In-depth genetic and epigenetic analyses of genes

In-depth genetic and epigenetic analyses of genes involved in drug metabolism by next-generation sequencing
Duration: 01.01.2012 - 31.12.2015
Grant no: ETF9293
Financial program: GP1GV9293
The aim of this research project is to identify genetic and epigenetic signatures that control interindividual variation in drug metabolism and response. We will use ultra high-throughput sequencing technology to identify novel genetic and epigenetic variation in regulatory and protein coding regions of major genes involved in drug absorbtion, distribution, metabolism and excretion. We will study a unique collection of Caucasian liver samples, which have been extensively phenotyped for the activity and expression levels of different drug metabolizing enzymes. The identified variants will be further examined in samples from the Estonian Genome Center to verify their frequency and effect in a wider population. If successful, our approach will reveal previously unknown genetic variants associated with drug metabolism, which can be applied as pharmacogenetic markers to design optimal treatment for patients.

BiomarCaRE

Biomarker for Cardiovascular Risk Assessment in Europe
Duration: November 2011 - September 2015
Grant no: FP7 grant 278913
Financial program: FP7-HEALTH-2011.2.4.2-2
www.biomarcare.eu

EUSARNAD

Joint European and South African Research Network in Anxiety Disorders
Duration: November 2011 - March 2013
Grant no: FP7 grant 269213
Financial program: FP7-PEOPLE-2010-IRSES
Funding scheme; Marie Curie Actions—International Research Staff Exchange Scheme (IRSES)

EuroEPINOMICS

Genetics of rare epilepsy syndromes (RES)
Duration: June 2011 - May 2014
Grant no: ESF grant
Financial program: EUROCORES program
www.esf.org/activities/eurocores/running-programmes/euroepinomics/projects/res.html

OPENGENE

Opening Estonian Genome Project for European Research Area
Duration: December 2009 - November 2012
Financial program: FP7-REGPOT-2009-1
www.geenivaramu.ee/opengene/

BBMRI

Biobanking and Biomolecular Resources Research Infrastructure
Duration: February 2008 - July 2010
Grant no: FP7-INFRASTRUCTURES-2007
www.bbmri.eu

ENGAGE

European Network for Genetic and Genomic Epidemiology
Duration: January 2008 - December 2012
Financial program: FP7-HEALTH CP Collaborative Project
www.euengage.org

IDAMES

Innovative Dietary Assessment Methods in Epidemiological Studies and Public Health
Duration: April 2007 - September 2009
Financial program: Public Health Program
www.idames.eu

PHOEBE

Harmonising Population-BasedBiobanks and Cohort Studies to Strengthen the Foundation of Biomedical Science in the Post-Genome Era
Duration: March 2006 - August 2009
Financial program: FP6 Priority 1
www.phoebe-eu.org

ScanBalt Campus

A European Model Case for Transnational Institution Building in Education Research and Development
Duration: July 2005 - June 2007
Financial program: Baltic Sea Region INTERREG IIIB

HeCaPrev EE LV

Development of Hereditary Cancer Prevention Measures in Estonia and Latvia
Duration: March 2005 - November 2007
Financial program: INTERREG Regional Development Fund INTERREG IIIA

ScanBalt Clinical Research Network

Duration: March 2005 - January 2006
Financial program: Nordic Innovations Center
Coordinator: Estonian Genome Project Foundation

CTG

The Center of Translational Genomics
www.ctg.ut.ee