, L., Huang, N., Hurles, M.E., O’Rahilly, S., Farooqi, I.S., Männik, K., Jarvelin, M.-R., Pattou, F., Meyre, D., Walley, A.J., Coin, L.J.M., Blakemore, A.I.F., Froguel, P. & Beckmann, J.S.
Published in: Nature 463, 671-5

Variance determines self-observer agreement on the Big Five personality traits.
Allik, J., Realo, A., Mõttus, R., Esko, T., Pullat, J. & Metspalu, A.
Published in: Journal of Research in Personality 44, 4, 421-426

Hereditaarset spastilist parapleegiat süsteemselt käsitlenud uuring Eestis tõi esile uusi andmeid.
Braschinsky, M., Rannikmäe, K., Tamm, R., Metspalu, A., Gross-Paju, K. & Haldre, S.
Published in: Eesti Arst, 89(3), 165-170

2009 (10)

Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Canova, C., Hashibe, M., Simonato, L., Nelis, M., Metspalu, A., Lagiou, P., Trichopoulos, D., Ahrens, W., Pigeot, I., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Macfarlane, G.J., Macfarlane, T.V., Holcátová, I., Bencko, V., Benhamou, S., Bouchardy, C., Kjaerheim, K., Lowry, R., Agudo, A., Castellsagué, X., Conway, D.I., McKinney, P.A., Znaor, A., McCartan, B.E., Healy, C.M., Marron, M. & Brennan, P.
Published in: Cancer research 69, 2956-65

Analysis of allele and haplotype diversity across 25 genomic regions in three Eastern European populations.
Khrunin, A., Mihailov, E., Nikopensius, T., Krjutskov, K., Limborska, S. & Metspalu, A.
Published in: Human heredity 68, 35-44

Evaluation of the 124-plex SNP typing microarray for forensic testing.
Krjutskov, K., Viltrop, T., Palta, P., Metspalu, E., Tamm, E., Suvi, S., Sak, K., Merilo, A., Sork, H., Teek, R., Nikopensius, T., Kivisild, T. & Metspalu, A.
Published in: Forensic science international. Genetics 4, 43-8

Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.
Kuningas, M., May, L., Tamm, R., van Bodegom, D., van den Biggelaar, A.H.J., Meij, J.J., Frölich, M., Ziem, J.B., Suchiman, H.E.D., Metspalu, A., Slagboom, P.E. & Westendorp, R.G.J.
Published in: PloS one 4, e7795

Alcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection.
Lagiou, P., Georgila, C., Minaki, P., Ahrens, W., Pohlabeln, H., Benhamou, S., Bouchardy, C., Slamova, A., Schejbalova, M., Merletti, F., Richiardi, L., Kjaerheim, K., Agudo, A., Castellsague, X., Macfarlane, T.V., Macfarlane, G.J., Talamini, R., Barzan, L., Canova, C., Simonato, L., Lowry, R., Conway, D.I., McKinney, P.A., Znaor, A., McCartan, B.E., Healy, C., Nelis, M., Metspalu, A., Marron, M., Hashibe, M. & Brennan, P.J.
Published in: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 18, 76-84

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
Landi, M.T., Chatterjee, N., Yu, K., Goldin, L.R., Goldstein, A.M., Rotunno, M., Mirabello, L., Jacobs, K., Wheeler, W., Yeager, M., Bergen, A.W., Li, Q., Consonni, D., Pesatori, A.C., Wacholder, S., Thun, M., Diver, R., Oken, M., Virtamo, J., Albanes, D., Wang, Z., Burdette, L., Doheny, K.F., Pugh, E.W., Laurie, C., Brennan, P., Hung, R., Gaborieau, V., McKay, J.D., Lathrop, M., McLaughlin, J., Wang, Y., Tsao, M.-S., Spitz, M.R., Wang, Y., Krokan, H., Vatten, L., Skorpen, F., Arnesen, E., Benhamou, S., Bouchard, C., Metspalu, A., Metsapalu, A., Vooder, T., Nelis, M., Välk, K., Field, J.K., Chen, C., Goodman, G., Sulem, P., Thorleifsson, G., Rafnar, T., Eisen, T., Sauter, W., Rosenberger, A., Bickeböller, H., Risch, A., Chang-Claude, J., Wichmann, H.E., Stefansson, K., Houlston, R., Amos, C.I., Fraumeni, J.F., Savage, S.A., Bertazzi, P.A., Tucker, M.A., Chanock, S. & Caporaso, N.E.
Published in: American journal of human genetics 85, 679-91

Serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression.
Maron, E., Tammiste, A., Kallassalu, K., Eller, T., Vasar, V., Nutt, D.J. & Metspalu, A.
Published in: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 19, 451-6

Genetic structure of Europeans: a view from the North-East.
Nelis, M., Esko, T., Mägi, R., Zimprich, F., Zimprich, A., Toncheva, D., Karachanak, S., Piskácková, T., Balascák, I., Peltonen, L., Jakkula, E., Rehnström, K., Lathrop, M., Heath, S., Galan, P., Schreiber, S., Meitinger, T., Pfeufer, A., Wichmann, H.-E., Melegh, B., Polgár, N., Toniolo, D., Gasparini, P., D’Adamo, P., Klovins, J., Nikitina-Zake, L., Kucinskas, V., Kasnauskiene, J., Lubinski, J., Debniak, T., Limborska, S., Khrunin, A., Estivill, X., Rabionet, R., Marsal, S., Julià, A., Antonarakis, S.E., Deutsch, S., Borel, C., Attar, H., Gagnebin, M., Macek, M., Krawczak, M., Remm, M. & Metspalu, A.
Published in: PloS one 4, e5472

Replication of novel susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 in Estonian and Lithuanian patients.
Nikopensius, T., Ambrozaityte, L., Ludwig, K.U., Birnbaum, S., Jagomägi, T., Saag, M., Matuleviciene, A., Linkeviciene, L., Herms, S., Knapp, M., Hoffmann, P., Nöthen, M.M., Kucinskas, V., Metspalu, A. & Mangold, E.
Published in: American journal of medical genetics. Part A 149A, 2551-3

ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study.
Theodoraki, E.V., Nikopensius, T., Suhorutsenko, J., Papamikos, V., Kolovou, G.D., Peppes, V., Panagiotakos, D., Limberi, S., Zakopoulos, N., Metspalu, A. & Dedoussis, G.V.
Published in: Clinical chemistry and laboratory medicine : CCLM / FESCC 47, 1471-3

2008 (6)

Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays.
Krjutskov, K., Andreson, R., Mägi, R., Nikopensius, T., Khrunin, A., Mihailov, E., Tammekivi, V., Sork, H., Remm, M. & Metspalu, A.
Published in: Nucleic acids research 36, e75

Arrayed primer extension on in situ synthesized 5’-->3’ oligonucleotides in microchannels.
Pullat, J., Kusnezow, W., Jaakson, K., Beier, M., Hoheisel, J.D. & Metspalu, A.
Published in: New biotechnology 25, 133-41

Arrayed primer extension reaction for genotyping on oligonucleotide microarray.
Pullat, J. & Metspalu, A.
Published in: Methods in molecular biology (Clifton, N.J.) 444, 161-7

Androgen receptor gene haplotype is associated with male infertility.
Saare, M., Belousova, A., Punab, M., Peters, M., Haller, K., Ausmees, K., Poolamets, O., Karro, H., Metspalu, A. & Salumets, A.
Published in: International journal of andrology 31, 395-402

Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population.
Tamm, R., Oselin, K., Kallassalu, K., Magi, R., Anier, K., Remm, M. & Metspalu, A.
Published in: Clinical chemistry and laboratory medicine : CCLM / FESCC 46, 974-9

Aromatase gene (CYP19A1) allele variants are essential to controlled ovarian hyperstimulation outcome
Altmäe, S., Haller, K., Peters, M., Saare, M., Hovatta, O., Stavreus-Evers, A., Velthut, A., Karro, H., Metspalu, A. & Salumets, A.
Published in: RBMOnline, Volume 17, No 3

2007 (2)

Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization.
Altmäe, S., Haller, K., Peters, M., Hovatta, O., Stavreus-Evers, A., Karro, H., Metspalu, A. & Salumets, A.
Published in: Molecular human reproduction 13, 521-6

Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
Pullat, J., Fleischer, R., Becker, N., Beier, M., Metspalu, A. & Hoheisel, J.D.
Published in: BMC genomics 8, 282

2005 (1)

L''Estonie parie sur les biotechnologies.
Eensaar, R. & Metspalu, A.
Published in: Biofutur 257: 51-54

2004 (2)

[The Estonian Genome Project in the context of European genome research]
Metspalu, A., Köhler, F., Laschinski, G., Ganten, D. & Roots, I.
Published in: Deutsche medizinische Wochenschrift (1946) 129 Suppl , S25-8

The Estonian Genome Project.
Metspalu, A.
Published in: Drug Development Research 62, 97-101

2002 (2)

Estonian Genome Project--before the take-off and take-off.
Metspalu, A.
Published in: Bioinformatics (Oxford, England) 18 Suppl 2, S152

Comment to: Pálsson, G. and Hardardóttir "For Whom the Cell Tolls"
Metspalu, A.
Published in: Current Anthropology 43, 2