Publikatsioonid 2002-2013 | Tartu Ülikooli Eesti geenivaramu
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TÜ üksuste kontaktandmed

humanitaarteaduste ja kunstide valdkond
Faculty phone: 
(+372) 737 5341
Faculty address: 
Jakobi 2 - 116-121, 51014, Tartu
  • ajaloo ja arheoloogia instituut
    Faculty phone: 
    (+372) 737 5651
    Faculty address: 
    Jakobi 2, 51003, Tartu
  • eesti ja üldkeeleteaduse instituut
    Faculty phone: 
    (+372) 737 5221
    Faculty address: 
    Jakobi 2, IV korrus, 51014, Tartu
  • filosoofia ja semiootika instituut
    Faculty phone: 
    (+372) 737 5314
    Faculty address: 
    Jakobi 2, III korrus, ruumid 309-352, 51014, Tartu
  • kultuuriteaduste ja kunstide instituut
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003, Tartu
  • maailma keelte ja kultuuride kolledž
    Faculty address: 
    Lossi 3, 51003, Tartu
  • usuteaduskond
    Faculty phone: 
    (+372) 737 5300
    Faculty address: 
    Ülikooli 18-310, 50090, Tartu
  • Viljandi kultuuriakadeemia
    Faculty phone: 
    (+372) 435 5232
    Faculty address: 
    Posti 1, 71004, Viljandi
sotsiaalteaduste valdkond
Faculty phone: 
(+372) 737 5957
Faculty address: 
Lossi 36, 51003, Tartu
  • haridusteaduste instituut
    Faculty phone: 
    (+372) 737 6440
    Faculty address: 
    Salme 1a, ruum 29, 50103, Tartu
  • Johan Skytte poliitikauuringute instituut
  • majandusteaduskond
    Faculty phone: 
    (+372) 737 6310
    Faculty address: 
    Narva mnt 4-A315, 51009, Tartu
  • psühholoogia instituut
    Faculty phone: 
    (+372) 737 5902
    Faculty address: 
    Näituse 2, 50409, Tartu
  • õigusteaduskond
    Faculty phone: 
    (+372) 737 5390
    Faculty address: 
    Näituse 20, 50409, Tartu
  • ühiskonnateaduste instituut
    Faculty phone: 
    (+372) 737 5188
    Faculty address: 
    Lossi 36, 51003, Tartu
  • Narva kolledž
    Faculty phone: 
    (+372) 740 1900
    Faculty address: 
    Raekoja plats 2, 20307, Narva
  • Pärnu kolledž
    Faculty phone: 
    (+372) 445 0520
    Faculty address: 
    Ringi 35, 80012, Pärnu
meditsiiniteaduste valdkond
Faculty phone: 
(+372) 737 5326
Faculty address: 
Ravila 19, 50411, Tartu
  • bio- ja siirdemeditsiini instituut
    Faculty phone: 
    +(372) 737 4210
    Faculty address: 
    Biomeedikum, Ravila 19, 50411, Tartu
  • farmaatsia instituut
    Faculty phone: 
    (+372) 737 5286
    Faculty address: 
    Nooruse 1, 50411, Tartu
  • hambaarstiteaduse instituut
    Faculty phone: 
    (+372) 731 9856
    Faculty address: 
    Raekoja plats 6, 51003, Tartu
  • kliinilise meditsiini instituut
    Faculty phone: 
    (+372) 737 5323
    Faculty address: 
    L. Puusepa 8, 51014, Tartu, Eesti
  • peremeditsiini ja rahvatervishoiu instituut
    Faculty phone: 
    +(372) 737 4190
    Faculty address: 
    Ravila 19, 50411 Tartu
  • sporditeaduste ja füsioteraapia instituut
    Faculty phone: 
    (+372) 737 5360
    Faculty address: 
    Jakobi 5-205, 51014, Tartu
loodus- ja täppisteaduste valdkond
Faculty phone: 
(+372) 737 5820
Faculty address: 
Vanemuise 46-208, 51014, Tartu
  • arvutiteaduse instituut
    Faculty phone: 
    (+372) 737 5445
    Faculty address: 
    J. Liivi 2, 50409, Tartu
  • Eesti mereinstituut
    Faculty phone: 
    (+372) 671 8902
    Faculty address: 
    Mäealuse 14, 12618, Tallinn
  • füüsika instituut
    Faculty address: 
    W. Ostwaldi tn 1, 50411, Tartu
  • keemia instituut
    Faculty phone: 
    (+372) 737 5261
    Faculty address: 
    Ravila 14a, 50411, Tartu
  • matemaatika ja statistika instituut
    Faculty phone: 
    (+372) 737 5860
    Faculty address: 
    J. Liivi 2, 50409, Tartu
  • molekulaar- ja rakubioloogia instituut
    Faculty phone: 
    (+372) 737 5011
    Faculty address: 
    Riia 23, 23b-134, 51010, Tartu
  • tehnoloogiainstituut
    Faculty phone: 
    (+372) 737 4800
    Faculty address: 
    Nooruse 1, 50411, Tartu
  • ökoloogia ja maateaduste instituut
    Faculty phone: 
    (+372) 737 5835
    Faculty address: 
    Vanemuise 46, 51014, Tartu
Asutused
Tugiüksused
  • infotehnoloogia osakond
    Faculty phone: 
    (+372) 737 6000, arvutiabi: 737 5500
    Faculty address: 
    Ülikooli 18a, 51014, Tartu
  • kantselei
    Faculty phone: 
    (+372) 737 5606
    Faculty address: 
    Ülikooli 18a, 51014, Tartu
  • kinnisvaraosakond
    Faculty phone: 
    (+372) 737 5137
    Faculty address: 
    Ülikooli 18a, 51014, Tartu
  • personaliosakond
    Faculty phone: 
    (+372) 737 5145
    Faculty address: 
    Ülikooli 18, ruumid 302 ja 304, 50090, Tartu
  • rahandusosakond
    Faculty phone: 
    (+372) 737 5125
    Faculty address: 
    Jakobi 4, 51014, Tartu
  • rektoraadi büroo
    Faculty phone: 
    (+372) 737 5600
    Faculty address: 
    Ülikooli 18, 51014, Tartu
  • siseauditi büroo
    Faculty address: 
    Ülikooli 17-114, 51014, Tartu
  • Tallinna esindus
    Faculty phone: 
    737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • teadus- ja arendusosakond
    Faculty phone: 
    (+372) 737 6192
    Faculty address: 
    Lossi 3, III korrus, 51003, Tartu
  • turundus- ja kommunikatsiooniosakond
    Faculty phone: 
    (+372) 737 5687
    Faculty address: 
    Ülikooli 18, ruum 210, 50090, Tartu
  • õppeosakond
    Faculty phone: 
    (+372) 737 6215
    Faculty address: 
    Ülikooli 18, 50090, Tartu
  • üliõpilasesindus
    Faculty phone: 
    (+372) 737 5400
    Faculty address: 
    Ülikooli 18b, 51014, Tartu
Muud üksused
  • MTÜ Tartu Ülikooli Akadeemiline Spordiklubi
    Faculty phone: 
    +372 737 5371
    Faculty address: 
    Ujula 4, 51008 Tartu
  • MTÜ Tartu Üliõpilasküla
    Faculty phone: 
    +372 740 9959
    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • MTÜ Tartu Üliõpilasmaja
    Faculty phone: 
    +372 730 2400
    Faculty address: 
    Kalevi 24, Tartu
  • OÜ Tartu Ülikooli Kirjastus
    Faculty phone: 
    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Sihtasutus Tartu Ülikooli Kliinikum
    Faculty phone: 
    +372 731 8111
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • Tartu Ülikooli Sihtasutus
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18a-106, Tartu

TÜ üksuste kontaktandmed

humanitaarteaduste ja kunstide valdkond
Faculty phone: 
(+372) 737 5341
Faculty address: 
Jakobi 2 - 116-121, 51014, Tartu
  • ajaloo ja arheoloogia instituut
    Faculty phone: 
    (+372) 737 5651
    Faculty address: 
    Jakobi 2, 51003, Tartu
  • eesti ja üldkeeleteaduse instituut
    Faculty phone: 
    (+372) 737 5221
    Faculty address: 
    Jakobi 2, IV korrus, 51014, Tartu
  • filosoofia ja semiootika instituut
    Faculty phone: 
    (+372) 737 5314
    Faculty address: 
    Jakobi 2, III korrus, ruumid 309-352, 51014, Tartu
  • kultuuriteaduste ja kunstide instituut
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003, Tartu
  • maailma keelte ja kultuuride kolledž
    Faculty address: 
    Lossi 3, 51003, Tartu
  • usuteaduskond
    Faculty phone: 
    (+372) 737 5300
    Faculty address: 
    Ülikooli 18-310, 50090, Tartu
  • Viljandi kultuuriakadeemia
    Faculty phone: 
    (+372) 435 5232
    Faculty address: 
    Posti 1, 71004, Viljandi
sotsiaalteaduste valdkond
Faculty phone: 
(+372) 737 5957
Faculty address: 
Lossi 36, 51003, Tartu
  • haridusteaduste instituut
    Faculty phone: 
    (+372) 737 6440
    Faculty address: 
    Salme 1a, ruum 29, 50103, Tartu
  • Johan Skytte poliitikauuringute instituut
  • majandusteaduskond
    Faculty phone: 
    (+372) 737 6310
    Faculty address: 
    Narva mnt 4-A315, 51009, Tartu
  • psühholoogia instituut
    Faculty phone: 
    (+372) 737 5902
    Faculty address: 
    Näituse 2, 50409, Tartu
  • õigusteaduskond
    Faculty phone: 
    (+372) 737 5390
    Faculty address: 
    Näituse 20, 50409, Tartu
  • ühiskonnateaduste instituut
    Faculty phone: 
    (+372) 737 5188
    Faculty address: 
    Lossi 36, 51003, Tartu
  • Narva kolledž
    Faculty phone: 
    (+372) 740 1900
    Faculty address: 
    Raekoja plats 2, 20307, Narva
  • Pärnu kolledž
    Faculty phone: 
    (+372) 445 0520
    Faculty address: 
    Ringi 35, 80012, Pärnu
meditsiiniteaduste valdkond
Faculty phone: 
(+372) 737 5326
Faculty address: 
Ravila 19, 50411, Tartu
  • bio- ja siirdemeditsiini instituut
    Faculty phone: 
    +(372) 737 4210
    Faculty address: 
    Biomeedikum, Ravila 19, 50411, Tartu
  • farmaatsia instituut
    Faculty phone: 
    (+372) 737 5286
    Faculty address: 
    Nooruse 1, 50411, Tartu
  • hambaarstiteaduse instituut
    Faculty phone: 
    (+372) 731 9856
    Faculty address: 
    Raekoja plats 6, 51003, Tartu
  • kliinilise meditsiini instituut
    Faculty phone: 
    (+372) 737 5323
    Faculty address: 
    L. Puusepa 8, 51014, Tartu, Eesti
  • peremeditsiini ja rahvatervishoiu instituut
    Faculty phone: 
    +(372) 737 4190
    Faculty address: 
    Ravila 19, 50411 Tartu
  • sporditeaduste ja füsioteraapia instituut
    Faculty phone: 
    (+372) 737 5360
    Faculty address: 
    Jakobi 5-205, 51014, Tartu
loodus- ja täppisteaduste valdkond
Faculty phone: 
(+372) 737 5820
Faculty address: 
Vanemuise 46-208, 51014, Tartu
  • arvutiteaduse instituut
    Faculty phone: 
    (+372) 737 5445
    Faculty address: 
    J. Liivi 2, 50409, Tartu
  • Eesti mereinstituut
    Faculty phone: 
    (+372) 671 8902
    Faculty address: 
    Mäealuse 14, 12618, Tallinn
  • füüsika instituut
    Faculty address: 
    W. Ostwaldi tn 1, 50411, Tartu
  • keemia instituut
    Faculty phone: 
    (+372) 737 5261
    Faculty address: 
    Ravila 14a, 50411, Tartu
  • matemaatika ja statistika instituut
    Faculty phone: 
    (+372) 737 5860
    Faculty address: 
    J. Liivi 2, 50409, Tartu
  • molekulaar- ja rakubioloogia instituut
    Faculty phone: 
    (+372) 737 5011
    Faculty address: 
    Riia 23, 23b-134, 51010, Tartu
  • tehnoloogiainstituut
    Faculty phone: 
    (+372) 737 4800
    Faculty address: 
    Nooruse 1, 50411, Tartu
  • ökoloogia ja maateaduste instituut
    Faculty phone: 
    (+372) 737 5835
    Faculty address: 
    Vanemuise 46, 51014, Tartu
Asutused
Tugiüksused
  • infotehnoloogia osakond
    Faculty phone: 
    (+372) 737 6000, arvutiabi: 737 5500
    Faculty address: 
    Ülikooli 18a, 51014, Tartu
  • kantselei
    Faculty phone: 
    (+372) 737 5606
    Faculty address: 
    Ülikooli 18a, 51014, Tartu
  • kinnisvaraosakond
    Faculty phone: 
    (+372) 737 5137
    Faculty address: 
    Ülikooli 18a, 51014, Tartu
  • personaliosakond
    Faculty phone: 
    (+372) 737 5145
    Faculty address: 
    Ülikooli 18, ruumid 302 ja 304, 50090, Tartu
  • rahandusosakond
    Faculty phone: 
    (+372) 737 5125
    Faculty address: 
    Jakobi 4, 51014, Tartu
  • rektoraadi büroo
    Faculty phone: 
    (+372) 737 5600
    Faculty address: 
    Ülikooli 18, 51014, Tartu
  • siseauditi büroo
    Faculty address: 
    Ülikooli 17-114, 51014, Tartu
  • Tallinna esindus
    Faculty phone: 
    737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • teadus- ja arendusosakond
    Faculty phone: 
    (+372) 737 6192
    Faculty address: 
    Lossi 3, III korrus, 51003, Tartu
  • turundus- ja kommunikatsiooniosakond
    Faculty phone: 
    (+372) 737 5687
    Faculty address: 
    Ülikooli 18, ruum 210, 50090, Tartu
  • õppeosakond
    Faculty phone: 
    (+372) 737 6215
    Faculty address: 
    Ülikooli 18, 50090, Tartu
  • üliõpilasesindus
    Faculty phone: 
    (+372) 737 5400
    Faculty address: 
    Ülikooli 18b, 51014, Tartu
Muud üksused
  • MTÜ Tartu Ülikooli Akadeemiline Spordiklubi
    Faculty phone: 
    +372 737 5371
    Faculty address: 
    Ujula 4, 51008 Tartu
  • MTÜ Tartu Üliõpilasküla
    Faculty phone: 
    +372 740 9959
    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • MTÜ Tartu Üliõpilasmaja
    Faculty phone: 
    +372 730 2400
    Faculty address: 
    Kalevi 24, Tartu
  • OÜ Tartu Ülikooli Kirjastus
    Faculty phone: 
    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Sihtasutus Tartu Ülikooli Kliinikum
    Faculty phone: 
    +372 731 8111
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • Tartu Ülikooli Sihtasutus
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18a-106, Tartu

Publikatsioonid 2002-2013

2013 (49)

  1. Okada Y et al.

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Nature. 2013 Dec 25. doi: 10.1038/nature12873. [Epub ahead of print] PubMed PMID: 24390342.

Co-authors (EGCUT) – Esko T, Metspalu A

  1. Vaher U et al.

De Novo SCN8A Mutation Identified by Whole-Exome Sequencing in a Boy With Neonatal Epileptic Encephalopathy, Multiple Congenital Anomalies, and Movement Disorders.

J Child Neurol. 2013 Dec 18. [Epub ahead of print] PubMed PMID: 24352161.

Co-authors (EGCUT) – Vaher U, Nõukas M, Nikopensius T, Kals M, Annilo T, Nelis M, Metspalu A

  1. Rodriguez-Fontenla C et al.

Assessment of osteoarthritis candidate genes in a meta-analysis of 9 genome-wide association studies.

Arthritis Rheum. 2013 Dec 10. doi: 10.1002/art.38300. [Epub ahead of print] PubMed PMID: 24338622.

Co-authors (EGCUT) – Esko T, Metspalu A

  1. Parsa A et al.

Common variants in mendelian kidney disease genes and their association with renal function.

J Am Soc Nephrol. 2013 Dec;24(12):2105-2117. doi: 10.1681/ASN.2012100983. Epub 2013 Sep 12. PubMed PMID: 24029420; PubMed Central PMCID: PMC3839542.

Co-authors (EGCUT) – Esko T, Mägi R, Metspalu A, Nikopensius T

  1. Yao C et al.

Sex- and age-interacting eQTLs in human complex diseases. Hum Mol Genet. 2013 Nov 28. [Epub ahead of print] PubMed PMID: 24242183.

Co-authors (EGCUT) – Esko T, Metspalu A

  1. Global Lipids Genetics Consortium et al.

Discovery and refinement of loci associated with lipid levels.

Nat Genet. 2013 Nov;45(11):1274-1283. doi: 10.1038/ng.2797. Epub 2013 Oct 6. PubMed PMID: 24097068; PubMed Central PMCID: PMC3838666.

Co-authors (EGCUT) – Esko T, Fischer K, Perola M, Metspalu A, Mihailov E

  1. Do R et al.

Common variants associated with plasma triglycerides and risk for coronary artery disease.

Nat Genet. 2013 Nov;45(11):1345-1352. doi: 10.1038/ng.2795. Epub 2013 Oct 6. PubMed PMID: 24097064.

Co-authors (EGCUT) – Esko T, Fischer K, Mihailov E, Perola M, Metspalu A

  1. Nikopensius T et al.

A missense mutation in DUSP6 is associated with Class III malocclusion.

J Dent Res. 2013 Oct;92(10):893-898. doi: 10.1177/0022034513502790. Epub 2013 Aug 21. PubMed PMID: 23965468.

Co-authors (EGCUT) – Nikopensius T, Annilo T, Kals M, Kivistik PA, Milani L, Metspalu A

  1. Tammiste A et al.

Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression.

J Psychopharmacol. 2013 Oct;27(10):915-920. doi: 10.1177/0269881113499829. Epub 2013 Aug 7. PubMed PMID: 23926243.

Co-authors (EGCUT) – Tammiste A, Ng PC, Metspalu A, Esko T, Fischer K, Pettai K, Võsa U, Tšernikova N

  1. Westra HJ et al.

Systematic identification of trans eQTLs as putative drivers of known disease associations.

Nat Genet. 2013 Oct;45(10):1238-1243. doi: 10.1038/ng.2756. Epub 2013 Sep 8. PubMed PMID: 24013639.

Co-authors (EGCUT) – Esko T, Reinmaa E, Fischer K, Nelis M, Milani L,Perola M, Metspalu A

  1. Evans DM et al.

Mining the human phenome using allelic scores that index biological intermediates.

PLoS Genet. 2013 Oct;9(10):e1003919. doi:10.1371/journal.pgen.1003919. Epub 2013 Oct 31. PubMed PMID: 24204319; PubMed Central PMCID: PMC3814299.

Co-authors (EGCUT) – GIANT Consortium: Esko T, Mägi R, Nelis M, Fischer K, Mihailov E, Perola M, Metspalu A (Snieder H, Morris AD)

  1. Thorgeirsson TE et al.

A common biological basis of obesity and nicotine addiction.

Transl Psychiatry. 2013 Oct 1;3:e308. doi:10.1038/tp.2013.81. PubMed PMID: 24084939; PubMed Central PMCID: PMC3818010.

Co-authors (EGCUT) – ENGAGE consortium: Esko T, Mägi R, Nelis M, Metspalu A

  1. Dymerska D et al.

Lynch syndrome mutations shared by the Baltic States and Poland.

Clin Genet. 2013 Sep 5. doi: 10.1111/cge.12251. [Epub ahead of print] PubMed PMID: 24032978.

Co-authors (EGCUT) – Metspalu A

  1. Evangelou E et al.

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

Ann Rheum Dis. 2013 Sep 4. doi:10.1136/annrheumdis-2012-203114. [Epub ahead of print] PubMed PMID: 23989986.

Co-authors (EGCUT) – Esko T, Milani L, Metspalu A

  1. Graff M et al.

Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.

Hum Mol Genet. 2013 Sep 1;22(17):3597-3607. doi: 10.1093/hmg/ddt205. Epub 2013 May 12. PubMed PMID: 23669352; PubMed Central PMCID: PMC3736869.

Co-authors (EGCUT) – Esko T, Nelis M, Nikopensius T, Metspalu A, Mägi R

  1. Ivanov M et al.

Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function.

Genome Biol. 2013 Aug 19;14(8):R83. [Epub ahead of print] PubMed PMID: 23958281.

Co-authors (EGCUT) – Kals M, Metspalu A, Milani L

  1. Cheng CY et al.

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.

Am J Hum Genet. 2013 Aug 8;93(2):264-277. doi: 10.1016/j.ajhg.2013.06.016. PubMed PMID: 24144296; PubMed Central PMCID: PMC3772747.

Co-authors (EGCUT) – Haller T, Metspalu A

  1. Hu YJ et al.

Meta-analysis of gene-level associations for rare variants based on single-variant statistics.

Am J Hum Genet. 2013 Aug 8;93(2):236-248. doi: 10.1016/j.ajhg.2013.06.011. Epub 2013 Jul 25. PubMed PMID: 23891470; PubMed Central PMCID: PMC3738834.

Co-authors (EGCUT) – GIANT Consortium: Esko T, Mägi R, Nelis M, Fischer K, Mihailov E, Perola M, Metspalu A (Snieder H, Morris AD)

  1. Fernández-Rhodes L et al.

Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.

Am J Epidemiol. 2013 Aug 1;178(3):451-460. doi: 10.1093/aje/kws473. Epub  2013 Apr 4. PubMed PMID: 23558354; PubMed Central PMCID: PMC3816344.

Co-authors (EGCUT) – Esko T, Mihailov E, Metspalu A

  1. Amin N et al.

Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions.

Eur J Hum Genet. 2013 Aug;21(8):876-882. doi: 10.1038/ejhg.2012.263. Epub 2012 Dec 5. PubMed PMID: 23211697; PubMed Central PMCID: PMC3722675.

Co-authors (EGCUT) – Metspalu A, Esko T

  1. Byrne EM et al.

A genome-wide association study of sleep habits and insomnia.

Am J Med Genet B Neuropsychiatr Genet. 2013 Jul;162B(5):439-451. doi: 10.1002/ajmg.b.32168. Epub 2013 May 31. PubMed PMID: 23728906.

Co-authors (EGCUT) – Esko T, Teder-Laving M, Metspalu A

  1. Evangelou E et al.

The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males.

Ann Rheum Dis. 2013 Jul;72(7):1264-1265. doi: 10.1136/annrheumdis-2012-203182. Epub 2013 Mar 16. PubMed PMID: 23505243; PubMed Central PMCID: PMC3686326.

Co-authors (EGCUT) – Esko T, Metspalu A

  1. Fears R et al.

The perspective from EASAC and FEAM on direct-to-consumer genetic testing for health-related purposes.

Eur J Hum Genet. 2013 Jul;21(7):703-707. doi: 10.1038/ejhg.2012.238. Epub 2012 Nov 21. Review. PubMed PMID: 23169492; PubMed Central PMCID: PMC3722941.

Co-authors (EGCUT) –

  1. Paul DS et al.

Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci.

Genome Res. 2013 Jul;23(7):1130-1141. doi: 10.1101/gr.155127.113. Epub 2013 Apr 9. PubMed PMID: 23570689; PubMed Central PMCID: PMC3698506.

Co-authors (EGCUT) –

  1. Cousminer DL et al.

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.

Hum Mol Genet. 2013 Jul 1;22(13):2735-2747. doi: 10.1093/hmg/ddt104. Epub 2013 Feb 27. PubMed PMID: 23449627; PubMed Central PMCID: PMC3674797.

Co-authors (EGCUT) – GIANT Consortium: Esko T, Mägi R, Nelis M, Fischer K, Mihailov E, Perola M, Metspalu A (Snieder H, Morris AD)

  1. Rietveld CA et al.

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.

Science. 2013 Jun 21;340(6139):1467-1471. doi: 10.1126/science.1235488. Epub 2013 May 30. PubMed PMID: 23722424; PubMed Central PMCID: PMC3751588.

Co-authors (EGCUT) – Esko T, Milani L, Fischer K, Reinmaa E, Perola M, Metspalu A

  1. Võsa U et al.

Meta-analysis of microRNA expression in lung cancer.

Int J Cancer. 2013 Jun 15;132(12):2884-2893.doi: 10.1002/ijc.27981. Epub 2012 Dec 27. PubMed PMID: 23225545.

Co-authors (EGCUT) – Võsa U, Metspalu A, Annilo T

  1. Esko T et al.

Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity.

Eur J Hum Genet. 2013 Jun;21(6):659-665. doi: 10.1038/ejhg.2012.229. Epub 2012 Dec 19. PubMed PMID: 23249956; PubMed Central PMCID: PMC3658181.

Co-authors (EGCUT) – Esko T, Nelis M, Metspalu A

  1. Nikopensius T et al.

Non-syndromic tooth agenesis associated with a nonsense mutation in ectodysplasin-A (EDA).

J Dent Res. 2013 Jun;92(6):507-511. doi: 10.1177/0022034513487210. Epub 2013 Apr 19. PubMed PMID: 23603338.

Co-authors (EGCUT) – Annilo T, Kals M, Mägi R, Metspalu A

  1. den Hoed M et al.

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

Nat Genet. 2013 Jun;45(6):621-631. doi: 10.1038/ng.2610. Epub 2013 Apr 14. PubMed PMID: 23583979; PubMed Central PMCID: PMC3696959.

Co-authors (EGCUT) – Esko T, Mihailov E, Fischer K, Milani L, Metspalu A, Perola M

  1. Randall JC et al.

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.

PLoS Genet. 2013 Jun;9(6):e1003500. doi: 10.1371/journal.pgen.1003500. Epub 2013 Jun 6. PubMed PMID: 23754948; PubMed Central PMCID: PMC3674993.

Co-authors (EGCUT) – Esko T, Mägi R, Nelis M, Metspalu A, Perola M, Fischer K

  1. Berndt SI et al.

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

Nat Genet. 2013 May;45(5):501-512. doi: 10.1038/ng.2606. Epub 2013 Apr 7. PubMed PMID: 23563607.

Co-authors (EGCUT) – Mägi R, Mihailov E, Milani L, Metspalu A, Morris AD, Snieder H, Esko T, Fischer K

  1. Lener MR et al.

Can selenium levels act as a marker of colorectal cancer risk?

BMC Cancer. 2013 Apr 29;13:214. doi:10.1186/1471-2407-13-214. PubMed PMID: 23627542; PubMed Central PMCID:PMC3641950.

Co-authors (EGCUT) – Tammesoo ML, Metspalu A

  1. Perry JR et al.

A genome-wide association study of early menopause and the combined impact of identified variants.

Hum Mol Genet. 2013 Apr 1;22(7):1465-1472. doi: 10.1093/hmg/dds551. Epub 2013 Jan 9. PubMed PMID: 23307926; PubMed Central PMCID: PMC3596848.

Co-authors (EGCUT) – Esko T, Metspalu A

  1. Codd V et al.

Identification of seven loci affecting mean telomere length and their association with disease.

Nat Genet. 2013 Apr;45(4):422-427, 427e1-2. doi: 10.1038/ng.2528. PubMed PMID: 23535734.

Co-authors (EGCUT) – Fischer K, Esko T, Mihailov E, Metspalu A, Perola M

  1. Ivanov M et al.

In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes.

Nucleic Acids Res. 2013 Apr 1;41(6):e72. doi:10.1093/nar/gks1467. Epub 2013 Jan 15. PubMed PMID: 23325842; PubMed Central PMCID: PMC3616706.

Co-authors (EGCUT) – Kals M, Milani L

  1. Verhoeven V et al.

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.

Nat Genet. 2013 Mar;45(3):314-318. doi: 10.1038/ng.2554. Epub 2013 Feb 10. Erratum in: Nat Genet. 2013 Jun;45(2):712. Janmahasathian, Sarayut [corrected to Sarayut Janmahasatian]. PubMed PMID: 23396134; PubMed Central PMCID: PMC3740568.

Co-authors (EGCUT) – Haller T, Metspalu A

  1. Köttgen A et al.

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Nat Genet. 2013 Feb;45(2):145-154. doi: 10.1038/ng.2500. Epub 2012 Dec 23. PubMed PMID: 23263486; PubMed Central PMCID: PMC3663712.

Co-authors (EGCUT) – Esko T, Org E, Metspalu A, Snieder H, Haller T

  1. Allebrandt KV et al.

A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila.

Mol Psychiatry. 2013 Jan;18(1):122-132. doi: 10.1038/mp.2011.142. Epub 2011 Nov 22. PubMed PMID: 22105623.

Co-authors (EGCUT) – Esko T, Teder-Laving M, Metspalu A

  1. CARDIoGRAMplusC4D Consortium et al.

Large-scale association analysis identifies new risk loci for coronary artery disease.

Nat Genet. 2013 Jan;45(1):25-33. doi: 10.1038/ng.2480. Epub 2012 Dec 2. PubMed PMID: 23202125; PubMed Central PMCID: PMC3679547.

Co-authors (EGCUT) – Esko T, Fischer K, Mihailov E, Maouche S, Morris AD, Metspalu A, Perola M, Milani L

  1. Kumar V et al.

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.

PLoS Genet. 2013;9(1):e1003201. doi: 10.1371/journal.pgen.1003201. Epub 2013 Jan 17. PubMed PMID: 23341781; PubMed Central PMCID: PMC3547830.

Co-authors (EGCUT) – Esko T, Reinmaa E, Võsa U, Metspalu A

  1. Fall T et al.

European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium. The role of adiposity in cardiometabolic traits: a mendelian randomization analysis. PLoS Med. 2013;10(6):e1001474. doi: 10.1371/journal.pmed.1001474. Epub 2013 Jun 25. PubMed  PMID: 23824655; PubMed Central PMCID: PMC3692470.

Co-authors (EGCUT) – Mägi R, Fischer K, Kals M, Esko T, Metspalu A

  1. Pichler I et al.

Serum iron levels and the risk of Parkinson disease: a mendelian randomization study.

PLoS Med. 2013;10(6):e1001462. doi: 10.1371/journal.pmed.1001462. Epub 2013 Jun 4. Erratum in: PLoS Med. 2013 Jun;10(6). doi:10.1371/annotation/c4d81646-0c0e-4a3e-9425-b220bae2d8b6. PubMed PMID: 23750121; PubMed Central PMCID: PMC3672214.

Co-authors (EGCUT) – Esko T, Metspalu A

  1. Vimaleswaran KS et al.

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.

PloS Med. 2013;10(2):e1001383. doi: 10.1371/journal.pmed.1001383. Epub 2013 Feb 5. PubMed PMID: 23393431; PubMed Central PMCID: PMC3564800.

Co-authors (EGCUT) – Mägi R, Esko T, Metspalu A

  1. Walters RG et al.

Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity.

PLoS One. 2013;8(3):e58048. doi: 10.1371/journal.pone.0058048. Epub 2013 Mar 12. PubMed PMID: 23554873; PubMed Central PMCID: PMC3595275.

Co-authors (EGCUT) – Esko T, Metspalu A

  1. Khrunin AV et al.

A genome-wide analysis of populations from European Russia reveals a new pole of genetic diversity in northern Europe.

PLoS One. 2013;8(3):e58552. doi: 10.1371/journal.pone.0058552. Epub 2013 Mar 7. PubMed PMID: 23505534; PubMed Central PMCID: PMC3591355.

Co-authors (EGCUT) – Esko T, Nelis M, Metspalu A

  1. Mägi R et al.

Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery.

PLoS One. 2013 Aug 7;8(8):e70735. doi: 10.1371/journal.pone.0070735. eCollection 2013. PubMed PMID: 23950990.

Co-authors (EGCUT) –

  1. Haller T et al.

RegScan: a GWAS tool for quick estimation of allele effects on continuous traits and their combinations. Brief Bioinform. 2013 Sep 5. [Epub ahead of print] PubMed PMID: 24008273.

Co-authors (EGCUT) – Mägi R, Kals M, Esko T, Fischer K

  1. Migliano A et al.

Evolution of the pygmy phenotype: evidence of positive selection from genome-wide scans in African, Asian and Melanesian pygmies. Hum Biol. 2013 Feb-Jun;85(1-3):251-284. PubMed PMID: 24297229.

Co-authors (EGCUT) – Mägi R, Nelis M

 

2012 (41)

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.
Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O''Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O''Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa MF, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Lambert JC, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Coassin S, Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; WTCCC2, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Meisinger C, Gieger C, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Stengel B, Ruggiero D, Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki IB, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman J, Hayward C, Ridker PM, Parsa A, Bochud M, Heid IM, Kao WH, Fox CS, Köttgen A.
Avaldatud: Human Molecular Genetics. 2012 Dec 15;21(24):5329-43.
DOI: 10.1093/hmg/dds369


A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, Jackson AU, Johnson T, Kanoni S, Ladenvall C, Lagou V, Lahti J, Lecoeur C, Liu Y, Martinez-Larrad MT, Montasser ME, Navarro P, Perry JR, Rasmussen-Torvik LJ, Salo P, Sattar N, Shungin D, Strawbridge RJ, Tanaka T, van Duijn CM, An P, de Andrade M, Andrews JS, Aspelund T, Atalay M, Aulchenko Y, Balkau B, Bandinelli S, Beckmann JS, Beilby JP, Bellis C, Bergman RN, Blangero J, Boban M, Boehnke M, Boerwinkle E, Bonnycastle LL, Boomsma DI, Borecki IB, Böttcher Y, Bouchard C, Brunner E, Budimir D, Campbell H, Carlson O, Chines PS, Clarke R, Collins FS, Corbatón-Anchuelo A, Couper D, de Faire U, Dedoussis GV, Deloukas P, Dimitriou M, Egan JM, Eiriksdottir G, Erdos MR, Eriksson JG, Eury E, Ferrucci L, Ford I, Forouhi NG, Fox CS, Franzosi MG, Franks PW, Frayling TM, Froguel P, Galan P, de Geus E, Gigante B, Glazer NL, Goel A, Groop L, Gudnason V, Hallmans G, Hamsten A, Hansson O, Harris TB, Hayward C, Heath S, Hercberg S, Hicks AA, Hingorani A, Hofman A, Hui J, Hung J, Jarvelin MR, Jhun MA, Johnson PC, Jukema JW, Jula A, Kao WH, Kaprio J, Kardia SL, Keinanen-Kiukaanniemi S, Kivimaki M, Kolcic I, Kovacs P, Kumari M, Kuusisto J, Kyvik KO, Laakso M, Lakka T, Lannfelt L, Lathrop GM, Launer LJ, Leander K, Li G, Lind L, Lindstrom J, Lobbens S, Loos RJ, Luan J, Lyssenko V, Mägi R, Magnusson PK, Marmot M, Meneton P, Mohlke KL, Mooser V, Morken MA, Miljkovic I, Narisu N, O''Connell J, Ong KK, Oostra BA, Palmer LJ, Palotie A, Pankow JS, Peden JF, Pedersen NL, Pehlic M, Peltonen L, Penninx B, Pericic M, Perola M, Perusse L, Peyser PA, Polasek O, Pramstaller PP, Province MA, Räikkönen K, Rauramaa R, Rehnberg E, Rice K, Rotter JI, Rudan I, Ruokonen A, Saaristo T, Sabater-Lleal M, Salomaa V, Savage DB, Saxena R, Schwarz P, Seedorf U, Sennblad B, Serrano-Rios M, Shuldiner AR, Sijbrands EJ, Siscovick DS, Smit JH, Small KS, Smith NL, Smith AV, Stančáková A, Stirrups K, Stumvoll M, Sun YV, Swift AJ, Tönjes A, Tuomilehto J, Trompet S, Uitterlinden AG, Uusitupa M, Vikström M, Vitart V, Vohl MC, Voight BF, Vollenweider P, Waeber G, Waterworth DM, Watkins H, Wheeler E, Widen E, Wild SH, Willems SM, Willemsen G, Wilson JF, Witteman JC, Wright AF, Yaghootkar H, Zelenika D, Zemunik T, Zgaga L; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium; Multiple Tissue Human Expression Resource (MUTHER) Consortium, Wareham NJ, McCarthy MI, Barroso I, Watanabe RM, Florez JC, Dupuis J, Meigs JB, Langenberg C.
Avaldatud: Nat Genet. 2012 May 13;44(6):659-69
DOI: 10.1038/ng.2274


Genome-Wide Association Analysis of Imputed Rare Variants: Application to Seven Common Complex Diseases
Mägi R, Asimit JL, Day-Williams AG, Zeggini E, Morris AP.
Avaldatud: Genet Epidemiol. 2012 Sep 5
DOI: 10.1002/gepi.21675


A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site.
Nürnberg ST, Rendon A, Smethurst PA, Paul DS, Voss K, Thon JN, Lloyd-Jones H, Sambrook JG, Tijssen MR; HaemGen Consortium, Italiano JE Jr, Deloukas P, Gottgens B, Soranzo N, Ouwehand WH.
Avaldatud: Blood. 2012 Dec 6;120(24):4859-68.
DOI: doi: 10.1182/blood-2012-01-401893


The perspective from EASAC and FEAM on direct-to-consumer genetic testing for health-related purposes
Robin Fears*, Volker ter Meulen and for the EASAC–FEAM Working Group (Participants in the Working Group were: Stefania Boccia, Martina Cornel, Marc Delpech, Anne De Paepe, Xavier Estivill, Mats Hansson, Katia Karalis, Andres Metspalu, Markus Nöthen, Peter Propping, Jorge Sequeiros, Ron Zimmern, Volker ter Meulen (Chair), Robin Fears (secretariat).
Avaldatud: European Journal of Human Genetics (2012), 1–5
DOI: doi:10.1038/ejhg.2012.238


A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila
Allebrandt KV, Amin N, Müller-Myhsok B, Esko T, Teder-Laving M, Azevedo RV, Hayward C, van Mill J, Vogelzangs N, Green EW, Melville SA, Lichtner P, Wichmann HE, Oostra BA, Janssens AC, Campbell H, Wilson JF, Hicks AA, Pramstaller PP, Dogas Z, Rudan I, Merrow M, Penninx B, Kyriacou CP, Metspalu A, van Duijn CM, Meitinger T, Roenneberg T.
Avaldatud: Mol Psychiatry. Nov 22.
DOI: 10.1038/mp.2011.142


Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.
Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O''Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O''Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa MF, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Lambert JC, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Coassin S, Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; WTCCC2, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Meisinger C, Gieger C, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Stengel B, Ruggiero D, Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki IB, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman J, Hayward C, Ridker PM, Parsa A, Bochud M, Heid IM, Kao WH, Fox CS, Köttgen A.
Avaldatud: Hum Mol Genet 2012; 21(24): 5329-5343


Meta-analysis of microrna expression in lung cancer
Võsa U, Vooder T, Kolde R, Vilo J, Metspalu A, Annilo T.
Avaldatud: International Journal of Cancer. Published online: 27 DEC 2012
DOI: doi:10.1002/ijc.27981


Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions
Amin N, Hottenga JJ, Hansell NK, Janssens AC, de Moor MH, Madden PA, Zorkoltseva IV, Penninx BW, Terracciano A, Uda M, Tanaka T, Esko T, Realo A, Ferrucci L, Luciano M, Davies G, Metspalu A, Abecasis GR, Deary IJ, Raikkonen K, Bierut LJ, Costa PT, Saviouk V, Zhu G, Kirichenko AV, Isaacs A, Aulchenko YS, Willemsen G, Heath AC, Pergadia ML, Medland SE, Axenovich TI, de Geus E, Montgomery GW, Wright MJ, Oostra BA, Martin NG, Boomsma DI, van Duijn CM.
Avaldatud: European Journal of Human Genetics
DOI: 10.1038/ejhg.2012.263.


Large-scale association analysis identifies new risk loci for coronary artery disease
The CARDIoGRAMplusC4D Consortium, Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T, Folkersen L, Goel A, Grundberg E, Havulinna AS, Ho WK, Hopewell JC, Eriksson N, Kleber ME, Kristiansson K, Lundmark P, Lyytikäinen LP, Rafelt S, Shungin D, Strawbridge RJ, Thorleifsson G, Tikkanen E, Van Zuydam N, Voight BF, Waite LL, Zhang W, Ziegler A, Absher D, Altshuler D, Balmforth AJ, Barroso I, Braund PS, Burgdorf C, Claudi-Boehm S, Cox D, Dimitriou M, Do R; DIAGRAM Consortium; CARDIOGENICS Consortium, Doney AS, Mokhtari NE, Eriksson P, Fischer K, Fontanillas P, Franco-Cereceda A, Gigante B, Groop L, Gustafsson S, Hager J, Hallmans G, Han BG, Hunt SE, Kang HM, Illig T, Kessler T, Knowles JW, Kolovou G, Kuusisto J, Langenberg C, Langford C, Leander K, Lokki ML, Lundmark A, McCarthy MI, Meisinger C, Melander O, Mihailov E, Maouche S, Morris AD, Müller-Nurasyid M; MuTHER Consortium, Nikus K, Peden JF, Rayner NW, Rasheed A, Rosinger S, Rubin D, Rumpf MP, Schäfer A, Sivananthan M, Song C, Stewart AF, Tan ST, Thorgeirsson G, Schoot CE, Wagner PJ; Wellcome Trust Case Control Consortium, Wells GA, Wild PS, Yang TP, Amouyel P, Arveiler D, Basart H, Boehnke M, Boerwinkle E, Brambilla P, Cambien F, Cupples AL, de Faire U, Dehghan A, Diemert P, Epstein SE, Evans A, Ferrario MM, Ferrières J, Gauguier D, Go AS, Goodall AH, Gudnason V, Hazen SL, Holm H, Iribarren C, Jang Y, Kähönen M, Kee F, Kim HS, Klopp N, Koenig W, Kratzer W, Kuulasmaa K, Laakso M, Laaksonen R, Lee JY, Lind L, Ouwehand WH, Parish S, Park JE, Pedersen NL, Peters A, Quertermous T, Rader DJ, Salomaa V, Schadt E, Shah SH, Sinisalo J, Stark K, Stefansson K, Trégouët DA, Virtamo J, Wallentin L, Wareham N, Zimmermann ME, Nieminen MS, Hengstenberg C, Sandhu MS, Pastinen T, Syvänen AC, Hovingh GK, Dedoussis G, Franks PW, Lehtimäki T, Metspalu A, Zalloua PA, Siegbahn A, Schreiber S, Ripatti S, Blankenberg SS, Perola M, Clarke R, Boehm BO, O''''''''Donnell C, Reilly MP, März W, Collins R, Kathiresan S, Hamsten A, Kooner JS, Thorsteinsdottir U, Danesh J, Palmer CN, Roberts R, Watkins H, Schunkert H, Samani NJ.
Avaldatud: Nature Genetics Dec 2.
DOI: 10.1038/ng.2480.


DNA methylation dynamics in the hepatic CYP3A4 gene promoter
Kacevska M, Ivanov M, Wyss A, Kasela S, Milani L, Rane A, Ingelman-Sundberg M.
Avaldatud: Biochimie. 2012 Nov; 94(11):2338-44.
DOI: 10.1016/j.biochi.2012.07.013.


Genetic effects on variability: FTO genotype is associated with phenotypic variance of body mass index
Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, Waite L, Smith AV, Yerges-Armstrong LM, Monda KL, Hadley D, Mahajan A, Li G, Kapur K, Vitart V, Huffman JE, Wang SR, Palmer C, Esko T, Fischer K, Zhao JH, Demirkan A, Isaacs A, Feitosa MF, Luan J, Heard-Costa NL, White C, Jackson AU, Preuss M, Ziegler A, Eriksson J, Kutalik Z, Frau F, Nolte IM, Van Vliet-Ostaptchouk JV, Hottenga JJ, Jacobs KB, Verweij N, Goel A, Medina-Gomez C, Estrada K, Bragg-Gresham JL, Sanna S, Sidore C, Tyrer J, Teumer A, Prokopenko I, Mangino M, Lindgren CM, Assimes TL, Shuldiner AR, Hui J, Beilby JP, McArdle WL, Hall P, Haritunians T, Zgaga L, Kolcic I, Polasek O, Zemunik T, Oostra BA, Junttila MJ, Grönberg H, Schreiber S, Peters A, Hicks AA, Stephens J, Foad NS, Laitinen J, Pouta A, Kaakinen M, Willemsen G, Vink JM, Wild SH, Navis G, Asselbergs FW, Homuth G, John U, Iribarren C, Harris T, Launer L, Gudnason V, O''''Connell JR, Boerwinkle E, Cadby G, Palmer LJ, James AL, Musk AW, Ingelsson E, Psaty BM, Beckmann JS, Waeber G, Vollenweider P, Hayward C, Wright AF, Rudan I, Groop LC, Metspalu A, Tee Khaw K, van Duijn CM, Borecki IB, Province MA, Wareham NJ, Tardif JC, Huikuri HV, Cupples LA, Atwood LD, Fox CS, Boehnke M, Collins FS, Mohlke KL, Erdmann J, Schunkert H, Hengstenberg C, Stark K, Lorentzon M, Ohlsson C, Cusi D, Staessen JA, Van der Klauw MM, Pramstaller PP, Kathiresan S, Jolley JD, Ripatti S, Jarvelin MR, de Geus EJ, Boomsma DI, Penninx B, Wilson JF, Campbell H, Chanock SJ, van der Harst P, Hamsten A, Watkins H, Hofman A, Witteman JC, Zillikens MC, Uitterlinden AG, Rivadeneira F, Zillikens MC, Kiemeney LA, Vermeulen SH, Abecasis GR, Schlessinger D, Schipf S, Stumvoll M, Tönjes A, Spector TD, North KE, Lettre G, McCarthy MI, Berndt SI, Heath AC, Madden PA, Nyholt DR, Montgomery GW, Martin NG, McKnight B, Strachan DP, Hill WG, Snieder H, Ridker PM, Thorsteinsdottir U, Stefansson K, Frayling TM, Hirschhorn JN, Goddard ME, Visscher PM.
Avaldatud: Nature, Vol: 490 (7419) pp: 267-72; Published: 2012-Oct-11
DOI: 10.1038/nature11401


History of the Diagnosis of a Sexually Transmitted Disease is Linked to Normal Variation in Personality Traits.
Mõttus R, Realo A, Allik J, Esko T, Metspalu A.
Avaldatud: The Journal of Sexual Medicine; Volume 9, Issue 11, Pages 2733–2981
DOI: 10.1111/j.1743-6109.2012.02891.x.


Influence of Common Genetic Variation on Lung Cancer Risk: Meta-Analysis of 14,900 Cases and 29,485 Controls.
Timofeeva MN, Hung RJ, Rafnar T, Christiani DC, Field JK, Bickeboller H, Risch A, McKay JD, Wang Y, Dai J, Gaborieau V, McLaughlin J, Brenner D, Narod S, Caporaso NE, Albanes D, Thun M, Eisen T, Wichmann HE, Rosenberger A, Han Y, Chen W, Zhu D, Spitz M, Wu X, Pande M, Zhao Y, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Gabrielsen ME, Skorpen F, Vatten L, Njølstad I, Chen C, Goodman G, Lathrop M, Benhamou S, Vooder T, Välk K, Nelis M, Metspalu A, Raji O, Chen Y, Gosney J, Liloglou T, Muley T, Dienemann H, Thorleifsson G, Shen H, Stefansson K, Brennan P, Amos CI, Houlston R, Landi MT; for TRICL Research Team.
Avaldatud: Human Molecular Genetics. Volume: 21 Issue: 22 Pages: 4980-95
DOI: 10.1093/hmg/dds334


A common variant near the KCNJ2 gene is associated with T-peak to T-end interval.
Marjamaa A, Oikarinen L, Porthan K, Ripatti S, Peloso G, Noseworthy PA, Viitasalo M, Nieminen MS, Toivonen L, Kontula K, Peltonen L, Havulinna AS, Jula A, O''Donnell CJ, Newton-Cheh C, Perola M, Salomaa V.
Avaldatud: Heart Rhythm. 2012 Jul;9 (7):1099-103. Epub 2012 Feb 15.
DOI: 10.1016/j.hrthm.2012.02.019


Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PC, Jukema JW, Johnson T, Mahajan A, Verweij N, Thorleifsson G, Hottenga JJ, Shah S, Smith AV, Sennblad B, Gieger C, Salo P, Perola M, Timpson NJ, Evans DM, Pourcain BS, Wu Y, Andrews JS, Hui J, Bielak LF, Zhao W, Horikoshi M, Navarro P, Isaacs A, O''''Connell JR, Stirrups K, Vitart V, Hayward C, Esko T, Mihailov E, Fraser RM, Fall T, Voight BF, Raychaudhuri S, Chen H, Lindgren CM, Morris AP, Rayner NW, Robertson N, Rybin D, Liu CT, Beckmann JS, Willems SM, Chines PS, Jackson AU, Kang HM, Stringham HM, Song K, Tanaka T, Peden JF, Goel A, Hicks AA, An P, Müller-Nurasyid M, Franco-Cereceda A, Folkersen L, Marullo L, Jansen H, Oldehinkel AJ, Bruinenberg M, Pankow JS, North KE, Forouhi NG, Loos RJ, Edkins S, Varga TV, Hallmans G, Oksa H, Antonella M, Nagaraja R, Trompet S, Ford I, Bakker SJ, Kong A, Kumari M, Gigante B, Herder C, Munroe PB, Caulfield M, Antti J, Mangino M, Small K, Miljkovic I, Liu Y, Atalay M, Kiess W, James AL, Rivadeneira F, Uitterlinden AG, Palmer CN, Doney AS, Willemsen G, Smit JH, Campbell S, Polasek O, Bonnycastle LL, Hercberg S, Dimitriou M, Bolton JL, Fowkes GR, Kovacs P, Lindström J, Zemunik T, Bandinelli S, Wild SH, Basart HV, Rathmann W, Grallert H; DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Maerz W, Kleber ME, Boehm BO, Peters A, Pramstaller PP, Province MA, Borecki IB, Hastie ND, Rudan I, Campbell H, Watkins H, Farrall M, Stumvoll M, Ferrucci L, Waterworth DM, Bergman RN, Collins FS, Tuomilehto J, Watanabe RM, de Geus EJ, Penninx BW, Hofman A, Oostra BA, Psaty BM, Vollenweider P, Wilson JF, Wright AF, Hovingh GK, Metspalu A, Uusitupa M, Magnusson PK, Kyvik KO, Kaprio J, Price JF, Dedoussis GV, Deloukas P, Meneton P, Lind L, Boehnke M, Shuldiner AR, van Duijn CM, Morris AD, Toenjes A, Peyser PA, Beilby JP, Körner A, Kuusisto J, Laakso M, Bornstein SR, Schwarz PE, Lakka TA, Rauramaa R, Adair LS, Smith GD, Spector TD, Illig T, de Faire U, Hamsten A, Gudnason V, Kivimaki M, Hingorani A, Keinanen-Kiukaanniemi SM, Saaristo TE, Boomsma DI, Stefansson K, van der Harst P, Dupuis J, Pedersen NL, Sattar N, Harris TB, Cucca F, Ripatti S, Salomaa V, Mohlke KL, Balkau B, Froguel P, Pouta A, Jarvelin MR, Wareham NJ, Bouatia-Naji N, McCarthy MI, Franks PW, Meigs JB, Teslovich TM, Florez JC, Langenberg C, Ingelsson E, Prokopenko I, Barroso I.
Avaldatud: Nature Genetics 2012 Sep; 44(9):991-1005. Epub 2012 Aug 12.
DOI: 10.1038/ng.2385


Methylation markers of early-stage non-small cell lung cancer
Lokk K, Vooder T, Kolde R, Välk K, Võsa U, Roosipuu R, Milani L, Fischer K, Koltsina M, Urgard E, Annilo T, Metspalu A, Tõnisson N.
Avaldatud: PLos One 2012;7(6):e39813. Epub 2012 Jun 29.
DOI: 10.1371/journal.pone.0039813


Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J, Lindgren CM, Müller-Nurasyid M, Pechlivanis S, Rayner NW, Scott LJ, Wiltshire S, Yengo L, Kinnunen L, Rossin EJ, Raychaudhuri S, Johnson AD, Dimas AS, Loos RJ, Vedantam S, Chen H, Florez JC, Fox C, Liu CT, Rybin D, Couper DJ, Kao WH, Li M, Cornelis MC, Kraft P, Sun Q, van Dam RM, Stringham HM, Chines PS, Fischer K, Fontanillas P, Holmen OL, Hunt SE, Jackson AU, Kong A, Lawrence R, Meyer J, Perry JR, Platou CG, Potter S, Rehnberg E, Robertson N, Sivapalaratnam S, Stančáková A, Stirrups K, Thorleifsson G, Tikkanen E, Wood AR, Almgren P, Atalay M, Benediktsson R, Bonnycastle LL, Burtt N, Carey J, Charpentier G, Crenshaw AT, Doney AS, Dorkhan M, Edkins S, Emilsson V, Eury E, Forsen T, Gertow K, Gigante B, Grant GB, Groves CJ, Guiducci C, Herder C, Hreidarsson AB, Hui J, James A, Jonsson A, Rathmann W, Klopp N, Kravic J, Krjutškov K, Langford C, Leander K, Lindholm E, Lobbens S, Männistö S, Mirza G, Mühleisen TW, Musk B, Parkin M, Rallidis L, Saramies J, Sennblad B, Shah S, Sigurðsson G, Silveira A, Steinbach G, Thorand B, Trakalo J, Veglia F, Wennauer R, Winckler W, Zabaneh D, Campbell H, van Duijn C, Uitterlinden AG, Hofman A, Sijbrands E, Abecasis GR, Owen KR, Zeggini E, Trip MD, Forouhi NG, Syvänen AC, Eriksson JG, Peltonen L, Nöthen MM, Balkau B, Palmer CN, Lyssenko V, Tuomi T, Isomaa B, Hunter DJ, Qi L; Wellcome Trust Case Control Consortium; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Asian Genetic Epidemiology Network–Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium, Shuldiner AR, Roden M, Barroso I, Wilsgaard T, Beilby J, Hovingh K, Price JF, Wilson JF, Rauramaa R, Lakka TA, Lind L, Dedoussis G, Njølstad I, Pedersen NL, Khaw KT, Wareham NJ, Keinanen-Kiukaanniemi SM, Saaristo TE, Korpi-Hyövälti E, Saltevo J, Laakso M, Kuusisto J, Metspalu A, Collins FS, Mohlke KL, Bergman RN, Tuomilehto J, Boehm BO, Gieger C, Hveem K, Cauchi S, Froguel P, Baldassarre D, Tremoli E, Humphries SE, Saleheen D, Danesh J, Ingelsson E, Ripatti S, Salomaa V, Erbel R, Jöckel KH, Moebus S, Peters A, Illig T, de Faire U, Hamsten A, Morris AD, Donnelly PJ, Frayling TM, Hattersley AT, Boerwinkle E, Melander O, Kathiresan S, Nilsson PM, Deloukas P, Thorsteinsdottir U, Groop LC, Stefansson K, Hu F, Pankow JS, Dupuis J, Meigs JB, Altshuler D, Boehnke M, McCarthy MI.
Avaldatud: Nature Genetics. 2012 Sep;44(9):981-90. Epub 2012 Aug 12.
DOI: 10.1038/ng.2383


Results from a blind and a non-blind randomised trial run in parallel: experience from the Estonian Postmenopausal Hormone Therapy (EPHT) Trial
Veerus P, Fischer K, Hakama M, Hemminki E; EPHT Trial
Avaldatud: BMC Medical Research Methodology. 2012 Apr 4;12:44.


Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium
Kazma R, Babron MC, Gaborieau V, Génin E, Brennan P, Hung RJ, McLaughlin JR, Krokan HE, Elvestad MB, Skorpen F, Anderssen E, Vooder T, Välk K, Metspalu A, Field JK, Lathrop M, Sarasin A, Benhamou S; ILCCO consortium.
Avaldatud: Carcinogenesis. 2012 May;33(5):1059-64. Epub 2012 Mar 1.
DOI: 10.1093/carcin/bgs116.


Genome-wide Meta-analysis of Common Variant Differences between Men and Women
Boraska V, Jeroncic A, Colonna V, Southam L, Nyholt DR, William Rayner N, Perry JR, Toniolo D, Albrecht E, Ang W, Bandinelli S, Barbalic M, Barroso I, Beckmann JS, Biffar R, Boomsma D, Campbell H, Corre T, Erdmann J, Esko T, Fischer K, Franceschini N, Frayling TM, Girotto G, Gonzalez JR, Harris TB, Heath AC, Heid IM, Hoffmann W, Hofman A, Horikoshi M, Hua Zhao J, Jackson AU, Hottenga JJ, Jula A, Kähönen M, Khaw KT, Kiemeney LA, Klopp N, Kutalik Z, Lagou V, Launer LJ, Lehtimäki T, Lemire M, Lokki ML, Loley C, Luan J, Mangino M, Mateo Leach I, Medland SE, Mihailov E, Montgomery GW, Navis G, Newnham J, Nieminen MS, Palotie A, Panoutsopoulou K, Peters A, Pirastu N, Polasek O, Rehnström K, Ripatti S, Ritchie GR, Rivadeneira F, Robino A, Samani NJ, Shin SY, Sinisalo J, Smit JH, Soranzo N, Stolk L, Swinkels DW, Tanaka T, Teumer A, Tönjes A, Traglia M, Tuomilehto J, Valsesia A, van Gilst WH, van Meurs JB, Smith AV, Viikari J, Vink JM, Waeber G, Warrington NM, Widen E, Willemsen G, Wright AF, Zanke BW, Zgaga L; Wellcome Trust Case Control Consortium (WTCCC), Boehnke M, d''''Adamo AP, de Geus E, Demerath EW, den Heijer M, Eriksson JG, Ferrucci L, Gieger C, Gudnason V, Hayward C, Hengstenberg C, Hudson TJ, Järvelin MR, Kogevinas M, Loos RJ, Martin NG, Metspalu A, Pennell CE, Penninx BW, Perola M, Raitakari O, Salomaa V, Schreiber S, Schunkert H, Spector TD, Stumvoll M, Uitterlinden AG, Ulivi S, van der Harst P, Vollenweider P, Völzke H, Wareham NJ, Wichmann HE, Wilson JF, Rudan I, Xue Y, Zeggini E.
Avaldatud: Human Molecular Genetics. Vol: 21, Issue: 21, pp: 4805-15. Published: 2012-Nov-1.
DOI: 10.1093/hmg/dds304


Toward a roadmap in global biobanking for health
Harris JR, Burton P, Knoppers BM, Lindpaintner K, Bledsoe M, Brookes AJ, Budin-Ljøsne I, Chisholm R, Cox D, Deschênes M, Fortier I, Hainaut P, Hewitt R, Kaye J, Litton JE, Metspalu A, Ollier B, Palmer LJ, Palotie A, Pasterk M, Perola M, Riegman PH, van Ommen GJ, Yuille M, Zatloukal K.
Avaldatud: European Journal of Human Genetics, Jun 20.
DOI: 10.1038/ejhg.2012.96.


Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations
Yukinori Okada, Xueling Sim, Min Jin Go, Jer-Yuarn Wu, Dongfeng Gu, Fumihiko Takeuchi, Atsushi Takahashi, Shiro Maeda, Tatsuhiko Tsunoda, Peng Chen, Su-Chi Lim, Tien-Yin Wong, Jianjun Liu, Terri L Young, Tin Aung, Mark Seielstad, Yik-Ying Teo, Young Jin Kim, Jong-Young Lee, Bok-Ghee Han, Daehee Kang, Chien-Hsiun Chen, Fuu-Jen Tsai, Li-Ching Chang, S-J Cathy Fann, Hao Mei, Dabeeru C Rao, James E Hixson, Shufeng Chen, Tomohiro Katsuya, Masato Isono, Toshio Ogihara, John C Chambers, Weihua Zhang, Jaspal S Kooner, The KidneyGen Consortium, The CKDGen Consortium, Eva Albrecht, The GUGC consortium, Kazuhiko Yamamoto, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani, Norihiro Kato, Jiang He, Yuan-Tsong Chen, Yoon Shin Cho, E-Shyong Tai & Toshihiro Tanaka
Avaldatud: Nature Genetics 44, 904–909 (Published online 15 July)
DOI: 10.1038/ng.2352


Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O''Seaghdha CM, Haller T, Yang Q, Tanaka T, Johnson AD, Kutalik Z, Smith AV, Shi J, Struchalin M, Middelberg RP, Brown MJ, Gaffo AL, Pirastu N, Li G, Hayward C, Zemunik T, Huffman J, Yengo L, Zhao JH, Demirkan A, Feitosa MF, Liu X, Malerba G, Lopez LM, van der Harst P, Li X, Kleber ME, Hicks AA, Nolte IM, Johansson A, Murgia F, Wild SH, Bakker SJ, Peden JF, Dehghan A, Steri M, Tenesa A, Lagou V, Salo P, Mangino M, Rose LM, Lehtimäki T, Woodward OM, Okada Y, Tin A, Müller C, Oldmeadow C, Putku M, Czamara D, Kraft P, Frogheri L, Thun GA, Grotevendt A, Gislason GK, Harris TB, Launer LJ, McArdle P, Shuldiner AR, Boerwinkle E, Coresh J, Schmidt H, Schallert M, Martin NG, Montgomery GW, Kubo M, Nakamura Y, Tanaka T, Munroe PB, Samani NJ, Jacobs DR Jr, Liu K, D''Adamo P, Ulivi S, Rotter JI, Psaty BM, Vollenweider P, Waeber G, Campbell S, Devuyst O, Navarro P, Kolcic I, Hastie N, Balkau B, Froguel P, Esko T, Salumets A, Khaw KT, Langenberg C, Wareham NJ, Isaacs A, Kraja A, Zhang Q, Wild PS, Scott RJ, Holliday EG, Org E, Viigimaa M, Bandinelli S, Metter JE, Lupo A, Trabetti E, Sorice R, Döring A, Lattka E, Strauch K, Theis F, Waldenberger M, Wichmann HE, Davies G, Gow AJ, Bruinenberg M; LifeLines Cohort Study, Stolk RP, Kooner JS, Zhang W, Winkelmann BR, Boehm BO, Lucae S, Penninx BW, Smit JH, Curhan G, Mudgal P, Plenge RM, Portas L, Persico I, Kirin M, Wilson JF, Leach IM, van Gilst WH, Goel A, Ongen H, Hofman A, Rivadeneira F, Uitterlinden AG, Imboden M, von Eckardstein A, Cucca F, Nagaraja R, Piras MG, Nauck M, Schurmann C, Budde K, Ernst F, Farrington SM, Theodoratou E, Prokopenko I, Stumvoll M, Jula A, Perola M, Salomaa V, Shin SY, Spector TD, Sala C, Ridker PM, Kähönen M, Viikari J, Hengstenberg C, Nelson CP; CARDIoGRAM Consortium; DIAGRAM Consortium; ICBP Consortium; MAGIC Consortium, Meschia JF, Nalls MA, Sharma P, Singleton AB, Kamatani N, Zeller T, Burnier M, Attia J, Laan M, Klopp N, Hillege HL, Kloiber S, Choi H, Pirastu M, Tore S, Probst-Hensch NM, Völzke H, Gudnason V, Parsa A, Schmidt R, Whitfield JB, Fornage M, Gasparini P, Siscovick DS, Polašek O, Campbell H, Rudan I, Bouatia-Naji N, Metspalu A, Loos RJ, van Duijn CM, Borecki IB, Ferrucci L, Gambaro G, Deary IJ, Wolffenbuttel BH, Chambers JC, März W, Pramstaller PP, Snieder H, Gyllensten U, Wright AF, Navis G, Watkins H, Witteman JC, Sanna S, Schipf S, Dunlop MG, Tönjes A, Ripatti S, Soranzo N, Toniolo D, Chasman DI, Raitakari O, Kao WH, Ciullo M, Fox CS, Caulfield M, Bochud M, Gieger C.
Avaldatud: Nature Genetics
DOI: 10.1038/ng.2500


Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity
Tõnu Esko, Massimo Mezzavilla, Mari Nelis, Christelle Borel, Tadeusz Debniak, Eveliina Jakkula, Antonio Julia, Sena Karachanak, Andrey Khrunin, Peter Kisfali, Veronika Krulisova, Zita Aušrelé Kučinskiené, Karola Rehnström, Michela Traglia, Liene Nikitina-Zake, Fritz Zimprich, Stylianos E Antonarakis, Xavier Estivill, Damjan Glavač, Ivo Gut, Janis Klovins, Michael Krawczak, Vaidutis Kučinskas, Mark Lathrop, Milan Macek, Sara Marsa, Thomas Meitinger, Béla Melegh, Svetlana Limborska, Jan Lubinski, Aarno Paolotie, Stefan Schreiber, Draga Toncheva, Daniela Toniolo, H-Erich Wichmann, Alexander Zimprich, Mait Metspalu, Paolo Gasparini, Andres Metspalu and Pio D''Adamo4
Avaldatud: European Journal of Human Genetics
DOI: 10.1038/ejhg.2012.229


Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Lam C Tsoi, Sarah L Spain, Jo Knight, Eva Ellinghaus, Philip E Stuart, Francesca Capon, Jun Ding, Yanming Li, Trilokraj Tejasvi, Johann E Gudjonsson, Hyun M Kang, Michael H Allen, Ross McManus, Giuseppe Novelli, Lena Samuelsson, Joost Schalkwijk, Mona Ståhle, A David Burden, Catherine H Smith, Michael J Cork, Xavier Estivill, Anne M Bowcock, Gerald G Krueger, Wolfgang Weger, Jane Worthington, Rachid Tazi-Ahnini, Frank O Nestle, Adrian Hayday, Per Hoffmann, Juliane Winkelmann, Cisca Wijmenga, Cordelia Langford, Sarah Edkins, Robert Andrews, Hannah Blackburn, Amy Strange, Gavin Band, Richard D Pearson, Damjan Vukcevic, Chris C A Spencer, Panos Deloukas, Ulrich Mrowietz, Stefan Schreiber, Stephan Weidinger, Sulev Koks, Külli Kingo, Tonu Esko, Andres Metspalu, Henry W Lim, John J Voorhees, Michael Weichenthal, H Erich Wichmann, Vinod Chandran, Cheryl F Rosen, Proton Rahman, Dafna D Gladman, Christopher E M Griffiths, Andre Reis, Juha Kere, Collaborative Association Study of Psoriasis (CASP), Genetic Analysis of Psoriasis Consortium, Psoriasis Association Genetics Extension, Wellcome Trust Case Control Consortium 2, Rajan P Nair, Andre Franke, Jonathan N W N Barker, Goncalo R Abecasis, James T Elder & Richard C Trembath
Avaldatud: Nature Genetics 44, 1341–1348 (Published online 11 November 2012)
DOI: doi:10.1038/ng.2467


Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study (link)
arcOGEN Consortium and arcOGEN Collaborators, /…/, Esko T, Metspalu A et al.
Avaldatud: The Lancet. Published Online July 3, 2012
DOI: 10.1016/S0140-6736(12)60681-3


Evidence of Inbreeding Depression on Human Height
Ruth McQuillan, Niina Eklund, Nicola Pirastu, Maris Kuningas, Brian P. McEvoy, To ̃nu Esko, Tanguy Corre, Gail Davies, Marika Kaakinen, Leo-Pekka Lyytika ̈inen, Kati Kristiansson, Aki S. Havulinna, Martin Go ̈gele, Veronique Vitart, Albert Tenesa, Yurii Aulchenko, Caroline Hayward, A ̊sa Johansson, Mladen Boban, Sheila Ulivi, Antonietta Robino, Vesna Boraska, Wilmar Igl, Sarah H. Wild, Lina Zgaga, Najaf Amin, Evropi Theodoratou, Ozren Polasˇek, Giorgia Girotto, Lorna M. Lopez, Cinzia Sala, Jari Lahti, Tiina Laatikainen, Inga Prokopenko, Mart Kals, Jorma Viikari, Jian Yang, Anneli Pouta, Karol Estrada, Albert Hofman, Nelson Freimer, Nicholas G. Martin, Mika Ka ̈ho ̈nen, Lili Milani, Markku Helio ̈vaara, Erkki Vartiainen, Katri Ra ̈ikko ̈nen, Corrado Masciullo, John M. Starr, Andrew A. Hicks, Laura Esposito, Ivana Kolcˇic ́, Susan M. Farrington, Ben Oostra, Tatijana Zemunik, Harry Campbell, Mirna Kirin, Marina Pehlic, Flavio Faletra, David Porteous, Giorgio Pistis, Elisabeth Wide ́n, Veikko Salomaa, Seppo Koskinen, Krista Fischer, Terho Lehtima ̈ki, Andrew Heath, Mark I. McCarthy, Fernando Rivadeneira, Grant W. Montgomery, Henning Tiemeier, Anna-Liisa Hartikainen, Pamela A. F. Madden, Pio d’Adamo, Nicholas D. Hastie, Ulf Gyllensten, Alan F. Wright, Cornelia M. van Duijn, Malcolm Dunlop, Igor Rudan, Paolo Gasparini, Peter P. Pramstaller, Ian J. Deary, Daniela Toniolo, Johan G. Eriksson, Antti Jula, Olli T. Raitakari, Andres Metspalu, Markus Perola, Marjo-Riitta Ja ̈rvelin, Andre ́ Uitterlinden, Peter M. Visscher, James F. Wilson1* on behalf of the ROHgen Consortium
Avaldatud: PLOS Genetics; e1002655, July 19, 2012, Volume 8, Issue 7


Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. (link)
Verhoeven VJ, Hysi PG, Saw SM, Vitart V, Mirshahi A, Guggenheim JA, Cotch MF, Yamashiro K, Baird PN, Mackey DA, Wojciechowski R, Ikram MK, Hewitt AW, Duggal P, Janmahasatian S, Khor CC, Fan Q, Zhou X, Young TL, Tai ES, Goh LK, Li YJ, Aung T, Vithana E, Teo YY, Tay W, Sim X, Rudan I, Hayward C, Wright AF, Polasek O, Campbell H, Wilson JF, Fleck BW, Nakata I, Yoshimura N, Yamada R, Matsuda F, Ohno-Matsui K, Nag A, McMahon G, Pourcain BS, Lu Y, Rahi JS, Cumberland PM, Bhattacharya S, Simpson CL, Atwood LD, Li X, Raffel LJ, Murgia F, Portas L, Despriet DD, van Koolwijk LM, Wolfram C, Lackner KJ, Tönjes A, Mägi R, Lehtimäki T, Kähönen M, Esko T, Metspalu A, Rantanen T, Pärssinen O, Klein BE, Meitinger T, Spector TD, Oostra BA, Smith AV, de Jong PT, Hofman A, Amin N, Karssen LC, Rivadeneira F, Vingerling JR, Eiríksdóttir G, Gudnason V, Döring A, Bettecken T, Uitterlinden AG, Williams C, Zeller T, Castagné R, Oexle K, van Duijn CM, Iyengar SK, Mitchell P, Wang JJ, Höhn R, Pfeiffer N, Bailey-Wilson JE, Stambolian D, Wong TY, Hammond CJ, Klaver CC.
Avaldatud: Hum Genet. 2012 Jun 5.


Common variants at 6q22 and 17q21 are associated with intracranial volume (link)
M Arfan Ikram, Myriam Fornage, Albert V Smith, Sudha Seshadri, Reinhold Schmidt, Stéphanie Debette, Henri A Vrooman, Sigurdur Sigurdsson, Stefan Ropele, H Rob Taal, Dennis O Mook-Kanamori, Laura H Coker, W T Longstreth Jr, Wiro J Niessen, Anita L DeStefano, Alexa Beiser, Alex P Zijdenbos, Maksim Struchalin, Clifford R Jack Jr, Fernando Rivadeneira, Andre G Uitterlinden, David S Knopman, Anna-Liisa Hartikainen, Craig E Pennell, Elisabeth Thiering, Eric A P Steegers, Hakon Hakonarson, Joachim Heinrich, Lyle J Palmer, Marjo-Riitta Jarvelin, Mark I McCarthy, Struan F A Grant, Beate St Pourcain, Nicholas J Timpson, George Davey Smith, Ulla Sovio, Mike A Nalls, Rhoda Au, Albert Hofman, Haukur Gudnason, Aad van der Lugt, Tamara B Harris, William M Meeks, Meike W Vernooij, Mark A van Buchem, Diane Catellier, Vincent W V Jaddoe, Vilmundur Gudnason, B Gwen Windham, Philip A Wolf, Cornelia M van Duijn, Thomas H Mosley Jr, Helena Schmidt, Lenore J Launer, Monique M B Breteler & Charles DeCarli for the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium & Early Growth Genetics (EGG) Consortium
Avaldatud: Nature Genetics 44, 539–544 (2012)
DOI: 10.1038/ng.2245


Common variants at 12q15 and 12q24 are associated with infant head circumference (link)
H Rob Taal, Beate St Pourcain, Elisabeth Thiering, Shikta Das, Dennis O Mook-Kanamori, Nicole M Warrington, Marika Kaakinen, Eskil Kreiner-Møller, Jonathan P Bradfield, Rachel M Freathy, Frank Geller, Mònica Guxens, Diana L Cousminer, Marjan Kerkhof, Nicholas J Timpson, M Arfan Ikram, Lawrence J Beilin, Klaus Bønnelykke, Jessica L Buxton, Pimphen Charoen, Bo Lund Krogsgaard Chawes, Johan Eriksson, David M Evans, Albert Hofman, John P Kemp, Cecilia E Kim, Norman Klopp, Jari Lahti, Stephen J Lye, George McMahon, Frank D Mentch, Martina Müller-Nurasyid, Paul F O''''''''Reilly, Inga Prokopenko, Fernando Rivadeneira, Eric A P Steegers, Jordi Sunyer, Carla Tiesler, Hanieh Yaghootkar, The Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Consortium, Monique M B Breteler, Stéphanie Debette, Myriam Fornage, Vilmundur Gudnason, Lenore J Launer, Aad van der Lugt, Thomas H Mosley Jr, Sudha Seshadri, Albert V Smith, Meike W Vernooij, Early Genetics & Lifecourse Epidemiology (EAGLE) Consortium, Alexandra I F Blakemore, Rosetta M Chiavacci, Bjarke Feenstra, Julio Fernandez-Banet, Struan F A Grant, Anna-Liisa Hartikainen, Albert J van der Heijden, Carmen Iñiguez, Mark Lathrop, Wendy L McArdle, Anne Mølgaard, John P Newnham, Lyle J Palmer, Aarno Palotie, Annneli Pouta, Susan M Ring, Ulla Sovio, Marie Standl, Andre G Uitterlinden, H-Erich Wichmann, Nadja Hawwa Vissing, Charles DeCarli, Cornelia M van Duijn, Mark I McCarthy, Gerard H Koppelman, Xavier Estivill, Andrew T Hattersley, Mads Melbye, Hans Bisgaard, Craig E Pennell, Elisabeth Widen, Hakon Hakonarson, George Davey Smith, Joachim Heinrich, Marjo-Riitta Jarvelin, Vincent W V Jaddoe & Early Growth Genetics (EGG) Consortium
Avaldatud: Nature Genetics 44, 532–538 (2012)
DOI: 10.1038/ng.2238


Seventy-five genetic loci influencing the human red blood cell
Pim van der Harst, Weihua Zhang, Irene Mateo Leach, Augusto Rendon, Niek Verweij, Joban Sehmi, Dirk S. Paul, Ulrich Elling, Hooman Allayee, Xinzhong Li, Aparna Radhakrishnan, Sian-Tsung Tan, Katrin Voss, Christian X. Weichenberger, Cornelis A. Albers, Abtehale Al-Hussani, Folkert W. Asselbergs, Marina Ciullo, Fabrice Danjou, Christian Dina, Tõnu Esko, David M. Evans, Lude Franke, Martin Gögele, Jaana Hartiala, Micha Hersch, Hilma Holm, Jouke-Jan Hottenga, Stavroula Kanoni, Marcus E. Kleber, Vasiliki Lagou, Claudia Langenberg, Lorna M. Lopez, Leo-Pekka Lyytikäinen, Olle Melander, Federico Murgia, Ilja M. Nolte, Paul F. O’Reilly, Sandosh Padmanabhan, Afshin Parsa, Nicola Pirastu, Eleonora Porcu, Laura Portas, Inga Prokopenko, Janina S. Ried, So-Youn Shin, Clara S. Tang, Alexander Teumer, Michela Traglia, Sheila Ulivi, Harm-Jan Westra, Jian Yang, Jing Hua Zhao, Franco Anni, Abdel Abdellaoui, Antony Attwood, Beverley Balkau, Stefania Bandinelli, François Bastardot, Beben Benyamin, Bernhard O. Boehm, William O. Cookson, Debashish Das, Paul I. W. de Bakker, Rudolf A. de Boer, Eco J. C. de Geus, Marleen H. de Moor, Maria Dimitriou, Francisco S. Domingues, Angela Döring, Gunnar Engström, Gudmundur Ingi Eyjolfsson, Luigi Ferrucci, Krista Fischer, Renzo Galanello, Stephen F. Garner, Bernd Genser, Quince D. Gibson, Giorgia Girotto, Daniel Fannar Gudbjartsson, Sarah E. Harris, Anna-Liisa Hartikainen, Claire E. Hastie, Bo Hedblad, Thomas Illig, Jennifer Jolley, Mika Kähönen, Ido P. Kema, John P. Kemp, Liming Liang, Heather Lloyd-Jones, Ruth J. F. Loos, Stuart Meacham, Sarah E. Medland, Christa Meisinger, Yasin Memari, Evelin Mihailov, Kathy Miller, Miriam F. Moffatt, Matthias Nauck, Maria Novatchkova, Teresa Nutile, Isleifur Olafsson, Pall T. Onundarson, Debora Parracciani, Brenda W. Penninx, Lucia Perseu, Antonio Piga, Giorgio Pistis, Anneli Pouta, Ursula Puc, Olli Raitakari, Susan M. Ring, Antonietta Robino, Daniela Ruggiero, Aimo Ruokonen, Aude Saint-Pierre, Cinzia Sala, Andres Salumets, Jennifer Sambrook, Hein Schepers, Carsten Oliver Schmidt, Herman H. W. Silljé, Rob Sladek, Johannes H. Smit, John M. Starr, Jonathan Stephens, Patrick Sulem, Toshiko Tanaka, Unnur Thorsteinsdottir, Vinicius Tragante, Wiek H. van Gilst, L. Joost van Pelt, Dirk J. van Veldhuisen, Uwe Völker, John B. Whitfield, Gonneke Willemsen, Bernhard R. Winkelmann, Gerald Wirnsberger, Ale Algra, Francesco Cucca, Adamo Pio d’Adamo, John Danesh, Ian J. Deary, Anna F. Dominiczak, Paul Elliott, Paolo Fortina, Philippe Froguel, Paolo Gasparini, Andreas Greinacher, Stanley L. Hazen, Marjo-Riitta Jarvelin, Kay Tee Khaw, Terho Lehtimäki, Winfried Maerz, Nicholas G. Martin, Andres Metspalu, Braxton D. Mitchell, Grant W. Montgomery, Carmel Moore, Gerjan Navis, Mario Pirastu, Peter P. Pramstaller, Ramiro Ramirez-Solis, Eric Schadt, James Scott, Alan R. Shuldiner, George Davey Smith, J. Gustav Smith, Harold Snieder, Rossella Sorice, Tim D. Spector, Kari Stefansson, Michael Stumvoll, W. H. Wilson Tang, Daniela Toniolo, Anke Tönjes, Peter M. Visscher, Peter Vollenweider, Nicholas J. Wareham, Bruce H. R. Wolffenbuttel, Dorret I. Boomsma, Jacques S. Beckmann, George V. Dedoussis, Panos Deloukas, Manuel A. Ferreira, Serena Sanna, Manuela Uda, Andrew A. Hicks, Josef Martin Penninger, Christian Gieger, Jaspal S. Kooner, Willem H. Ouwehand, Nicole Soranzo & John C. Chambers
Avaldatud: Nature - Received 06 February 2012 Accepted 15 October 2012 Published online 05 December 2012
DOI: 10.1038/nature11677


Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis Identifies Seven Shared Susceptibility Loci (link)
David Ellinghaus, Eva Ellinghaus, Rajan P. Nair, Philip E. Stuart, Tõnu Esko, Andres Metspalu, Sophie Debrus, John V. Raelson, Trilokraj Tejasvi, Majid Belouchi, Sarah L. West, Jonathan N. Barker, Sulev Kõks, Külli Kingo, Tobias Balschun, Orazio Palmieri, Vito Annese, Christian Gieger, H. Erich Wichmann, Michael Kabesch, Richard C. Trembath, Christopher G. Mathew, Gonçalo R. Abecasis, Stephan Weidinger, Susanna Nikolaus, Stefan Schreiber, James T. Elder, Michael Weichenthal, Michael Nothnagel, Andre Franke Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA Estonian Genome Center, University of Tartu, 50409 Tartu, Estonia Institute of Molecular and Cell Biology, University of Tartu, 50409 Tartu, Estonia Gatineau, QC J9J 2X6, Canada PGX-Services, Montreal, QC H2T 1S1, Canada Genizon BioSciences, Inc., St. Laurent, QC H4T 2C7, Canada Division of Genetics and Molecular Medicine, King''''''''s College London, London SE1 9RT, UK Department of Physiology, Centre of Translational Medicine and Centre of Translational Genomics, University of Tartu, 50409 Tartu, Estonia Department of Dermatology and Venerology, University of Tartu, 50409 Tartu, Estonia Division of Gastroenterology, Istituto di Ricovero e Cura a Carattere Scientifico-Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo 71013, Italy Unit of Gastroenterology SOD2, Azienda Ospedaliero Universitaria Careggi, Florence 50134, Italy Institute of Genetic Epidemiology, Helmholtz Centre Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany Institute of Epidemiology I, Helmholtz Centre Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, 81377 Munich, Germany Klinikum Grosshadern, 81377 Munich, Germany Department of Paediatric Pneumology, Allergy and Neonatology, Hannover Medical School, 30625 Hannover, Germany Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA 19 Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, 24105 Kiel, Germany PopGen Biobank, Christian-Albrechts-University Kiel, 24105 Kiel, Germany Department of General Internal Medicine, University Hospital Schleswig-Holstein, 24105 Kiel, Germany 22 Ann Arbor Veterans Affairs Hopital, Ann Arbor, MI 48105, USA 23 Institute of Medical Informatics and Statistics, Christian-Albrechts University, 24105 Kiel, Germany
Avaldatud: AJHG Volume 90, Issue 4, 6 April 2012, Pages 636–647
DOI: 10.1016/j.ajhg.2012.02.020.


The Estonian Genome Center of the University of Tartu at the disposal of scientists. Tartu Ülikooli Eesti geenivaramu on teadlaste käsutuses.
Alavere H, Fischer K, Esko T, Leitsalu-Moynihan L, Metspalu A.
Avaldatud: Est Med J 91 / Eesti Arst 2012;91(4):190-198.


Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function (link)
Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O''''Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O''''Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa M, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Chouraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; Wellcome Trust Case Control Consortium 2 (WTCCC2), Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu FB, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Koenig W, Illig T, Döring A, Wichmann HE, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Endlich K, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Ruggiero D, Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Giulianini F, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Metzger M, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki I, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman JC, Hayward C, Ridker P, Parsa A, Bochud M, Heid IM, Goessling W, Chasman DI, Kao WH, Fox CS
Avaldatud: PLoS Genetics 8(3): e1002584 March 29, 2012
DOI: 10.1371/journal.pgen.1002584


A genome-wide association meta-analysis identifies new childhood obesity loci
Jonathan P Bradfield, H Rob Taal, Nicholas J Timpson, André Scherag, Cecile Lecoeur, Nicole M Warrington, Elina Hypponen, Claus Holst, Beatriz Valcarcel, Elisabeth Thiering, Rany M Salem, Fredrick R Schumacher, Diana L Cousminer, Patrick M A Sleiman, Jianhua Zhao, Robert I Berkowitz, Karani S Vimaleswaran, Ivonne Jarick, Craig E Pennell, David M Evans, Beate St Pourcain, Diane J Berry, Dennis O Mook-Kanamori, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Cornelia M van Duijn, Ralf J P van der Valk, Johan C de Jongste, Dirkje S Postma, Dorret I Boomsma, W James Gauderman, Mohamed T Hassanein, Cecilia M Lindgren, Reedik Mägi, Colin A G Boreham, Charlotte E Neville, Luis A Moreno, Paul Elliott, Anneli Pouta, Anna-Liisa Hartikainen, Mingyao Li, Olli Raitakari, Terho Lehtimäki, Johan G Eriksson, Aarno Palotie, Jean Dallongeville, Shikta Das, Panos Deloukas, George McMahon, Susan M Ring, John P Kemp, Jessica L Buxton, Alexandra I F Blakemore, Mariona Bustamante, Mònica Guxens, Joel N Hirschhorn, Matthew W Gillman, Eskil Kreiner-Møller, Hans Bisgaard, Frank D Gilliland, Joachim Heinrich, Eleanor Wheeler, Inês Barroso, Stephen O’Rahilly, Aline Meirhaeghe, Thorkild I A Sørensen, Chris Power, Lyle J Palmer, Anke Hinney, Elisabeth Widen, I Sadaf Farooqi, Mark I McCarthy, Philippe Froguel, David Meyre, Johannes Hebebrand, Marjo-Riitta Jarvelin, Vincent W V Jaddoe, George Davey Smith, Hakon Hakonarson & Struan F A Grant for the Early Growth Genetics (EGG) Consortium
Avaldatud: Nature Genetics, Published Online 15. April 2012


Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes
Josine L. Min, George Nicholson, Ingileif Halgrimsdottir, Kristian Almstrup, Andreas Petri, Amy Barrett, Mary Travers, Nigel W. Rayner, Reedik Mägi, Fredrik H. Pettersson, John Broxholme, Matt J. Neville, Quin F. Wills, Jane Cheeseman, The GIANT Consortium", The MolPAGE Consortium", Maxine Allen, Chris C. Holmes, Tim D. Spector, Jan Fleckner, Mark I. McCarthy, Fredrik Karpe, Cecilia M. Lindgren, Krina T. Zondervan
Avaldatud: PLoS Genetics, February 2012 | Volume 8 | Issue 2,
DOI: 10.1371/journal.pgen.1002505


Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways (link)
Stolk L, Perry JR, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, Esko T, Franceschini N, Gudbjartsson DF, Hottenga JJ, Kraft P, McArdle PF, Porcu E, Shin SY, Smith AV, van Wingerden S, Zhai G, Zhuang WV, Albrecht E, Alizadeh BZ, Aspelund T, Bandinelli S, Lauc LB, Beckmann JS, Boban M, Boerwinkle E, Broekmans FJ, Burri A, Campbell H, Chanock SJ, Chen C, Cornelis MC, Corre T, Coviello AD, d''Adamo P, Davies G, de Faire U, de Geus EJ, Deary IJ, Dedoussis GV, Deloukas P, Ebrahim S, Eiriksdottir G, Emilsson V, Eriksson JG, Fauser BC, Ferreli L, Ferrucci L, Fischer K, Folsom AR, Garcia ME, Gasparini P, Gieger C, Glazer N, Grobbee DE, Hall P, Haller T, Hankinson SE, Hass M, Hayward C, Heath AC, Hofman A, Ingelsson E, Janssens AC, Johnson AD, Karasik D, Kardia SL, Keyzer J, Kiel DP, Kolcic I, Kutalik Z, Lahti J, Lai S, Laisk T, Laven JS, Lawlor DA, Liu J, Lopez LM, Louwers YV, Magnusson PK, Marongiu M, Martin NG, Klaric IM, Masciullo C, McKnight B, Medland SE, Melzer D, Mooser V, Navarro P, Newman AB, Nyholt DR, Onland-Moret NC, Palotie A, Paré G, Parker AN, Pedersen NL, Peeters PH, Pistis G, Plump AS, Polasek O, Pop VJ, Psaty BM, Räikkönen K, Rehnberg E, Rotter JI, Rudan I, Sala C, Salumets A, Scuteri A, Singleton A, Smith JA, Snieder H, Soranzo N, Stacey SN, Starr JM, Stathopoulou MG, Stirrups K, Stolk RP, Styrkarsdottir U, Sun YV, Tenesa A, Thorand B, Toniolo D, Tryggvadottir L, Tsui K, Ulivi S, van Dam RM, van der Schouw YT, van Gils CH, van Nierop P, Vink JM, Visscher PM, Voorhuis M, Waeber G, Wallaschofski H, Wichmann HE, Widen E, Wijnands-van Gent CJ, Willemsen G, Wilson JF, Wolffenbuttel BH, Wright AF, Yerges-Armstrong LM, Zemunik T, Zgaga L, Zillikens MC, Zygmunt M, Study TL, Arnold AM, Boomsma DI, Buring JE, Crisponi L, Demerath EW, Gudnason V, Harris TB, Hu FB, Hunter DJ, Launer LJ, Metspalu A, Montgomery GW, Oostra BA, Ridker PM, Sanna S, Schlessinger D, Spector TD, Stefansson K, Streeten EA, Thorsteinsdottir U, Uda M, Uitterlinden AG, van Duijn CM, Völzke H, Murray A, Murabito JM, Visser JA, Lunetta KL.
Avaldatud: Nat Genet. 2012 Jan 22;44(3):260-8
DOI: 10.1038/ng.1051


Post-translational stabilization of thiopurine S-methyltransferase by S-adenosyl-l-methionine reveals regulation of TPMT*1 and *3C allozymes.
Milek M, Smid A, Tamm R, Kuzelicki NK, Metspalu A, Mlinaric-Rascan I.
Avaldatud: Biochem Pharmacol. Epub 2012 Jan 17.
DOI: 10.1016/j.bcp.2012.01.010


Personality traits and eating habits in a large sample of Estonians
Mõttus R, Realo A, Allik J, Deary IJ, Esko T, Metspalu A.
Avaldatud: Health Psychology. Epub 2012 Jan 23.
DOI: 10.1037/a0027041


Longevity candidate genes and their association with personality traits in the elderly.
Luciano M, Lopez LM, de Moor MH, Harris SE, Davies G, Nutile T, Krueger RF, Esko T, Schlessinger D, Toshiko T, Derringer JL, Realo A, Hansell NK, Pergadia ML, Pesonen AK, Sanna S, Terracciano A, Madden PA, Penninx B, Spinhoven P, Hartman CA, Oostra BA, Janssens AC, Eriksson JG, Starr JM, Cannas A, Ferrucci L, Metspalu A, Wright MJ, Heath AC, van Duijn CM, Bierut LJ, Raikkonen K, Martin NG, Ciullo M, Rujescu D, Boomsma DI, Deary IJ.
Avaldatud: Am J Med Genet B Neuropsychiatr Genet. 2012 Mar;159B(2):192-200. doi: 10.1002/ajmg.b.32013. Epub 2011 Dec 27
DOI: 10.1002/ajmg.b.32013.

 

2011 (32)

The Lin28/let-7 axis regulates glucose metabolism.
Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI; DIAGRAM Consortium; MAGIC Investigators, Altshuler D, Daley GQ.
Avaldatud: Cell. 2011 Sep 30;147(1):81-94
DOI: doi: 10.1016/j.cell.2011.08.033


Assessing the impact of missing genotype data in rare variant association analysis
Mägi R, Kumar A, Morris AP.
Avaldatud: BMC Proc. 2011 Nov 29;5 Suppl 9:S107
DOI: 10.1186/1753-6561-5-S9-S107


A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, Jackson AU, Johnson T, Kanoni S, Ladenvall C, Lagou V, Lahti J, Lecoeur C, Liu Y, Martinez-Larrad MT, Montasser ME, Navarro P, Perry JR, Rasmussen-Torvik LJ, Salo P, Sattar N, Shungin D, Strawbridge RJ, Tanaka T, van Duijn CM, An P, de Andrade M, Andrews JS, Aspelund T, Atalay M, Aulchenko Y, Balkau B, Bandinelli S, Beckmann JS, Beilby JP, Bellis C, Bergman RN, Blangero J, Boban M, Boehnke M, Boerwinkle E, Bonnycastle LL, Boomsma DI, Borecki IB, Böttcher Y, Bouchard C, Brunner E, Budimir D, Campbell H, Carlson O, Chines PS, Clarke R, Collins FS, Corbatón-Anchuelo A, Couper D, de Faire U, Dedoussis GV, Deloukas P, Dimitriou M, Egan JM, Eiriksdottir G, Erdos MR, Eriksson JG, Eury E, Ferrucci L, Ford I, Forouhi NG, Fox CS, Franzosi MG, Franks PW, Frayling TM, Froguel P, Galan P, de Geus E, Gigante B, Glazer NL, Goel A, Groop L, Gudnason V, Hallmans G, Hamsten A, Hansson O, Harris TB, Hayward C, Heath S, Hercberg S, Hicks AA, Hingorani A, Hofman A, Hui J, Hung J, Jarvelin MR, Jhun MA, Johnson PC, Jukema JW, Jula A, Kao WH, Kaprio J, Kardia SL, Keinanen-Kiukaanniemi S, Kivimaki M, Kolcic I, Kovacs P, Kumari M, Kuusisto J, Kyvik KO, Laakso M, Lakka T, Lannfelt L, Lathrop GM, Launer LJ, Leander K, Li G, Lind L, Lindstrom J, Lobbens S, Loos RJ, Luan J, Lyssenko V, Mägi R, Magnusson PK, Marmot M, Meneton P, Mohlke KL, Mooser V, Morken MA, Miljkovic I, Narisu N, O''Connell J, Ong KK, Oostra BA, Palmer LJ, Palotie A, Pankow JS, Peden JF, Pedersen NL, Pehlic M, Peltonen L, Penninx B, Pericic M, Perola M, Perusse L, Peyser PA, Polasek O, Pramstaller PP, Province MA, Räikkönen K, Rauramaa R, Rehnberg E, Rice K, Rotter JI, Rudan I, Ruokonen A, Saaristo T, Sabater-Lleal M, Salomaa V, Savage DB, Saxena R, Schwarz P, Seedorf U, Sennblad B, Serrano-Rios M, Shuldiner AR, Sijbrands EJ, Siscovick DS, Smit JH, Small KS, Smith NL, Smith AV, Stančáková A, Stirrups K, Stumvoll M, Sun YV, Swift AJ, Tönjes A, Tuomilehto J, Trompet S, Uitterlinden AG, Uusitupa M, Vikström M, Vitart V, Vohl MC, Voight BF, Vollenweider P, Waeber G, Waterworth DM, Watkins H, Wheeler E, Widen E, Wild SH, Willems SM, Willemsen G, Wilson JF, Witteman JC, Wright AF, Yaghootkar H, Zelenika D, Zemunik T, Zgaga L; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium; Multiple Tissue Human Expression Resource (MUTHER) Consortium, Wareham NJ, McCarthy MI, Barroso I, Watanabe RM, Florez JC, Dupuis J, Meigs JB, Langenberg C.
Avaldatud: Nat Genet. 2012 May 13;44(6):659-69.
DOI: 10.1038/ng.2274


A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (link)
McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, Benhamou S, Bouchardy C, Ahrens W, Merletti F, Richiardi L, Talamini R, Barzan L, Kjaerheim K, Macfarlane GJ, Macfarlane TV, Simonato L, Canova C, Agudo A, Castellsagué X, Lowry R, Conway DI, McKinney PA, Healy CM, Toner ME, Znaor A, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Neto JE, Garrote LF, Boccia S, Cadoni G, Arzani D, Olshan AF, Weissler MC, Funkhouser WK, Luo J, Lubiński J, Trubicka J, Lener M, Oszutowska D, Schwartz SM, Chen C, Fish S, Doody DR, Muscat JE, Lazarus P, Gallagher CJ, Chang SC, Zhang ZF, Wei Q, Sturgis EM, Wang LE, Franceschi S, Herrero R, Kelsey KT, McClean MD, Marsit CJ, Nelson HH, Romkes M, Buch S, Nukui T, Zhong S, Lacko M, Manni JJ, Peters WH, Hung RJ, McLaughlin J, Vatten L, Njølstad I, Goodman GE, Field JK, Liloglou T, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Quirós JR, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Khaw KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Välk K, Vooder T, Metspalu A, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Blanché H, Gut IG, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P.
Avaldatud: PLoS Genet. 2011 Mar;7(3):e1001333. Epub 2011 Mar 17. Erratum in: PLoS Genet. 2011 Apr;7(4).


Manifesto for a European Anxiety Disorders Research Network
David S. Baldwin, Christer Allgulander, Alfredo Carlo Altamura, Jules Angst, Borwin Bandelow, Johan den Boer, Patrice Boyer, Simon Davies, Bernardo dell''Osso, Elias Eriksson, Naomi Fineberg, Mats Fredrikson, Andres Herran, Eduard Maron, Andres Metspalu, David Nutt, Nic van der Wee, Jose Luis Vázquez-Barquero and Joseph Zohar
Avaldatud: European Neuropsychopharmacology, Volume 20, Issue 6, June 2010, Pages 426-432


A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. (link)
Allebrandt KV, Amin N, Müller-Myhsok B, Esko T, Teder-Laving M, Azevedo RV, Hayward C, van Mill J, Vogelzangs N, Green EW, Melville SA, Lichtner P, Wichmann HE, Oostra BA, Janssens AC, Campbell H, Wilson JF, Hicks AA, Pramstaller PP, Dogas Z, Rudan I, Merrow M, Penninx B, Kyriacou CP, Metspalu A, van Duijn CM, Meitinger T, Roenneberg T.
Avaldatud: Mol Psychiatry. 2011 Nov 22.
DOI: doi: 10.1038/mp.2011.142.


Genome-Wide Meta-Analysis of Psoriatic Arthritis Identifies Susceptibility Locus at REL.
Ellinghaus E, Stuart PE, Ellinghaus D, Nair RP, Debrus S, Raelson JV, Belouchi M, Tejasvi T, Li Y, Tsoi LC, Onken AT, Esko T, Metspalu A, Rahman P, Gladman DD, Bowcock AM, Helms C, Krueger GG, Koks S, Kingo K, Gieger C, Wichmann HE, Mrowietz U, Weidinger S, Schreiber S, Abecasis GR, Elder JT, Weichenthal M, Franke A.
Avaldatud: J Invest Dermatol. 2011 Dec 15.
DOI: doi: 10.1038/jid.2011.415.


New gene functions in megakaryopoiesis and platelet formation. (link)
Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y, Lopez LM, Mägi R, Meacham S, Okada Y, Pirastu N, Sorice R, Teumer A, Voss K, Zhang W, Ramirez-Solis R, Bis JC, Ellinghaus D, Gögele M, Hottenga JJ, Langenberg C, Kovacs P, O''Reilly PF, Shin SY, Esko T, Hartiala J, Kanoni S, Murgia F, Parsa A, Stephens J, van der Harst P, Ellen van der Schoot C, Allayee H, Attwood A, Balkau B, Bastardot F, Basu S, Baumeister SE, Biino G, Bomba L, Bonnefond A, Cambien F, Chambers JC, Cucca F, D''Adamo P, Davies G, de Boer RA, de Geus EJ, Döring A, Elliott P, Erdmann J, Evans DM, Falchi M, Feng W, Folsom AR, Frazer IH, Gibson QD, Glazer NL, Hammond C, Hartikainen AL, Heckbert SR, Hengstenberg C, Hersch M, Illig T, Loos RJ, Jolley J, Tee Khaw K, Kühnel B, Kyrtsonis MC, Lagou V, Lloyd-Jones H, Lumley T, Mangino M, Maschio A, Mateo Leach I, McKnight B, Memari Y, Mitchell BD, Montgomery GW, Nakamura Y, Nauck M, Navis G, Nöthlings U, Nolte IM, Porteous DJ, Pouta A, Pramstaller PP, Pullat J, Ring SM, Rotter JI, Ruggiero D, Ruokonen A, Sala C, Samani NJ, Sambrook J, Schlessinger D, Schreiber S, Schunkert H, Scott J, Smith NL, Snieder H, Starr JM, Stumvoll M, Takahashi A, Tang WH, Taylor K, Tenesa A, Lay Thein S, Tönjes A, Uda M, Ulivi S, van Veldhuisen DJ, Visscher PM, Völker U, Wichmann HE, Wiggins KL, Willemsen G, Yang TP, Hua Zhao J, Zitting P, Bradley JR, Dedoussis GV, Gasparini P, Hazen SL, Metspalu A, Pirastu M, Shuldiner AR, Joost van Pelt L, Zwaginga JJ, Boomsma DI, Deary IJ, Franke A, Froguel P, Ganesh SK, Jarvelin MR, Martin NG, Meisinger C, Psaty BM, Spector TD, Wareham NJ, Akkerman JW, Ciullo M, Deloukas P, Greinacher A, Jupe S, Kamatani N, Khadake J, Kooner JS, Penninger J, Prokopenko I, Stemple D, Toniolo D, Wernisch L, Sanna S, Hicks AA, Rendon A, Ferreira MA, Ouwehand WH, Soranzo N
Avaldatud: Nature. 2011 Nov 30;480(7376):201-8.
DOI: doi: 10.1038/nature10659.


Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O''Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O''Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM; Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium (incl. Esko T., Mägi R., Teder-Laving, M, Nelis, M, Alevere H., Tammesoo M.-L., Metspalu A.); Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS.
Avaldatud: Nat Genet. 2011 Oct 16;43(11):1131-8
DOI: doi: 10.1038/ng.970.


The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
CM Middeldorp, MHM de Moor, LM McGrath, SD Gordon, DH Blackwood, PT Costa, A Terracciano, RF Krueger, EJC de Geus, DR Nyholt, T Tanaka, T Esko, PAF Madden, J Derringer, N Amin, G Willemsen, J-J Hottenga, MA Distel M Uda, S Sanna, P Spinhoven, CA Hartman, S Ripke, PF Sullivan, A Realo, J Allik, AC Heath, ML Pergadia, A Agrawal, P Lin, RA Grucza, E Widen, DL Cousminer, JG Eriksson, A Palotie, JH Barnett, PH Lee, M Luciano, A Tenesa, G Davies, LM Lopez, NK Hansell, SE Medland, L Ferrucci, D Schlessinger, GW Montgomery, MJ Wright, YS Aulchenko, ACJW Janssens, BA Oostra, A Metspalu, GR Abecasis, IJ Deary, K Räikkönen, LJ Bierut, NG Martin, NR Wray, CM van Duijn, JW Smoller, BWJH Penninx and DI Boomsma
Avaldatud: Translational Psychiatry (2011) 1,e49
DOI: doi:10.1038/tp.2011.45


Longevity candidate genes and their association with personality traits in the elderly.
Luciano M, Lopez LM, de Moor MH, Harris SE, Davies G, Nutile T, Krueger RF, Esko T, Schlessinger D, Toshiko T, Derringer JL, Realo A, Hansell NK, Pergadia ML, Pesonen AK, Sanna S, Terracciano A, Madden PA, Penninx B, Spinhoven P, Hartman CA, Oostra BA, Janssens AC, Eriksson JG, Starr JM, Cannas A, Ferrucci L, Metspalu A, Wright MJ, Heath AC, van Duijn CM, Bierut LJ, Raikkonen K, Martin NG, Ciullo M, Rujescu D, Boomsma DI, Deary IJ.
Avaldatud: Am J Med Genet B Neuropsychiatr Genet. 2011 Dec 27.
DOI: doi: 10.1002/ajmg.b.32013.


Giving and Withholding of Information following Genomic Screening: Challenges Identified in a Study of Primary Care Physicians in Estonia
Liis Leitsalu, Laura Hercher, Andres Metspalu
Avaldatud: J Genet Counsel, Published on-line 08.12.11,
DOI: DOI 10.1007/s10897-011-9424-3


The role of a Bioresource Research Impact Factor as an incentive to share human bioresources.
Cambon-Thomsen, A., Thorisson, G. a, Mabile, L., Andrieu, S., Bertier, G., Boeckhout, M., Carpenter, J., Dagher, G., Dalgleish, R., Deschênes, M., di Donato, J.H., Filocamo, M., Goldberg, M., Hewitt, R., Hofman, P., Kauffmann, F., Leitsalu, L., Lomba, I., Melegh, B., Metspalu, A., Miranda, L., Napolitani, F., Oestergaard, M.Z., Parodi, B., Pasterk, M., Reiche, A., Rial-Sebbag, E., Rivalle, G., Rochaix, P., Susbielle, G., Tarasova, L., Thomsen, M., Zawati, M.H. & Zins, M.
Avaldatud: Nature genetics 43, 503-4


A Variant in MCF2L Is Associated with Osteoarthritis.
Day-Williams, A.G., Southam, L., Panoutsopoulou, K., Rayner, N.W., Esko, T., Estrada, K., Helgadottir, H.T., Hofman, A., Ingvarsson, T., Jonsson, H., Keis, A., Kerkhof, H.J.M., Thorleifsson, G., Arden, N.K., Carr, A., Chapman, K., Deloukas, P., Loughlin, J., McCaskie, A., Ollier, W.E.R., Ralston, S.H., Spector, T.D., Wallis, G.A., Wilkinson, J.M., Aslam, N., Birell, F., Carluke, I., Joseph, J., Rai, A., Reed, M., Walker, K., Doherty, S.A., Jonsdottir, I., Maciewicz, R.A., Muir, K.R., Metspalu, A., Rivadeneira, F., Stefansson, K., Styrkarsdottir, U., Uitterlinden, A.G., van Meurs, J.B.J., Zhang, W., Valdes, A.M., Doherty, M. & Zeggini, E.
Avaldatud: American journal of human genetics 89, 446-50


New gene functions in megakaryopoiesis and platelet formation.
Gieger, C., Radhakrishnan, A., Cvejic, A., Tang, W., Porcu, E., Pistis, G., Serbanovic-Canic, J., Elling, U., Goodall, A.H., Labrune, Y., Lopez, L.M., Mägi, R., Meacham, S., Okada, Y., Pirastu, N., Sorice, R., Teumer, A., Voss, K., Zhang, W., Ramirez-Solis, R., Bis, J.C., Ellinghaus, D., Gögele, M., Hottenga, J.-J., Langenberg, C., Kovacs, P., O’Reilly, P.F., Shin, S.-Y., Esko, T., Hartiala, J., Kanoni, S., Murgia, F., Parsa, A., Stephens, J., van der Harst, P., Ellen van der Schoot, C., Allayee, H., Attwood, A., Balkau, B., Bastardot, F., Basu, S., Baumeister, S.E., Biino, G., Bomba, L., Bonnefond, A., Cambien, F., Chambers, J.C., Cucca, F., D’Adamo, P., Davies, G., de Boer, R.A., de Geus, E.J.C., Döring, A., Elliott, P., Erdmann, J., Evans, D.M., Falchi, M., Feng, W., Folsom, A.R., Frazer, I.H., Gibson, Q.D., Glazer, N.L., Hammond, C., Hartikainen, A.-L., Heckbert, S.R., Hengstenberg, C., Hersch, M., Illig, T., Loos, R.J.F., Jolley, J., Tee Khaw, K., Kühnel, B., Kyrtsonis, M.-C., Lagou, V., Lloyd-Jones, H., Lumley, T., Mangino, M., Maschio, A., Mateo Leach, I., McKnight, B., Memari, Y., Mitchell, B.D., Montgomery, G.W., Nakamura, Y., Nauck, M., Navis, G., Nöthlings, U., Nolte, I.M., Porteous, D.J., Pouta, A., Pramstaller, P.P., Pullat, J., Ring, S.M., Rotter, J.I., Ruggiero, D., Ruokonen, A., Sala, C., Samani, N.J., Sambrook, J., Schlessinger, D., Schreiber, S., Schunkert, H., Scott, J., Smith, N.L., Snieder, H., Starr, J.M., Stumvoll, M., Takahashi, A., Wilson Tang, W.H., Taylor, K., Tenesa, A., Lay Thein, S., Tönjes, A., Uda, M., Ulivi, S., van Veldhuisen, D.J., Visscher, P.M., Völker, U., Wichmann, H.-E., Wiggins, K.L., Willemsen, G., Yang, T.-P., Hua Zhao, J., Zitting, P., Bradley, J.R., Dedoussis, G.V., Gasparini, P., Hazen, S.L., Metspalu, A., Pirastu, M., Shuldiner, A.R., Joost van Pelt, L., Zwaginga, J.-J., Boomsma, D.I., Deary, I.J., Franke, A., Froguel, P., Ganesh, S.K., Jarvelin, M.-R., Martin, N.G., Meisinger, C., Psaty, B.M., Spector, T.D., Wareham, N.J., Akkerman, J.-W.N., Ciullo, M., Deloukas, P., Greinacher, A., Jupe, S., Kamatani, N., Khadake, J., Kooner, J.S., Penninger, J., Prokopenko, I., Stemple, D., Toniolo, D., Wernisch, L., Sanna, S., Hicks, A.A., Rendon, A., Ferreira, M.A., Ouwehand, W.H. & Soranzo, N.
Avaldatud: Nature


A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. (link)
Surakka I, Isaacs A, Karssen LC, Laurila PP, Middelberg RP, Tikkanen E, Ried JS, Lamina C, Mangino M, Igl W, Hottenga JJ, Lagou V, van der Harst P, Mateo Leach I, Esko T, Kutalik Z, Wainwright NW, Struchalin MV, Sarin AP, Kangas AJ, Viikari JS, Perola M, Rantanen T, Petersen AK, Soininen P, Johansson A, Soranzo N, Heath AC, Papamarkou T, Prokopenko I, Tönjes A, Kronenberg F, Döring A, Rivadeneira F, Montgomery GW, Whitfield JB, Kähönen M, Lehtimäki T, Freimer NB, Willemsen G, de Geus EJ, Palotie A, Sandhu MS, Waterworth DM, Metspalu A, Stumvoll M, Uitterlinden AG, Jula A, Navis G, Wijmenga C, Wolffenbuttel BH, Taskinen MR, Ala-Korpela M, Kaprio J, Kyvik KO, Boomsma DI, Pedersen NL, Gyllensten U, Wilson JF, Rudan I, Campbell H, Pramstaller PP, Spector TD, Witteman JC, Eriksson JG, Salomaa V, Oostra BA, Raitakari OT, Wichmann HE, Gieger C, Järvelin MR, Martin NG, Hofman A, McCarthy MI, Peltonen L, van Duijn CM, Aulchenko YS, Ripatti S; for the ENGAGE Consortium
Avaldatud: PLoS Genet. 2011 Oct;7(10):e1002333. Epub 2011 Oct 20.


The role of COX-2 and Nrf2/ARE in anti-inflammation and antioxidative stress: Aging and anti-aging.
Luo, C., Urgard, E., Vooder, T. & Metspalu, A.
Avaldatud: Medical hypotheses 77, 174-8


Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways.
Muiños-Gimeno, M., Espinosa-Parrilla, Y., Guidi, M., Kagerbauer, B., Sipilä, T., Maron, E., Pettai, K., Kananen, L., Navinés, R., Martín-Santos, R., Gratacòs, M., Metspalu, A., Hovatta, I. & Estivill, X.
Avaldatud: Biological psychiatry 69, 526-33


Variation in FGF1, FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate.
Nikopensius, T., Kempa, I., Ambrozaitytė, L., Jagomägi, T., Saag, M., Matulevičienė, A., Utkus, A., Krjutškov, K., Tammekivi, V., Piekuse, L., Akota, I., Barkane, B., Krumina, A., Klovins, J., Lace, B., Kučinskas, V. & Metspalu, A.
Avaldatud: Birth defects research. Part A, Clinical and molecular teratology 91, 218-25


Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study.
Panoutsopoulou, K., Southam, L., Elliott, K.S., Wrayner, N., Zhai, G., Beazley, C., Thorleifsson, G., Arden, N.K., Carr, A., Chapman, K., Deloukas, P., Doherty, M., McCaskie, A., Ollier, W.E.R., Ralston, S.H., Spector, T.D., Valdes, A.M., Wallis, G.A., Wilkinson, J.M., Arden, E., Battley, K., Blackburn, H., Blanco, F.J., Bumpstead, S., Cupples, L.A., Day-Williams, A.G., Dixon, K., Doherty, S.A., Esko, T., Evangelou, E., Felson, D., Gomez-Reino, J.J., Gonzalez, A., Gordon, A., Gwilliam, R., Halldorsson, B.V., Hauksson, V.B., Hofman, A., Hunt, S.E., Ioannidis, J.P.A., Ingvarsson, T., Jonsdottir, I., Jonsson, H., Keen, R., Kerkhof, H.J.M., Kloppenburg, M.G., Koller, N., Lakenberg, N., Lane, N.E., Lee, A.T., Metspalu, A., Meulenbelt, I., Nevitt, M.C., O’Neill, F., Parimi, N., Potter, S.C., Rego-Perez, I., Riancho, J.A., Sherburn, K., Slagboom, P.E., Stefansson, K., Styrkarsdottir, U., Sumillera, M., Swift, D., Thorsteinsdottir, U., Tsezou, A., Uitterlinden, A.G., van Meurs, J.B.J., Watkins, B., Wheeler, M., Mitchell, S., Zhu, Y., Zmuda, J.M., Zeggini, E. & Loughlin, J.
Avaldatud: Annals of the rheumatic diseases 70, 864-7


Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.
Schumann, G., Coin, L.J., Lourdusamy, A., Charoen, P., Berger, K.H., Stacey, D., Desrivières, S., Aliev, F.A., Khan, A.A., Amin, N., Aulchenko, Y.S., Bakalkin, G., Bakker, S.J., Balkau, B., Beulens, J.W., Bilbao, A., de Boer, R.A., Beury, D., Bots, M.L., Breetvelt, E.J., Cauchi, S., Cavalcanti-Proença, C., Chambers, J.C., Clarke, T.-K., Dahmen, N., de Geus, E.J., Dick, D., Ducci, F., Easton, A., Edenberg, H.J., Esko, T., Esk, T., Fernández-Medarde, A., Foroud, T., Freimer, N.B., Girault, J.-A., Grobbee, D.E., Guarrera, S., Gudbjartsson, D.F., Hartikainen, A.-L., Heath, A.C., Hesselbrock, V., Hofman, A., Hottenga, J.-J., Isohanni, M.K., Kaprio, J., Khaw, K.-T., Kuehnel, B., Laitinen, J., Lobbens, S., Luan, J., Mangino, M., Maroteaux, M., Matullo, G., McCarthy, M.I., Mueller, C., Navis, G., Numans, M.E., Núñez, A., Nyholt, D.R., Onland-Moret, C.N., Oostra, B.A., O’Reilly, P.F., Palkovits, M., Penninx, B.W., Polidoro, S., Pouta, A., Prokopenko, I., Ricceri, F., Santos, E., Smit, J.H., Soranzo, N., Song, K., Sovio, U., Stumvoll, M., Surakk, I., Thorgeirsson, T.E., Thorsteinsdottir, U., Troakes, C., Tyrfingsson, T., Tönjes, A., Uiterwaal, C.S., Uitterlinden, A.G., van der Harst, P., van der Schouw, Y.T., Staehlin, O., Vogelzangs, N., Vollenweider, P., Waeber, G., Wareham, N.J., Waterworth, D.M., Whitfield, J.B., Wichmann, E.H., Willemsen, G., Witteman, J.C., Yuan, X., Zhai, G., Zhao, J.H., Zhang, W., Martin, N.G., Metspalu, A., Doering, A., Scott, J., Spector, T.D., Loos, R.J., Boomsma, D.I., Mooser, V., Peltonen, L., Stefansson, K., van Duijn, C.M., Vineis, P., Sommer, W.H., Kooner, J.S., Spanagel, R., Heberlein, U.A., Jarvelin, M.-R. & Elliott, P.
Avaldatud: Proceedings of the National Academy of Sciences of the United States of America 108, 7119-24


Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
Speliotes, E.K., Yerges-Armstrong, L.M., Wu, J., Hernaez, R., Kim, L.J., Palmer, C.D., Gudnason, V., Eiriksdottir, G., Garcia, M.E., Launer, L.J., Nalls, M.A., Clark, J.M., Mitchell, B.D., Shuldiner, A.R., Butler, J.L., Tomas, M., Hoffmann, U., Hwang, S.-J., Massaro, J.M., O’Donnell, C.J., Sahani, D.V., Salomaa, V., Schadt, E.E., Schwartz, S.M., Siscovick, D.S., Voight, B.F., Carr, J.J., Feitosa, M.F., Harris, T.B., Fox, C.S., Smith, A.V., Kao, W.H.L., Hirschhorn, J.N. & Borecki, I.B.
Avaldatud: PLoS genetics 7, e1001324


Identification of miR-374a as a prognostic marker for survival in patients with early-stage nonsmall cell lung cancer.
Võsa, U., Vooder, T., Kolde, R., Fischer, K., Välk, K., Tõnisson, N., Roosipuu, R., Vilo, J., Metspalu, A. & Annilo, T.
Avaldatud: Genes, chromosomes & cancer 50, 812-22


Investigating gene expression profile of non-small cell lung cancer.
Vooder, T. & Metspalu, A.
Avaldatud: Cent. Eur. J. Med.


Metagenes associated with survival in NSCLC.
Urgard, E., Vooder, T., Võsa, U., Välk, K., Liu, M., Luo, C., Hoti, F., Roosipuu, R., Annilo, T., Laine, J., Frenz, C.M., Zhang, L. & Metspalu, A.
Avaldatud: Cancer Informatics, 10, 175-183


The Estonian Biobank – the gateway for the stratified medicine.,
Metspalu, A., Leitsalu L., Milani M., Esko T., Allik A., Lilienthal K., Tammesoo M-L., Haller T., Kaasik A-T., Nelis M., Hass M., Fischer K., Krjutskov K., Leego E., Alavere H., Perola M.
Avaldatud: Research in Estonia Present and Future, 283-301


A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (link)
McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, Benhamou S, Bouchardy C, Ahrens W, Merletti F, Richiardi L, Talamini R, Barzan L, Kjaerheim K, Macfarlane GJ, Macfarlane TV, Simonato L, Canova C, Agudo A, Castellsagué X, Lowry R, Conway DI, McKinney PA, Healy CM, Toner ME, Znaor A, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Neto JE, Garrote LF, Boccia S, Cadoni G, Arzani D, Olshan AF, Weissler MC, Funkhouser WK, Luo J, Lubiński J, Trubicka J, Lener M, Oszutowska D, Schwartz SM, Chen C, Fish S, Doody DR, Muscat JE, Lazarus P, Gallagher CJ, Chang SC, Zhang ZF, Wei Q, Sturgis EM, Wang LE, Franceschi S, Herrero R, Kelsey KT, McClean MD, Marsit CJ, Nelson HH, Romkes M, Buch S, Nukui T, Zhong S, Lacko M, Manni JJ, Peters WH, Hung RJ, McLaughlin J, Vatten L, Njølstad I, Goodman GE, Field JK, Liloglou T, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Quirós JR, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Khaw KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Välk K, Vooder T, Metspalu A, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Blanché H, Gut IG, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P.
Avaldatud: PLoS Genet. 2011 Mar;7(3):e1001333. Epub 2011 Mar 17. Erratum in: PLoS Genet. 2011 Apr;7(4).


Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J., Kim, Cameron D. Palmer, Vilmundur Gudnason, Gudny Eiriksdottir, Melissa E. Garcia, Lenore J. Launer, Michael A. Nalls, Jeanne M. Clark, Braxton D. Mitchell, Alan R. Shuldiner, Johannah L. Butler, Marta Tomas, Udo Hoffmann, Shih-Jen Hwang, Joseph M., Massaro, Christopher J. O’Donnell, Dushyant V. Sahani, Veikko Salomaa, Eric E. Schadt, Stephen M. Schwartz, David S. Siscovick, NASH CRN, GIANT Consortium (Reedik Mägi, Tõnu Esko, Helene Alavere, Mari Nelis, Makus Perola, Mari-Liis Tammesoo, Maris Teder-Laving, Andres Metspalu), MAGIC, Investigators", Benjamin F. Voight, J. Jeffrey Carr, Mary F. Feitosa, Tamara B. Harris, Caroline S. Fox, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki., GOLD Consortium"
Avaldatud: PLoS Genetics, March 2011, Volume 7, Issue 3, e1001324


Metagenes associated with survival in NSCLC (link)
Urgard, Egon; Vooder, Tõnu; Võsa, Urmo; Välk, Kristjan; Liu, Mingming; Luo, Cheng; Hoti, Fabian; Roosipuu, Retlav; Annilo, Tarmo; Laine, Jukka; . Frenz, Christopher M; Zhang, Liqing; Metspalu, Andres
Avaldatud: Cancer Informatics 2011:10 175–183
DOI: doi: 10.4137/CIN.S7135


Systems medicine and integrated care to combat chronic noncommunicable diseases. (link)
Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, Agusti A, Brightling C, Cambon-Thomsen A, Cesario A, Abdelhak S, Antonarakis SE, Avignon A, Ballabio A, Baraldi E, Baranov A, Bieber T, Bockaert J, Brahmachari S, Brambilla C, Bringer J, Dauzat M, Ernberg I, Fabbri L, Froguel P, Galas D, Gojobori T, Hunter P, Jorgensen C, Kauffmann F, Kourilsky P, Kowalski ML, Lancet D, Pen CL, Mallet J, Mayosi B, Mercier J, Metspalu A, Nadeau JH, Ninot G, Noble D, Oztürk M, Palkonen S, Préfaut C, Rabe K, Renard E, Roberts RG, Samolinski B, Schünemann HJ, Simon HU, Soares MB, Superti-Furga G, Tegner J, Verjovski-Almeida S, Wellstead P, Wolkenhauer O, Wouters E, Balling R, Brookes AJ, Charron D, Pison C, Chen Z, Hood L, Auffray C.
Avaldatud: Genome Med. 2011 Jul 6;3(7):43.


Comprehensive catalog of European biobanks. (link)
Wichmann HE, Kuhn KA, Waldenberger M, Schmelcher D, Schuffenhauer S, Meitinger T, Wurst SH, Lamla G, Fortier I, Burton PR, Peltonen L, Perola M, Metspalu A, Riegman P, Landegren U, Taussig MJ, Litton JE, Fransson MN, Eder J, Cambon-Thomsen A, Bovenberg J, Dagher G, van Ommen GJ, Griffith M, Yuille M, Zatloukal K.
Avaldatud: Nat Biotechnol. 2011 Sep 8;29(9):795-7
DOI: doi: 10.1038/nbt.1958


Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. (link)
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, Almgren P, Barker DJ, Barnes D, Dennison EM, Eriksson JG, Eriksson P, Eury E, Folkersen L, Fox CS, Frayling TM, Goel A, Gu HF, Horikoshi M, Isomaa B, Jackson AU, Jameson KA, Kajantie E, Kerr-Conte J, Kuulasmaa T, Kuusisto J, Loos RJ, Luan J, Makrilakis K, Manning AK, Martínez-Larrad MT, Narisu N, Nastase Mannila M, Ohrvik J, Osmond C, Pascoe L, Payne F, Sayer AA, Sennblad B, Silveira A, Stancáková A, Stirrups K, Swift AJ, Syvänen AC, Tuomi T, van ''t Hooft FM, Walker M, Weedon MN, Xie W, Zethelius B; DIAGRAM Consortium; GIANT Consortium (incl. Andres Metspalu, Maris Teder-Laving, Mari-Liis Tammesoo, Helene Alavere, Mari Nelis); MuTHER Consortium; CARDIoGRAM Consortium; C4D Consortium, Ongen H, Mälarstig A, Hopewell JC, Saleheen D, Chambers J, Parish S, Danesh J, Kooner J, Ostenson CG, Lind L, Cooper CC, Serrano-Ríos M, Ferrannini E, Forsen TJ, Clarke R, Franzosi MG, Seedorf U, Watkins H, Froguel P, Johnson P, Deloukas P, Collins FS, Laakso M, Dermitzakis ET, Boehnke M, McCarthy MI, Wareham NJ, Groop L, Pattou F, Gloyn AL, Dedoussis GV, Lyssenko V, Meigs JB, Barroso I, Watanabe RM, Ingelsson E, Langenberg C, Hamsten A, Florez JC.
Avaldatud: Diabetes. 2011 Oct;60(10):2624-34. Epub 2011 Aug 26.

 

2010 (33)

CLOCK gene variants associate with sleep duration in two independent populations.
Allebrandt, K.V., Teder-Laving, M., Akyol, M., Pichler, I., Müller-Myhsok, B., Pramstaller, P., Merrow, M., Meitinger, T., Metspalu, A. & Roenneberg, T.
Avaldatud: Biological psychiatry 67, 1040-7


Manifesto for a European anxiety disorders research network.
Baldwin, D.S., Allgulander, C., Altamura, A.C., Angst, J., Bandelow, B., den Boer, J., Boyer, P., Davies, S., Dell’osso, B., Eriksson, E., Fineberg, N., Fredrikson, M., Herran, A., Maron, E., Metspalu, A., Nutt, D., van der Wee, N., Vázquez-Barquero, J.L. & Zohar, J.
Avaldatud: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20, 426-32


Unique spectrum of SPAST variants in Estonian HSP patients: presence of benign missense changes but lack of exonic rearrangements.
Braschinsky, M., Tamm, R., Beetz, C., Sachez-Ferrero, E., Raukas, E., Lüüs, S.-M., Gross-Paju, K., Boillot, C., Canzian, F., Metspalu, A. & Haldre, S.
Avaldatud: BMC neurology 10, 17


Meta-analysis of genome-wide association studies for personality.
de Moor, M.H.M., Costa, P.T., Terracciano, A., Krueger, R.F., de Geus, E.J.C., Toshiko, T., Penninx, B.W.J.H., Esko, T., Madden, P.A.F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J.-J., Distel, M.A., Uda, M., Sanna, S., Spinhoven, P., Hartman, C.A., Sullivan, P., Realo, A., Allik, J., Heath, A.C., Pergadia, M.L., Agrawal, A., Lin, P., Grucza, R., Nutile, T., Ciullo, M., Rujescu, D., Giegling, I., Konte, B., Widen, E., Cousminer, D.L., Eriksson, J.G., Palotie, A., Peltonen, L., Luciano, M., Tenesa, A., Davies, G., Lopez, L.M., Hansell, N.K., Medland, S.E., Ferrucci, L., Schlessinger, D., Montgomery, G.W., Wright, M.J., Aulchenko, Y.S., Janssens, A.C.J.W., Oostra, B.A., Metspalu, A., Abecasis, G.R., Deary, I.J., Räikkönen, K., Bierut, L.J., Martin, N.G., van Duijn, C.M. & Boomsma, D.I.
Avaldatud: Molecular psychiatry


Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
Elks, C.E., Perry, J.R.B., Sulem, P., Chasman, D.I., Franceschini, N., He, C., Lunetta, K.L., Visser, J.A., Byrne, E.M., Cousminer, D.L., Gudbjartsson, D.F., Esko, T., Feenstra, B., Hottenga, J.-J., Koller, D.L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M., McArdle, P.F., Smith, A.V., Stolk, L., van Wingerden, S.H., Zhao, J.H., Albrecht, E., Corre, T., Ingelsson, E., Hayward, C., Magnusson, P.K.E., Smith, E.N., Ulivi, S., Warrington, N.M., Zgaga, L., Alavere, H., Amin, N., Aspelund, T., Bandinelli, S., Barroso, I., Berenson, G.S., Bergmann, S., Blackburn, H., Boerwinkle, E., Buring, J.E., Busonero, F., Campbell, H., Chanock, S.J., Chen, W., Cornelis, M.C., Couper, D., Coviello, A.D., d’ Adamo, P., de Faire, U., de Geus, E.J.C., Deloukas, P., Döring, A., Smith, G.D., Easton, D.F., Eiriksdottir, G., Emilsson, V., Eriksson, J., Ferrucci, L., Folsom, A.R., Foroud, T., Garcia, M., Gasparini, P., Geller, F., Gieger, C., Gudnason, V., Hall, P., Hankinson, S.E., Ferreli, L., Heath, A.C., Hernandez, D.G., Hofman, A., Hu, F.B., Illig, T., Järvelin, M.-R., Johnson, A.D., Karasik, D., Khaw, K.-T., Kiel, D.P., Kilpeläinen, T.O., Kolcic, I., Kraft, P., Launer, L.J., Laven, J.S.E., Li, S., Liu, J., Levy, D., Martin, N.G., McArdle, W.L., Melbye, M., Mooser, V., Murray, J.C., Murray, S.S., Nalls, M.A., Navarro, P., Nelis, M., Ness, A.R., Northstone, K., Oostra, B.A., Peacock, M., Palmer, L.J., Palotie, A., Paré, G., Parker, A.N., Pedersen, N.L., Peltonen, L., Pennell, C.E., Pharoah, P., Polasek, O., Plump, A.S., Pouta, A., Porcu, E., Rafnar, T., Rice, J.P., Ring, S.M., Rivadeneira, F., Rudan, I., Sala, C., Salomaa, V., Sanna, S., Schlessinger, D., Schork, N.J., Scuteri, A., Segrè, A.V., Shuldiner, A.R., Soranzo, N., Sovio, U., Srinivasan, S.R., Strachan, D.P., Tammesoo, M.-L., Tikkanen, E., Toniolo, D., Tsui, K., Tryggvadottir, L., Tyrer, J., Uda, M., van Dam, R.M., van Meurs, J.B.J., Vollenweider, P., Waeber, G., Wareham, N.J., Waterworth, D.M., Weedon, M.N., Wichmann, H.E., Willemsen, G., Wilson, J.F., Wright, A.F., Young, L., Zhai, G., Zhuang, W.V., Bierut, L.J., Boomsma, D.I., Boyd, H.A., Crisponi, L., Demerath, E.W., van Duijn, C.M., Econs, M.J., Harris, T.B., Hunter, D.J., Loos, R.J.F., Metspalu, A., Montgomery, G.W., Ridker, P.M., Spector, T.D., Streeten, E.A., Stefansson, K., Thorsteinsdottir, U., Uitterlinden, A.G., Widen, E., Murabito, J.M., Ong, K.K. & Murray, A.
Avaldatud: Nature genetics 42, 1077-85


Common variants in KCNN3 are associated with lone atrial fibrillation.
Ellinor, P.T., Lunetta, K.L., Glazer, N.L., Pfeufer, A., Alonso, A., Chung, M.K., Sinner, M.F., de Bakker, P.I.W., Mueller, M., Lubitz, S.A., Fox, E., Darbar, D., Smith, N.L., Smith, J.D., Schnabel, R.B., Soliman, E.Z., Rice, K.M., Van Wagoner, D.R., Beckmann, B.-M., van Noord, C., Wang, K., Ehret, G.B., Rotter, J.I., Hazen, S.L., Steinbeck, G., Smith, A.V., Launer, L.J., Harris, T.B., Makino, S., Nelis, M., Milan, D.J., Perz, S., Esko, T., Köttgen, A., Moebus, S., Newton-Cheh, C., Li, M., Möhlenkamp, S., Wang, T.J., Kao, W.H.L., Vasan, R.S., Nöthen, M.M., MacRae, C.A., Stricker, B.H.C., Hofman, A., Uitterlinden, A.G., Levy, D., Boerwinkle, E., Metspalu, A., Topol, E.J., Chakravarti, A., Gudnason, V., Psaty, B.M., Roden, D.M., Meitinger, T., Wichmann, H.-E., Witteman, J.C.M., Barnard, J., Arking, D.E., Benjamin, E.J., Heckbert, S.R. & Kääb, S.
Avaldatud: Nature genetics 42, 240-4


Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies.
Fortier, I., Burton, P.R., Robson, P.J., Ferretti, V., Little, J., L’Heureux, F., Deschênes, M., Knoppers, B.M., Doiron, D., Keers, J.C., Linksted, P., Harris, J.R., Lachance, G., Boileau, C., Pedersen, N.L., Hamilton, C.M., Hveem, K., Borugian, M.J., Gallagher, R.P., McLaughlin, J., Parker, L., Potter, J.D., Gallacher, J., Kaaks, R., Liu, B., Sprosen, T., Vilain, A., Atkinson, S.A., Rengifo, A., Morton, R., Metspalu, A., Wichmann, H.E., Tremblay, M., Chisholm, R.L., Garcia-Montero, A., Hillege, H., Litton, J.-E., Palmer, L.J., Perola, M., Wolffenbuttel, B.H.R., Peltonen, L. & Hudson, T.J.
Avaldatud: International journal of epidemiology 39, 1383-93


Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Mägi, R., Workalemahu, T., White, C.C., Bouatia-Naji, N., Harris, T.B., Berndt, S.I., Ingelsson, E., Willer, C.J., Weedon, M.N., Luan, J., Vedantam, S., Esko, T., Kilpeläinen, T.O., Kutalik, Z., Li, S., Monda, K.L., Dixon, A.L., Holmes, C.C., Kaplan, L.M., Liang, L., Min, J.L., Moffatt, M.F., Molony, C., Nicholson, G., Schadt, E.E., Zondervan, K.T., Feitosa, M.F., Ferreira, T., Allen, H.L., Weyant, R.J., Wheeler, E., Wood, A.R., Estrada, K., Goddard, M.E., Lettre, G., Mangino, M., Nyholt, D.R., Purcell, S., Smith, A.V., Visscher, P.M., Yang, J., McCarroll, S.A., Nemesh, J., Voight, B.F., Absher, D., Amin, N., Aspelund, T., Coin, L., Glazer, N.L., Hayward, C., Heard-Costa, N.L., Hottenga, J.-J., Johansson, A., Johnson, T., Kaakinen, M., Kapur, K., Ketkar, S., Knowles, J.W., Kraft, P., Kraja, A.T., Lamina, C., Leitzmann, M.F., McKnight, B., Morris, A.P., Ong, K.K., Perry, J.R.B., Peters, M.J., Polasek, O., Prokopenko, I., Rayner, N.W., Ripatti, S., Rivadeneira, F., Robertson, N.R., Sanna, S., Sovio, U., Surakka, I., Teumer, A., van Wingerden, S., Vitart, V., Zhao, J.H., Cavalcanti-Proença, C., Chines, P.S., Fisher, E., Kulzer, J.R., Lecoeur, C., Narisu, N., Sandholt, C., Scott, L.J., Silander, K., Stark, K., Tammesoo, M.-L., Teslovich, T.M., Timpson, N.J., Watanabe, R.M., Welch, R., Chasman, D.I., Cooper, M.N., Jansson, J.-O., Kettunen, J., Lawrence, R.W., Pellikka, N., Perola, M., Vandenput, L., Alavere, H., Almgren, P., Atwood, L.D., Bennett, A.J., Biffar, R., Bonnycastle, L.L., Bornstein, S.R., Buchanan, T.A., Campbell, H., Day, I.N.M., Dei, M., Dörr, M., Elliott, P., Erdos, M.R., Eriksson, J.G., Freimer, N.B., Fu, M., Gaget, S., Geus, E.J.C., Gjesing, A.P., Grallert, H., Grässler, J., Groves, C.J., Guiducci, C., Hartikainen, A.-L., Hassanali, N., Havulinna, A.S., Herzig, K.-H., Hicks, A.A., Hui, J., Igl, W., Jousilahti, P., Jula, A., Kajantie, E., Kinnunen, L., Kolcic, I., Koskinen, S., Kovacs, P., Kroemer, H.K., Krzelj, V., Kuusisto, J., Kvaloy, K., Laitinen, J., Lantieri, O., Lathrop, G.M., Lokki, M.-L., Luben, R.N., Ludwig, B., McArdle, W.L., McCarthy, A., Morken, M.A., Nelis, M., Neville, M.J., Paré, G., Parker, A.N., Peden, J.F., Pichler, I., Pietiläinen, K.H., Platou, C.G.P., Pouta, A., Ridderstråle, M., Samani, N.J., Saramies, J., Sinisalo, J., Smit, J.H., Strawbridge, R.J., Stringham, H.M., Swift, A.J., Teder-Laving, M., Thomson, B., Usala, G., van Meurs, J.B.J., van Ommen, G.-J., Vatin, V., Volpato, C.B., Wallaschofski, H., Walters, G.B., Widen, E., Wild, S.H., Willemsen, G., Witte, D.R., Zgaga, L., Zitting, P., Beilby, J.P., James, A.L., Kähönen, M., Lehtimäki, T., Nieminen, M.S., Ohlsson, C., Palmer, L.J., Raitakari, O., Ridker, P.M., Stumvoll, M., Tönjes, A., Viikari, J., Balkau, B., Ben-Shlomo, Y., Bergman, R.N., Boeing, H., Smith, G.D., Ebrahim, S., Froguel, P., Hansen, T., Hengstenberg, C., Hveem, K., Isomaa, B., Jørgensen, T., Karpe, F., Khaw, K.-T., Laakso, M., Lawlor, D.A., Marre, M., Meitinger, T., Metspalu, A., Midthjell, K., Pedersen, O., Salomaa, V., Schwarz, P.E.H., Tuomi, T., Tuomilehto, J., Valle, T.T., Wareham, N.J., Arnold, A.M., Beckmann, J.S., Bergmann, S., Boerwinkle, E., Boomsma, D.I., Caulfield, M.J., Collins, F.S., Eiriksdottir, G., Gudnason, V., Gyllensten, U., Hamsten, A., Hattersley, A.T., Hofman, A., Hu, F.B., Illig, T., Iribarren, C., Jarvelin, M.-R., Kao, W.H.L., Kaprio, J., Launer, L.J., Munroe, P.B., Oostra, B., Penninx, B.W., Pramstaller, P.P., Psaty, B.M., Quertermous, T., Rissanen, A., Rudan, I., Shuldiner, A.R., Soranzo, N., Spector, T.D., Syvanen, A.-C., Uda, M., Uitterlinden, A., Völzke, H., Vollenweider, P., Wilson, J.F., Witteman, J.C., Wright, A.F., Abecasis, G.R., Boehnke, M., Borecki, I.B., Deloukas, P., Frayling, T.M., Groop, L.C., Haritunians, T., Hunter, D.J., Kaplan, R.C., North, K.E., O’Connell, J.R., Peltonen, L., Schlessinger, D., Strachan, D.P., Hirschhorn, J.N., Assimes, T.L., Wichmann, H.-E., Thorsteinsdottir, U., van Duijn, C.M., Stefansson, K., Cupples, L.A., Loos, R.J.F., Barroso, I., McCarthy, M.I., Fox, C.S., Mohlke, K.L. & Lindgren, C.M.
Avaldatud: Nature genetics 42, 949-60


MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.
Jagomägi, T., Nikopensius, T., Krjutskov, K., Tammekivi, V., Viltrop, T., Saag, M. & Metspalu, A.
Avaldatud: European journal of oral sciences 118, 213-20


Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with cardiovascular traits.
Kepp, K., Org, E., Sõber, S., Kelgo, P., Viigimaa, M., Veldre, G., Tõnisson, N., Juhanson, P., Putku, M., Kindmark, A., Kozich, V. & Laan, M.
Avaldatud: BMC medical genetics 11, 15


Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Lango Allen, H., Estrada, K., Lettre, G., Berndt, S.I., Weedon, M.N., Rivadeneira, F., Willer, C.J., Jackson, A.U., Vedantam, S., Raychaudhuri, S., Ferreira, T., Wood, A.R., Weyant, R.J., Segrè, A.V., Speliotes, E.K., Wheeler, E., Soranzo, N., Park, J.-H., Yang, J., Gudbjartsson, D., Heard-Costa, N.L., Randall, J.C., Qi, L., Vernon Smith, A., Mägi, R., Pastinen, T., Liang, L., Heid, I.M., Luan, J., Thorleifsson, G., Winkler, T.W., Goddard, M.E., Sin Lo, K., Palmer, C., Workalemahu, T., Aulchenko, Y.S., Johansson, A., Zillikens, M.C., Feitosa, M.F., Esko, T., Johnson, T., Ketkar, S., Kraft, P., Mangino, M., Prokopenko, I., Absher, D., Albrecht, E., Ernst, F., Glazer, N.L., Hayward, C., Hottenga, J.-J., Jacobs, K.B., Knowles, J.W., Kutalik, Z., Monda, K.L., Polasek, O., Preuss, M., Rayner, N.W., Robertson, N.R., Steinthorsdottir, V., Tyrer, J.P., Voight, B.F., Wiklund, F., Xu, J., Zhao, J.H., Nyholt, D.R., Pellikka, N., Perola, M., Perry, J.R.B., Surakka, I., Tammesoo, M.-L., Altmaier, E.L., Amin, N., Aspelund, T., Bhangale, T., Boucher, G., Chasman, D.I., Chen, C., Coin, L., Cooper, M.N., Dixon, A.L., Gibson, Q., Grundberg, E., Hao, K., Juhani Junttila, M., Kaplan, L.M., Kettunen, J., König, I.R., Kwan, T., Lawrence, R.W., Levinson, D.F., Lorentzon, M., McKnight, B., Morris, A.P., Müller, M., Suh Ngwa, J., Purcell, S., Rafelt, S., Salem, R.M., Salvi, E., Sanna, S., Shi, J., Sovio, U., Thompson, J.R., Turchin, M.C., Vandenput, L., Verlaan, D.J., Vitart, V., White, C.C., Ziegler, A., Almgren, P., Balmforth, A.J., Campbell, H., Citterio, L., De Grandi, A., Dominiczak, A., Duan, J., Elliott, P., Elosua, R., Eriksson, J.G., Freimer, N.B., Geus, E.J.C., Glorioso, N., Haiqing, S., Hartikainen, A.-L., Havulinna, A.S., Hicks, A.A., Hui, J., Igl, W., Illig, T., Jula, A., Kajantie, E., Kilpeläinen, T.O., Koiranen, M., Kolcic, I., Koskinen, S., Kovacs, P., Laitinen, J., Liu, J., Lokki, M.-L., Marusic, A., Maschio, A., Meitinger, T., Mulas, A., Paré, G., Parker, A.N., Peden, J.F., Petersmann, A., Pichler, I., Pietiläinen, K.H., Pouta, A., Ridderstråle, M., Rotter, J.I., Sambrook, J.G., Sanders, A.R., Schmidt, C.O., Sinisalo, J., Smit, J.H., Stringham, H.M., Bragi Walters, G., Widen, E., Wild, S.H., Willemsen, G., Zagato, L., Zgaga, L., Zitting, P., Alavere, H., Farrall, M., McArdle, W.L., Nelis, M., Peters, M.J., Ripatti, S., van Meurs, J.B.J., Aben, K.K., Ardlie, K.G., Beckmann, J.S., Beilby, J.P., Bergman, R.N., Bergmann, S., Collins, F.S., Cusi, D., den Heijer, M., Eiriksdottir, G., Gejman, P.V., Hall, A.S., Hamsten, A., Huikuri, H.V., Iribarren, C., Kähönen, M., Kaprio, J., Kathiresan, S., Kiemeney, L., Kocher, T., Launer, L.J., Lehtimäki, T., Melander, O., Mosley, T.H., Musk, A.W., Nieminen, M.S., O’Donnell, C.J., Ohlsson, C., Oostra, B., Palmer, L.J., Raitakari, O., Ridker, P.M., Rioux, J.D., Rissanen, A., Rivolta, C., Schunkert, H., Shuldiner, A.R., Siscovick, D.S., Stumvoll, M., Tönjes, A., Tuomilehto, J., van Ommen, G.-J., Viikari, J., Heath, A.C., Martin, N.G., Montgomery, G.W., Province, M.A., Kayser, M., Arnold, A.M., Atwood, L.D., Boerwinkle, E., Chanock, S.J., Deloukas, P., Gieger, C., Grönberg, H., Hall, P., Hattersley, A.T., Hengstenberg, C., Hoffman, W., Lathrop, G.M., Salomaa, V., Schreiber, S., Uda, M., Waterworth, D., Wright, A.F., Assimes, T.L., Barroso, I., Hofman, A., Mohlke, K.L., Boomsma, D.I., Caulfield, M.J., Cupples, L.A., Erdmann, J., Fox, C.S., Gudnason, V., Gyllensten, U., Harris, T.B., Hayes, R.B., Jarvelin, M.-R., Mooser, V., Munroe, P.B., Ouwehand, W.H., Penninx, B.W., Pramstaller, P.P., Quertermous, T., Rudan, I., Samani, N.J., Spector, T.D., Völzke, H., Watkins, H., Wilson, J.F., Groop, L.C., Haritunians, T., Hu, F.B., Kaplan, R.C., Metspalu, A., North, K.E., Schlessinger, D., Wareham, N.J., Hunter, D.J., O’Connell, J.R., Strachan, D.P., Wichmann, H.-E., Borecki, I.B., van Duijn, C.M., Schadt, E.E., Thorsteinsdottir, U., Peltonen, L., Uitterlinden, A.G., Visscher, P.M., Chatterjee, N., Loos, R.J.F., Boehnke, M., McCarthy, M.I., Ingelsson, E., Lindgren, C.M., Abecasis, G.R., Stefansson, K., Frayling, T.M. & Hirschhorn, J.N.
Avaldatud: Nature 467, 832-8


Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals.
Lips, E.H., Gaborieau, V., McKay, J.D., Chabrier, A., Hung, R.J., Boffetta, P., Hashibe, M., Zaridze, D., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Field, J.K., Liloglou, T., Xinarianos, G., McLaughlin, J., Liu, G., Skorpen, F., Elvestad, M.B., Hveem, K., Vatten, L., Study, E., Benhamou, S., Lagiou, P., Holcátová, I., Merletti, F., Kjaerheim, K., Agudo, A., Castellsagué, X., Macfarlane, T.V., Barzan, L., Canova, C., Lowry, R., Conway, D.I., Znaor, A., Healy, C., Curado, M.P., Koifman, S., Eluf-Neto, J., Matos, E., Menezes, A., Fernandez, L., Metspalu, A., Heath, S., Lathrop, M. & Brennan, P.
Avaldatud: International journal of epidemiology 39, 563-77


A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia.
Männik, K., Parkel, S., Palta, P., Zilina, O., Puusepp, H., Esko, T., Mägi, R., Nõukas, M., Veidenberg, A., Nelis, M., Metspalu, A., Remm, M., Ounap, K. & Kurg, A.
Avaldatud: European journal of medical genetics 54, 136-43


Advances in molecular genetics of panic disorder.
Maron, E., Hettema, J.M. & Shlik, J.
Avaldatud: Molecular psychiatry 15, 681-701


Peripheral gene expression profiling of CCK-4-induced panic in healthy subjects.
Maron, E., Kallassalu, K., Tammiste, A., Kolde, R., Vilo, J., Tõru, I., Vasar, V., Shlik, J. & Metspalu, A.
Avaldatud: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 153B, 269-74


Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patients.
Nikopensius, T., Birnbaum, S., Ludwig, K.U., Jagomägi, T., Saag, M., Herms, S., Knapp, M., Hoffmann, P., Nöthen, M.M., Metspalu, A. & Mangold, E.
Avaldatud: European journal of oral sciences 118, 317-9


Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.
Nikopensius, T., Jagomägi, T., Krjutskov, K., Tammekivi, V., Saag, M., Prane, I., Piekuse, L., Akota, I., Barkane, B., Krumina, A., Ambrozaityte, L., Matuleviciene, A., Kucinskiene, Z.A., Lace, B., Kucinskas, V. & Metspalu, A.
Avaldatud: Birth defects research. Part A, Clinical and molecular teratology 88, 748-56


HGV2009 meeting: bigger and better studies provide more answers and more questions.
Reekie, K., Metspalu, A., Chanock, S.J., Liu, E.T., Mardis, E.R., Scherer, S.W., Kwok, P.-Y. & Brookes, A.J.
Avaldatud: Human mutation 31, 886-8


Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis.
Saare, M., Lamp, M., Kaart, T., Karro, H., Kadastik, U., Metspalu, A., Peters, M. & Salumets, A.
Avaldatud: Fertility and sterility 94, 1560-3


Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Allen, H.L., Lindgren, C.M., Luan, J., Mägi, R., Randall, J.C., Vedantam, S., Winkler, T.W., Qi, L., Workalemahu, T., Heid, I.M., Steinthorsdottir, V., Stringham, H.M., Weedon, M.N., Wheeler, E., Wood, A.R., Ferreira, T., Weyant, R.J., Segrè, A.V., Estrada, K., Liang, L., Nemesh, J., Park, J.-H., Gustafsson, S., Kilpeläinen, T.O., Yang, J., Bouatia-Naji, N., Esko, T., Feitosa, M.F., Kutalik, Z., Mangino, M., Raychaudhuri, S., Scherag, A., Smith, A.V., Welch, R., Zhao, J.H., Aben, K.K., Absher, D.M., Amin, N., Dixon, A.L., Fisher, E., Glazer, N.L., Goddard, M.E., Heard-Costa, N.L., Hoesel, V., Hottenga, J.-J., Johansson, A., Johnson, T., Ketkar, S., Lamina, C., Li, S., Moffatt, M.F., Myers, R.H., Narisu, N., Perry, J.R.B., Peters, M.J., Preuss, M., Ripatti, S., Rivadeneira, F., Sandholt, C., Scott, L.J., Timpson, N.J., Tyrer, J.P., van Wingerden, S., Watanabe, R.M., White, C.C., Wiklund, F., Barlassina, C., Chasman, D.I., Cooper, M.N., Jansson, J.-O., Lawrence, R.W., Pellikka, N., Prokopenko, I., Shi, J., Thiering, E., Alavere, H., Alibrandi, M.T.S., Almgren, P., Arnold, A.M., Aspelund, T., Atwood, L.D., Balkau, B., Balmforth, A.J., Bennett, A.J., Ben-Shlomo, Y., Bergman, R.N., Bergmann, S., Biebermann, H., Blakemore, A.I.F., Boes, T., Bonnycastle, L.L., Bornstein, S.R., Brown, M.J., Buchanan, T.A., Busonero, F., Campbell, H., Cappuccio, F.P., Cavalcanti-Proença, C., Chen, Y.-D.I., Chen, C.-M., Chines, P.S., Clarke, R., Coin, L., Connell, J., Day, I.N.M., Heijer, M. den, Duan, J., Ebrahim, S., Elliott, P., Elosua, R., Eiriksdottir, G., Erdos, M.R., Eriksson, J.G., Facheris, M.F., Felix, S.B., Fischer-Posovszky, P., Folsom, A.R., Friedrich, N., Freimer, N.B., Fu, M., Gaget, S., Gejman, P.V., Geus, E.J.C., Gieger, C., Gjesing, A.P., Goel, A., Goyette, P., Grallert, H., Grässler, J., Greenawalt, D.M., Groves, C.J., Gudnason, V., Guiducci, C., Hartikainen, A.-L., Hassanali, N., Hall, A.S., Havulinna, A.S., Hayward, C., Heath, A.C., Hengstenberg, C., Hicks, A.A., Hinney, A., Hofman, A., Homuth, G., Hui, J., Igl, W., Iribarren, C., Isomaa, B., Jacobs, K.B., Jarick, I., Jewell, E., John, U., Jørgensen, T., Jousilahti, P., Jula, A., Kaakinen, M., Kajantie, E., Kaplan, L.M., Kathiresan, S., Kettunen, J., Kinnunen, L., Knowles, J.W., Kolcic, I., König, I.R., Koskinen, S., Kovacs, P., Kuusisto, J., Kraft, P., Kvaløy, K., Laitinen, J., Lantieri, O., Lanzani, C., Launer, L.J., Lecoeur, C., Lehtimäki, T., Lettre, G., Liu, J., Lokki, M.-L., Lorentzon, M., Luben, R.N., Ludwig, B., Manunta, P., Marek, D., Marre, M., Martin, N.G., McArdle, W.L., McCarthy, A., McKnight, B., Meitinger, T., Melander, O., Meyre, D., Midthjell, K., Montgomery, G.W., Morken, M.A., Morris, A.P., Mulic, R., Ngwa, J.S., Nelis, M., Neville, M.J., Nyholt, D.R., O’Donnell, C.J., O’Rahilly, S., Ong, K.K., Oostra, B., Paré, G., Parker, A.N., Perola, M., Pichler, I., Pietiläinen, K.H., Platou, C.G.P., Polasek, O., Pouta, A., Rafelt, S., Raitakari, O., Rayner, N.W., Ridderstråle, M., Rief, W., Ruokonen, A., Robertson, N.R., Rzehak, P., Salomaa, V., Sanders, A.R., Sandhu, M.S., Sanna, S., Saramies, J., Savolainen, M.J., Scherag, S., Schipf, S., Schreiber, S., Schunkert, H., Silander, K., Sinisalo, J., Siscovick, D.S., Smit, J.H., Soranzo, N., Sovio, U., Stephens, J., Surakka, I., Swift, A.J., Tammesoo, M.-L., Tardif, J.-C., Teder-Laving, M., Teslovich, T.M., Thompson, J.R., Thomson, B., Tönjes, A., Tuomi, T., van Meurs, J.B.J., van Ommen, G.-J., Vatin, V., Viikari, J., Visvikis-Siest, S., Vitart, V., Vogel, C.I.G., Voight, B.F., Waite, L.L., Wallaschofski, H., Walters, G.B., Widen, E., Wiegand, S., Wild, S.H., Willemsen, G., Witte, D.R., Witteman, J.C., Xu, J., Zhang, Q., Zgaga, L., Ziegler, A., Zitting, P., Beilby, J.P., Farooqi, I.S., Hebebrand, J., Huikuri, H.V., James, A.L., Kähönen, M., Levinson, D.F., Macciardi, F., Nieminen, M.S., Ohlsson, C., Palmer, L.J., Ridker, P.M., Stumvoll, M., Beckmann, J.S., Boeing, H., Boerwinkle, E., Boomsma, D.I., Caulfield, M.J., Chanock, S.J., Collins, F.S., Cupples, L.A., Smith, G.D., Erdmann, J., Froguel, P., Grönberg, H., Gyllensten, U., Hall, P., Hansen, T., Harris, T.B., Hattersley, A.T., Hayes, R.B., Heinrich, J., Hu, F.B., Hveem, K., Illig, T., Jarvelin, M.-R., Kaprio, J., Karpe, F., Khaw, K.-T., Kiemeney, L.A., Krude, H., Laakso, M., Lawlor, D.A., Metspalu, A., Munroe, P.B., Ouwehand, W.H., Pedersen, O., Penninx, B.W., Peters, A., Pramstaller, P.P., Quertermous, T., Reinehr, T., Rissanen, A., Rudan, I., Samani, N.J., Schwarz, P.E.H., Shuldiner, A.R., Spector, T.D., Tuomilehto, J., Uda, M., Uitterlinden, A., Valle, T.T., Wabitsch, M., Waeber, G., Wareham, N.J., Watkins, H., Wilson, J.F., Wright, A.F., Zillikens, M.C., Chatterjee, N., McCarroll, S.A., Purcell, S., Schadt, E.E., Visscher, P.M., Assimes, T.L., Borecki, I.B., Deloukas, P., Fox, C.S., Groop, L.C., Haritunians, T., Hunter, D.J., Kaplan, R.C., Mohlke, K.L., O’Connell, J.R., Peltonen, L., Schlessinger, D., Strachan, D.P., van Duijn, C.M., Wichmann, H.-E., Frayling, T.M., Thorsteinsdottir, U., Abecasis, G.R., Barroso, I., Boehnke, M., Stefansson, K., North, K.E., McCarthy, M.I., Hirschhorn, J.N., Ingelsson, E. & Loos, R.J.F.
Avaldatud: Nature genetics 42, 937-48


Novel human pathological mutations. Gene symbol: SPAST. Disease: Hereditary spastic paraplegia.
Tamm, R.
Avaldatud: Human genetics 127, 112


Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study.
Theodoraki, E.V., Nikopensius, T., Suhorutsenko, J., Peppes, V., Fili, P., Kolovou, G., Papamikos, V., Richter, D., Zakopoulos, N., Krjutskov, K., Metspalu, A. & Dedoussis, G.V.
Avaldatud: BMC medical genetics 11, 28


Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
Thorgeirsson, T.E., Gudbjartsson, D.F., Surakka, I., Vink, J.M., Amin, N., Geller, F., Sulem, P., Rafnar, T., Esko, T., Walter, S., Gieger, C., Rawal, R., Mangino, M., Prokopenko, I., Mägi, R., Keskitalo, K., Gudjonsdottir, I.H., Gretarsdottir, S., Stefansson, H., Thompson, J.R., Aulchenko, Y.S., Nelis, M., Aben, K.K., den Heijer, M., Dirksen, A., Ashraf, H., Soranzo, N., Valdes, A.M., Steves, C., Uitterlinden, A.G., Hofman, A., Tönjes, A., Kovacs, P., Hottenga, J.J., Willemsen, G., Vogelzangs, N., Döring, A., Dahmen, N., Nitz, B., Pergadia, M.L., Saez, B., De Diego, V., Lezcano, V., Garcia-Prats, M.D., Ripatti, S., Perola, M., Kettunen, J., Hartikainen, A.-L., Pouta, A., Laitinen, J., Isohanni, M., Huei-Yi, S., Allen, M., Krestyaninova, M., Hall, A.S., Jones, G.T., van Rij, A.M., Mueller, T., Dieplinger, B., Haltmayer, M., Jonsson, S., Matthiasson, S.E., Oskarsson, H., Tyrfingsson, T., Kiemeney, L.A., Mayordomo, J.I., Lindholt, J.S., Pedersen, J.H., Franklin, W.A., Wolf, H., Montgomery, G.W., Heath, A.C., Martin, N.G., Madden, P.A.F., Giegling, I., Rujescu, D., Järvelin, M.-R., Salomaa, V., Stumvoll, M., Spector, T.D., Wichmann, H.-E., Metspalu, A., Samani, N.J., Penninx, B.W., Oostra, B.A., Boomsma, D.I., Tiemeier, H., van Duijn, C.M., Kaprio, J., Gulcher, J.R., McCarthy, M.I., Peltonen, L., Thorsteinsdottir, U. & Stefansson, K.
Avaldatud: Nature genetics 42, 448-53


Gene expression profiles of non-small cell lung cancer: survival prediction and new biomarkers.
Välk, K., Vooder, T., Kolde, R., Reintam, M.-A., Petzold, C., Vilo, J. & Metspalu, A.
Avaldatud: Oncology 79, 283-92


Comparison of DNA extraction methods for multiplex polymerase chain reaction.
Viltrop, T., Krjutskov, K., Palta, P. & Metspalu, A.
Avaldatud: Analytical biochemistry 398, 260-2


Gene Expression-Based Approaches in Differentiation of Metastases and Second Primary Tumour.
Vooder, T., Välk, K., Kolde, R., Roosipuu, R., Vilo, J. & Metspalu, A.
Avaldatud: Case reports in oncology 3, 255-261


A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.
Walters, R.G., Jacquemont, S., Valsesia, A., de Smith, A.J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., Delobel, B., Stutzmann, F., El-Sayed Moustafa, J.S., Chèvre, J.-C., Lecoeur, C., Vatin, V., Bouquillon, S., Buxton, J.L., Boute, O., Holder-Espinasse, M., Cuisset, J.-M., Lemaitre, M.-P., Ambresin, A.-E., Brioschi, A., Gaillard, M., Giusti, V., Fellmann, F., Ferrarini, A., Hadjikhani, N., Campion, D., Guilmatre, A., Goldenberg, A., Calmels, N., Mandel, J.-L., Le Caignec, C., David, A., Isidor, B., Cordier, M.-P., Dupuis-Girod, S., Labalme, A., Sanlaville, D., Béri-Dexheimer, M., Jonveaux, P., Leheup, B., Ounap, K., Bochukova, E.G., Henning, E., Keogh, J., Ellis, R.J., Macdermot, K.D., van Haelst, M.M., Vincent-Delorme, C., Plessis, G., Touraine, R., Philippe, A., Malan, V., Mathieu-Dramard, M., Chiesa, J., Blaumeiser, B., Kooy, R.F., Caiazzo, R., Pigeyre, M., Balkau, B., Sladek, R., Bergmann, S., Mooser, V., Waterworth, D., Reymond, A., Vollenweider, P., Waeber, G., Kurg, A., Palta, P., Esko, T., Metspalu, A., Nelis, M., Elliott, P., Hartikainen, A.-L., McCarthy, M.I., Peltonen, L., Carlsson, L., Jacobson, P., Sjöström, L., Huang, N., Hurles, M.E., O’Rahilly, S., Farooqi, I.S., Männik, K., Jarvelin, M.-R., Pattou, F., Meyre, D., Walley, A.J., Coin, L.J.M., Blakemore, A.I.F., Froguel, P. & Beckmann, J.S.
Avaldatud: Nature 463, 671-5


Variance determines self-observer agreement on the Big Five personality traits.
Allik, J., Realo, A., Mõttus, R., Esko, T., Pullat, J. & Metspalu, A.
Avaldatud: Journal of Research in Personality 44, 4, 421-426


Hereditaarset spastilist parapleegiat süsteemselt käsitlenud uuring Eestis tõi esile uusi andmeid.
Braschinsky, M., Rannikmäe, K., Tamm, R., Metspalu, A., Gross-Paju, K. & Haldre, S.
Avaldatud: Eesti Arst, 89(3), 165-170


Gene Expression Profiles of Non-Small Cell Lung Cancer: Survival Prediction and New Biomarkers
Kristjan Välk, Tõnu Vooder, Raivo Kolde, Mari-Ann Reintam, Cathleen Petzold, Jaak Vilo, Andres Metspalu
Avaldatud: Oncology 2010;79:283–292


A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
Walters RG, Jacquemont S, Valsesia A, de Smith AJ, Martinet D, Andersson J, Falchi M, Chen F, Andrieux J, Lobbens S, Delobel B, Stutzmann F, El-Sayed Moustafa JS, Chèvre JC, Lecoeur C, Vatin V, Bouquillon S, Buxton JL, Boute O, Holder-Espinasse M, Cuisset JM, Lemaitre MP, Ambresin AE, Brioschi A, Gaillard M, Giusti V, Fellmann F, Ferrarini A, Hadjikhani N, Campion D, Guilmatre A, Goldenberg A, Calmels N, Mandel JL, Le Caignec C, David A, Isidor B, Cordier MP, Dupuis-Girod S, Labalme A, Sanlaville D, Béri-Dexheimer M, Jonveaux P, Leheup B, Ounap K, Bochukova EG, Henning E, Keogh J, Ellis RJ, Macdermot KD, van Haelst MM, Vincent-Delorme C, Plessis G, Touraine R, Philippe A, Malan V, Mathieu-Dramard M, Chiesa J, Blaumeiser B, Kooy RF, Caiazzo R, Pigeyre M, Balkau B, Sladek R, Bergmann S, Mooser V, Waterworth D, Reymond A, Vollenweider P, Waeber G, Kurg A, Palta P, Esko T, Metspalu A, Nelis M, Elliott P, Hartikainen AL, McCarthy MI, Peltonen L, Carlsson L, Jacobson P, Sjöström L, Huang N, Hurles ME, O''Rahilly S, Farooqi IS, Männik K, Jarvelin MR, Pattou F, Meyre D, Walley AJ, Coin LJ, Blakemore AI, Froguel P, Beckmann JS.
Avaldatud: Nature. 2010 Feb 4;463(7281):671-5.
DOI: 10.1038/nature08727


Meta-analysis of sex-specific genome-wide association studies
Magi R, Lindgren CM, Morris AP.
Avaldatud: Genet Epidemiol. 2010 Dec;34(8):846-53
DOI: 10.1002/gepi.20540


Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O''Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, Sõber S, Parsa A, Luan J, Arora P, Dehghan A, Zhang F, Lucas G, Hicks AA, Jackson AU, Peden JF, Tanaka T, Wild SH, Rudan I, Igl W, Milaneschi Y, Parker AN, Fava C, Chambers JC, Fox ER, Kumari M, Go MJ, van der Harst P, Kao WH, Sjögren M, Vinay DG, Alexander M, Tabara Y, Shaw-Hawkins S, Whincup PH, Liu Y, Shi G, Kuusisto J, Tayo B, Seielstad M, Sim X, Nguyen KD, Lehtimäki T, Matullo G, Wu Y, Gaunt TR, Onland-Moret NC, Cooper MN, Platou CG, Org E, Hardy R, Dahgam S, Palmen J, Vitart V, Braund PS, Kuznetsova T, Uiterwaal CS, Adeyemo A, Palmas W, Campbell H, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer ND; CARDIoGRAM consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen consortium; CHARGE-HF consortium, Aspelund T, Garcia M, Chang YP, O''Connell JR, Steinle NI, Grobbee DE, Arking DE, Kardia SL, Morrison AC, Hernandez D, Najjar S, McArdle WL, Hadley D, Brown MJ, Connell JM, Hingorani AD, Day IN, Lawlor DA, Beilby JP, Lawrence RW, Clarke R, Hopewell JC, Ongen H, Dreisbach AW, Li Y, Young JH, Bis JC, Kähönen M, Viikari J, Adair LS, Lee NR, Chen MH, Olden M, Pattaro C, Bolton JA, Köttgen A, Bergmann S, Mooser V, Chaturvedi N, Frayling TM, Islam M, Jafar TH, Erdmann J, Kulkarni SR, Bornstein SR, Grässler J, Groop L, Voight BF, Kettunen J, Howard P, Taylor A, Guarrera S, Ricceri F, Emilsson V, Plump A, Barroso I, Khaw KT, Weder AB, Hunt SC, Sun YV, Bergman RN, Collins FS, Bonnycastle LL, Scott LJ, Stringham HM, Peltonen L, Perola M, Vartiainen E, Brand SM, Staessen JA, Wang TJ, Burton PR, Soler Artigas M, Dong Y, Snieder H, Wang X, Zhu H, Lohman KK, Rudock ME, Heckbert SR, Smith NL, Wiggins KL, Doumatey A, Shriner D, Veldre G, Viigimaa M, Kinra S, Prabhakaran D, Tripathy V, Langefeld CD, Rosengren A, Thelle DS, Corsi AM, Singleton A, Forrester T, Hilton G, McKenzie CA, Salako T, Iwai N, Kita Y, Ogihara T, Ohkubo T, Okamura T, Ueshima H, Umemura S, Eyheramendy S, Meitinger T, Wichmann HE, Cho YS, Kim HL, Lee JY, Scott J, Sehmi JS, Zhang W, Hedblad B, Nilsson P, Smith GD, Wong A, Narisu N, Stančáková A, Raffel LJ, Yao J, Kathiresan S, O''Donnell CJ, Schwartz SM, Ikram MA, Longstreth WT Jr, Mosley TH, Seshadri S, Shrine NR, Wain LV, Morken MA, Swift AJ, Laitinen J, Prokopenko I, Zitting P, Cooper JA, Humphries SE, Danesh J, Rasheed A, Goel A, Hamsten A, Watkins H, Bakker SJ, van Gilst WH, Janipalli CS, Mani KR, Yajnik CS, Hofman A, Mattace-Raso FU, Oostra BA, Demirkan A, Isaacs A, Rivadeneira F, Lakatta EG, Orru M, Scuteri A, Ala-Korpela M, Kangas AJ, Lyytikäinen LP, Soininen P, Tukiainen T, Würtz P, Ong RT, Dörr M, Kroemer HK, Völker U, Völzke H, Galan P, Hercberg S, Lathrop M, Zelenika D, Deloukas P, Mangino M, Spector TD, Zhai G, Meschia JF, Nalls MA, Sharma P, Terzic J, Kumar MV, Denniff M, Zukowska-Szczechowska E, Wagenknecht LE, Fowkes FG, Charchar FJ, Schwarz PE, Hayward C, Guo X, Rotimi C, Bots ML, Brand E, Samani NJ, Polasek O, Talmud PJ, Nyberg F, Kuh D, Laan M, Hveem K, Palmer LJ, van der Schouw YT, Casas JP, Mohlke KL, Vineis P, Raitakari O, Ganesh SK, Wong TY, Tai ES, Cooper RS, Laakso M, Rao DC, Harris TB, Morris RW, Dominiczak AF, Kivimaki M, Marmot MG, Miki T, Saleheen D, Chandak GR, Coresh J, Navis G, Salomaa V, Han BG, Zhu X, Kooner JS, Melander O, Ridker PM, Bandinelli S, Gyllensten UB, Wright AF, Wilson JF, Ferrucci L, Farrall M, Tuomilehto J, Pramstaller PP, Elosua R, Soranzo N, Sijbrands EJ, Altshuler D, Loos RJ, Shuldiner AR, Gieger C, Meneton P, Uitterlinden AG, Wareham NJ, Gudnason V, Rotter JI, Rettig R, Uda M, Strachan DP, Witteman JC, Hartikainen AL, Beckmann JS, Boerwinkle E, Vasan RS, Boehnke M, Larson MG, Järvelin MR, Psaty BM, Abecasis GR, Chakravarti A, Elliott P, van Duijn CM, Newton-Cheh C, Levy D, Caulfield MJ, Johnson T.
Avaldatud: Nature. 2011 Sep 11;478(7367):103-9
DOI: doi: 10.1038/nature10405

 

2009 (10)

Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Canova, C., Hashibe, M., Simonato, L., Nelis, M., Metspalu, A., Lagiou, P., Trichopoulos, D., Ahrens, W., Pigeot, I., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Macfarlane, G.J., Macfarlane, T.V., Holcátová, I., Bencko, V., Benhamou, S., Bouchardy, C., Kjaerheim, K., Lowry, R., Agudo, A., Castellsagué, X., Conway, D.I., McKinney, P.A., Znaor, A., McCartan, B.E., Healy, C.M., Marron, M. & Brennan, P.
Avaldatud: Cancer research 69, 2956-65


Analysis of allele and haplotype diversity across 25 genomic regions in three Eastern European populations.
Khrunin, A., Mihailov, E., Nikopensius, T., Krjutskov, K., Limborska, S. & Metspalu, A.
Avaldatud: Human heredity 68, 35-44


Evaluation of the 124-plex SNP typing microarray for forensic testing.
Krjutskov, K., Viltrop, T., Palta, P., Metspalu, E., Tamm, E., Suvi, S., Sak, K., Merilo, A., Sork, H., Teek, R., Nikopensius, T., Kivisild, T. & Metspalu, A.
Avaldatud: Forensic science international. Genetics 4, 43-8


Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.
Kuningas, M., May, L., Tamm, R., van Bodegom, D., van den Biggelaar, A.H.J., Meij, J.J., Frölich, M., Ziem, J.B., Suchiman, H.E.D., Metspalu, A., Slagboom, P.E. & Westendorp, R.G.J.
Avaldatud: PloS one 4, e7795


Alcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection.
Lagiou, P., Georgila, C., Minaki, P., Ahrens, W., Pohlabeln, H., Benhamou, S., Bouchardy, C., Slamova, A., Schejbalova, M., Merletti, F., Richiardi, L., Kjaerheim, K., Agudo, A., Castellsague, X., Macfarlane, T.V., Macfarlane, G.J., Talamini, R., Barzan, L., Canova, C., Simonato, L., Lowry, R., Conway, D.I., McKinney, P.A., Znaor, A., McCartan, B.E., Healy, C., Nelis, M., Metspalu, A., Marron, M., Hashibe, M. & Brennan, P.J.
Avaldatud: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 18, 76-84


A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
Landi, M.T., Chatterjee, N., Yu, K., Goldin, L.R., Goldstein, A.M., Rotunno, M., Mirabello, L., Jacobs, K., Wheeler, W., Yeager, M., Bergen, A.W., Li, Q., Consonni, D., Pesatori, A.C., Wacholder, S., Thun, M., Diver, R., Oken, M., Virtamo, J., Albanes, D., Wang, Z., Burdette, L., Doheny, K.F., Pugh, E.W., Laurie, C., Brennan, P., Hung, R., Gaborieau, V., McKay, J.D., Lathrop, M., McLaughlin, J., Wang, Y., Tsao, M.-S., Spitz, M.R., Wang, Y., Krokan, H., Vatten, L., Skorpen, F., Arnesen, E., Benhamou, S., Bouchard, C., Metspalu, A., Metsapalu, A., Vooder, T., Nelis, M., Välk, K., Field, J.K., Chen, C., Goodman, G., Sulem, P., Thorleifsson, G., Rafnar, T., Eisen, T., Sauter, W., Rosenberger, A., Bickeböller, H., Risch, A., Chang-Claude, J., Wichmann, H.E., Stefansson, K., Houlston, R., Amos, C.I., Fraumeni, J.F., Savage, S.A., Bertazzi, P.A., Tucker, M.A., Chanock, S. & Caporaso, N.E.
Avaldatud: American journal of human genetics 85, 679-91


Serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression.
Maron, E., Tammiste, A., Kallassalu, K., Eller, T., Vasar, V., Nutt, D.J. & Metspalu, A.
Avaldatud: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 19, 451-6


Genetic structure of Europeans: a view from the North-East.
Nelis, M., Esko, T., Mägi, R., Zimprich, F., Zimprich, A., Toncheva, D., Karachanak, S., Piskácková, T., Balascák, I., Peltonen, L., Jakkula, E., Rehnström, K., Lathrop, M., Heath, S., Galan, P., Schreiber, S., Meitinger, T., Pfeufer, A., Wichmann, H.-E., Melegh, B., Polgár, N., Toniolo, D., Gasparini, P., D’Adamo, P., Klovins, J., Nikitina-Zake, L., Kucinskas, V., Kasnauskiene, J., Lubinski, J., Debniak, T., Limborska, S., Khrunin, A., Estivill, X., Rabionet, R., Marsal, S., Julià, A., Antonarakis, S.E., Deutsch, S., Borel, C., Attar, H., Gagnebin, M., Macek, M., Krawczak, M., Remm, M. & Metspalu, A.
Avaldatud: PloS one 4, e5472


Replication of novel susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 in Estonian and Lithuanian patients.
Nikopensius, T., Ambrozaityte, L., Ludwig, K.U., Birnbaum, S., Jagomägi, T., Saag, M., Matuleviciene, A., Linkeviciene, L., Herms, S., Knapp, M., Hoffmann, P., Nöthen, M.M., Kucinskas, V., Metspalu, A. & Mangold, E.
Avaldatud: American journal of medical genetics. Part A 149A, 2551-3


ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study.
Theodoraki, E.V., Nikopensius, T., Suhorutsenko, J., Papamikos, V., Kolovou, G.D., Peppes, V., Panagiotakos, D., Limberi, S., Zakopoulos, N., Metspalu, A. & Dedoussis, G.V.
Avaldatud: Clinical chemistry and laboratory medicine : CCLM / FESCC 47, 1471-3

 

2008 (6)

Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays.
Krjutskov, K., Andreson, R., Mägi, R., Nikopensius, T., Khrunin, A., Mihailov, E., Tammekivi, V., Sork, H., Remm, M. & Metspalu, A.
Avaldatud: Nucleic acids research 36, e75


Arrayed primer extension on in situ synthesized 5’-->3’ oligonucleotides in microchannels.
Pullat, J., Kusnezow, W., Jaakson, K., Beier, M., Hoheisel, J.D. & Metspalu, A.
Avaldatud: New biotechnology 25, 133-41


Arrayed primer extension reaction for genotyping on oligonucleotide microarray.
Pullat, J. & Metspalu, A.
Avaldatud: Methods in molecular biology (Clifton, N.J.) 444, 161-7


Androgen receptor gene haplotype is associated with male infertility.
Saare, M., Belousova, A., Punab, M., Peters, M., Haller, K., Ausmees, K., Poolamets, O., Karro, H., Metspalu, A. & Salumets, A.
Avaldatud: International journal of andrology 31, 395-402


Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population.
Tamm, R., Oselin, K., Kallassalu, K., Magi, R., Anier, K., Remm, M. & Metspalu, A.
Avaldatud: Clinical chemistry and laboratory medicine : CCLM / FESCC 46, 974-9


Aromatase gene (CYP19A1) allele variants are essential to controlled ovarian hyperstimulation outcome
Altmäe, S., Haller, K., Peters, M., Saare, M., Hovatta, O., Stavreus-Evers, A., Velthut, A., Karro, H., Metspalu, A. & Salumets, A.
Avaldatud: RBMOnline, Volume 17, No 3


 

2007 (2)

Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization.
Altmäe, S., Haller, K., Peters, M., Hovatta, O., Stavreus-Evers, A., Karro, H., Metspalu, A. & Salumets, A.
Avaldatud: Molecular human reproduction 13, 521-6


Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
Pullat, J., Fleischer, R., Becker, N., Beier, M., Metspalu, A. & Hoheisel, J.D.
Avaldatud: BMC genomics 8, 282


 

2005 (1)

L''Estonie parie sur les biotechnologies.
Eensaar, R. & Metspalu, A.
Avaldatud: Biofutur 257: 51-54


 

2004 (2)

[The Estonian Genome Project in the context of European genome research]
Metspalu, A., Köhler, F., Laschinski, G., Ganten, D. & Roots, I.
Avaldatud: Deutsche medizinische Wochenschrift (1946) 129 Suppl , S25-8


The Estonian Genome Project.
Metspalu, A.
Avaldatud: Drug Development Research 62, 97-101


 

2002 (2)

Estonian Genome Project--before the take-off and take-off.
Metspalu, A.
Avaldatud: Bioinformatics (Oxford, England) 18 Suppl 2, S152


Comment to: Pálsson, G. and Hardardóttir "For Whom the Cell Tolls"
Metspalu, A.
Avaldatud: Current Anthropology 43, 2